{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T07:17:52Z","timestamp":1781594272777,"version":"3.54.5"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,3,13]]},"abstract":"<jats:p>The health effects of integrated 24-hour movement guidelines (including moderate-to-vigorous physical activity, sedentary behavior, and sleep time) on osteoarthritis (OA) remain poorly understood. We examined the associations between adherence to 24-hour movement guidelines and OA prevalence and subsequent mortality. We analyzed data from 34,051 adults participating in National Health and Nutrition Examination Surveys (1999\u20132018). Osteoarthritis prevalence was evaluated using multivariable logistic regression. For survival analyses, 3594 participants with OA were linked to the National Death Index through 2019. Cox proportional hazards models were used to estimate adjusted hazard ratio (AHR) for all-cause and cardiovascular disease mortality. Meeting all 3 movement guidelines was associated with a lower prevalence of OA (adjusted odds ratio\u2005=\u20050.80, 95% confidence interval [95% CI]: 0.64\u20131.00) compared with meeting none. Among individuals with OA, greater adherence to movement guidelines was linked to a stepwise reduction in mortality risk. Participants meeting all 3 guidelines demonstrated the lowest risks of all-cause mortality (AHR\u2005=\u20050.34, 95% CI: 0.23\u20130.49) and cardiovascular disease mortality (AHR\u2005=\u20050.29, 95% CI: 0.13\u20130.61). Even partial adherence (meeting 1 or 2 guidelines) was associated with significant survival benefits relative to meeting none. Adherence to 24-hour movement guidelines is associated with lower OA prevalence and markedly reduced mortality risk among affected individuals.<\/jats:p>","DOI":"10.1097\/md.0000000000048060","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T20:00:21Z","timestamp":1773432021000},"page":"e48060","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Association between adherence to the 24-hour movement guidelines and the prevalence and mortality of osteoarthritis: A population-based study"],"prefix":"10.1097","volume":"105","author":[{"given":"Zhihui","family":"Quan","sequence":"first","affiliation":[{"name":"Bishan Hospital of Chongqing Medical University (Bishan Hospital of Chongqing), Bishan District, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1402-7596","authenticated-orcid":false,"given":"Dongli","family":"Huang","sequence":"additional","affiliation":[{"name":"Bishan Hospital of Chongqing Medical University (Bishan Hospital of Chongqing), Bishan District, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20260506","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1097\/BOR.0000000000000923","article-title":"Inflammation in osteoarthritis: the latest progress and ongoing challenges.","volume":"35","author":"Knights","year":"2023","journal-title":"Curr Opin Rheumatol"},{"key":"R2-20260506","doi-asserted-by":"crossref","first-page":"e508","DOI":"10.1016\/S2665-9913(23)00163-7","article-title":"GBD 2021 Osteoarthritis Collaborators. Global, regional, and national burden of osteoarthritis, 1990\u20132020 and projections to 2050: a systematic analysis for the Global Burden of Disease Study 2021.","volume":"5","year":"2023","journal-title":"Lancet Rheumatol"},{"key":"R3-20260506","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41413-023-00301-9","article-title":"Risk of metabolic abnormalities in osteoarthritis: a new perspective to understand its pathological mechanisms.","volume":"11","author":"Wei","year":"2023","journal-title":"Bone Res"},{"key":"R4-20260506","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1007\/s13679-023-00520-5","article-title":"Obesity, metabolic syndrome, and osteoarthritis \u2013 an updated review.","volume":"12","author":"Sampath","year":"2023","journal-title":"Curr Obes Rep"},{"key":"R5-20260506","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jsams.2022.11.003","article-title":"Exercise & Sports Science Australia (ESSA) updated Position Statement on exercise and physical activity for people with hip\/knee osteoarthritis.","volume":"26","author":"Hinman","year":"2023","journal-title":"J Sci Med Sport"},{"key":"R6-20260506","doi-asserted-by":"crossref","first-page":"04173","DOI":"10.7189\/jogh.15.04173","article-title":"Association between physical activity and knee osteoarthritis: a comprehensive systematic review and meta-analysis.","volume":"15","author":"Cui","year":"2025","journal-title":"J Glob Health"},{"key":"R7-20260506","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1080\/08870446.2022.2126473","article-title":"Physical activity, sedentary behaviour and well-being: experiences of people with knee and hip osteoarthritis.","volume":"39","author":"Kanavaki","year":"2024","journal-title":"Psychol Health"},{"key":"R8-20260506","doi-asserted-by":"crossref","first-page":"5673","DOI":"10.1093\/rheumatology\/keaf327","article-title":"Associations of healthy lifestyle and genetic susceptibility with risks of osteoarthritis: a prospective cohort study.","volume":"64","author":"Chen","year":"2025","journal-title":"Rheumatology (Oxford)"},{"key":"R9-20260506","doi-asserted-by":"crossref","first-page":"224","DOI":"10.3899\/jrheum.2023-0819","article-title":"The critical role of physical activity and weight management in knee and hip osteoarthritis: a narrative review.","volume":"51","author":"Huffman","year":"2024","journal-title":"J Rheumatol"},{"key":"R10-20260506","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/j.joca.2023.06.004","article-title":"Metabolic syndrome and osteoarthritis: implications for the management of an increasingly common phenotype.","volume":"31","author":"Peiris","year":"2023","journal-title":"Osteoarthritis Cartilage"},{"key":"R11-20260506","doi-asserted-by":"crossref","first-page":"6879","DOI":"10.1038\/s41598-025-91398-x","article-title":"Association between meeting the 24-hour movement guidelines and cardiometabolic syndrome in Korean adults.","volume":"15","author":"Choi","year":"2025","journal-title":"Sci Rep"},{"key":"R12-20260506","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12966-025-01722-x","article-title":"Is meeting 24-hour movement guidelines associated with a lower risk of frailty among adults?","volume":"22","author":"Liu","year":"2025","journal-title":"Int J Behav Nutr Phys Act"},{"key":"R13-20260506","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1139\/apnm-2021-0010","article-title":"Meeting Canadian 24-hour movement guideline recommendations and risk of all-cause mortality.","volume":"46","author":"Clarke","year":"2021","journal-title":"Appl Physiol Nutr Metab"},{"key":"R14-20260506","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13034-023-00588-w","article-title":"Associations of meeting 24-h movement behavior guidelines with cognitive difficulty and social relationships in children and adolescents with attention deficit\/hyperactive disorder.","volume":"17","author":"Taylor","year":"2023","journal-title":"Child Adolesc Psychiatry Ment Health"},{"key":"R15-20260506","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jad.2024.05.086","article-title":"Associations of meeting 24-hour movement behavior guidelines with social and emotional function in youth with ASD\/ADHD.","volume":"359","author":"Zhao","year":"2024","journal-title":"J Affect Disord"},{"key":"R16-20260506","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jad.2024.08.209","article-title":"Recent trends and disparities in 24-hour movement behaviors among US youth with mental, behavioral and neurodevelopmental conditions.","volume":"367","author":"Hou","year":"2024","journal-title":"J Affect Disord"},{"key":"R17-20260506","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.3390\/cells12162088","article-title":"Crosstalk between bone and muscles during physical activity.","volume":"12","author":"Dalle Carbonare","year":"2023","journal-title":"Cells"},{"key":"R18-20260506","doi-asserted-by":"crossref","first-page":"254","DOI":"10.4235\/agmr.24.0141","article-title":"Impact of physical activity level on whole-body and muscle-cell function in older adults.","volume":"29","author":"Yeo","year":"2025","journal-title":"Ann Geriatr Med Res"},{"key":"R19-20260506","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1001\/jamainternmed.2021.0991","article-title":"Effects of a self-directed web-based strengthening exercise and physical activity program supported by automated text messages for people with knee osteoarthritis: a randomized clinical trial.","volume":"181","author":"Nelligan","year":"2021","journal-title":"JAMA Intern Med"},{"key":"R20-20260506","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.3390\/nu12113299","article-title":"Impact of physical activity and weight loss on fat mass, glucose metabolism, and inflammation in older African Americans with osteoarthritis.","volume":"12","author":"McLeod","year":"2020","journal-title":"Nutrients"},{"key":"R21-20260506","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1186\/s12889-023-16867-2","article-title":"Sedentary behaviour and disease risk.","volume":"23","author":"Henson","year":"2023","journal-title":"BMC Public Health"},{"key":"R22-20260506","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1186\/1471-2458-14-333","article-title":"Sedentary behavior and health outcomes among older adults: a systematic review.","volume":"14","author":"de Rezende","year":"2014","journal-title":"BMC Public Health"},{"key":"R23-20260506","doi-asserted-by":"crossref","first-page":"156320","DOI":"10.1016\/j.metabol.2025.156320","article-title":"Sedentary behaviour and cardiometabolic health: integrating the potential underlying molecular health aspects.","volume":"170","author":"Franssen","year":"2025","journal-title":"Metabolism"},{"key":"R24-20260506","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1016\/j.joca.2018.07.002","article-title":"Reallocating time spent in sleep, sedentary behavior and physical activity and its association with pain: a pilot sleep study from the osteoarthritis initiative.","volume":"26","author":"Song","year":"2018","journal-title":"Osteoarthritis Cartilage"},{"key":"R25-20260506","doi-asserted-by":"crossref","first-page":"1624852","DOI":"10.3389\/fnut.2025.1624852","article-title":"The inflammatory potential of diet in adults with knee osteoarthritis: sex-specific associations with quality of life, sleep, fatigue and mental health.","volume":"12","author":"Law","year":"2025","journal-title":"Front Nutr"},{"key":"R26-20260506","doi-asserted-by":"crossref","first-page":"a029785","DOI":"10.1101\/cshperspect.a029785","article-title":"Effects of exercise and aging on skeletal muscle.","volume":"8","author":"Distefano","year":"2018","journal-title":"Cold Spring Harb Perspect Med"},{"key":"R27-20260506","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.cger.2011.03.009","article-title":"Physical activity and sarcopenia.","volume":"27","author":"Pillard","year":"2011","journal-title":"Clin Geriatr Med"},{"key":"R28-20260506","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12986-025-00907-2","article-title":"Anti-inflammatory diets might mitigate the association between sedentary behaviors and the risk of all-cause deaths.","volume":"22","author":"Wang","year":"2025","journal-title":"Nutr Metab (Lond)"},{"key":"R29-20260506","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1249\/JES.0000000000000106","article-title":"Sedentary behavior and cardiovascular disease risk: mediating mechanisms.","volume":"45","author":"Carter","year":"2017","journal-title":"Exerc Sport Sci Rev"},{"key":"R30-20260506","doi-asserted-by":"crossref","first-page":"101695","DOI":"10.1016\/j.smrv.2022.101695","article-title":"The differential effects of sleep deprivation on pain perception in individuals with or without chronic pain: a systematic review and meta-analysis.","volume":"66","author":"Chang","year":"2022","journal-title":"Sleep Med Rev"},{"key":"R31-20260506","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.sleep.2023.06.010","article-title":"Sleep deprivation increases pain sensitivity following acute muscle soreness.","volume":"109","author":"Palsson","year":"2023","journal-title":"Sleep Med"},{"key":"R32-20260506","doi-asserted-by":"crossref","first-page":"127292","DOI":"10.1016\/j.micres.2022.127292","article-title":"Acute sleep deprivation exacerbates systemic inflammation and psychiatry disorders through gut microbiota dysbiosis and disruption of circadian rhythms.","volume":"268","author":"Yang","year":"2023","journal-title":"Microbiol Res"}],"container-title":["Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/MD.0000000000048060","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T12:05:22Z","timestamp":1778069122000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/MD.0000000000048060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,13]]},"references-count":32,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.1097\/md.0000000000048060","relation":{},"ISSN":["0025-7974","1536-5964"],"issn-type":[{"value":"0025-7974","type":"print"},{"value":"1536-5964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,13]]},"assertion":[{"value":"2026-01-13","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-25","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}