{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T17:15:35Z","timestamp":1793898935415,"version":"4.8.0"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"32","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Research on the Establishment of Pan-Xiang Northwest Chest Pain Medical Center in Changde City","award":["CSP25JC125"],"award-info":[{"award-number":["CSP25JC125"]}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,8,7]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Insulin resistance is closely associated with various cardiovascular and metabolic diseases. The estimated glucose disposal rate (eGDR), as a convenient assessment indicator of insulin resistance, has been increasingly utilized in recent years for cardiovascular risk prediction. However, studies on the relationship between eGDR and chest pain risk remain relatively scarce. Based on the 2 major databases of National Health and Nutrition Examination Survey (NHANES) and China Health and Retirement Longitudinal Study (CHARLS), this study systematically analyzed the association between eGDR levels and the risk of chest pain and compared the similarities and differences in the results between the 2 populations. We utilized databases from 2 prospective cohorts, NHANES and CHARLS. The eGDR calculation formula was: eGDR = 21.158 \u2212 (0.09\u2005\u00d7\u2005WC) \u2212 (3.407\u2005\u00d7\u2005HTN) \u2212 (0.551\u2005\u00d7\u2005HbA1c). Here, WC represents waist circumference (cm), HTN indicates a history of hypertension (yes\u2005=\u20051, no\u2005=\u20050), and HbA1c denotes glycated hemoglobin (%). Participants were stratified according to eGDR levels into quartiles. A multivariate logistic regression model was employed to assess the association between eGDR and chest pain, with dose-response curves analyzed using restricted cubic spline analysis. In the fully adjusted model, the highest quartile of eGDR in CHARLS showed a trend of reduced risk for chest pain compared to the lowest quartile (odds ratio = 0.86, 95% confidence interval: 0.73\u20131.01,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .066), whereas a significant negative correlation was observed in NHANES (odds ratio = 0.54, 95% confidence interval: 0.45\u20130.65,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2005&lt;\u2005.001). Elevated eGDR (reduced insulin resistance) was significantly associated with a decreased risk of chest pain, suggesting that insulin resistance may be an important potential risk factor for chest pain. This association was consistent in both China and the United States, though the magnitude of the effect varied. This study supports the use of eGDR as a potential biomarker for identifying chest pain risk.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/md.0000000000050007","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T18:00:38Z","timestamp":1786125638000},"page":"e50007","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Association between eGDR and the risk of chest pain: A comparative analysis based on NHANES and CHARLS databases"],"prefix":"10.1097","volume":"105","author":[{"given":"Mengmeng","family":"Wang","sequence":"first","affiliation":[{"name":"The Affiliated Changde Hospital, Hengyang Medical School, University of South China, Changde, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangqing","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Changde Hospital, Xiangya School of Medicine, Central South University, Changde, Hunan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Ping","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Changde Hospital, Xiangya School of Medicine, Central South University, Changde, Hunan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Changde Hospital, Xiangya School of Medicine, Central South University, Changde, Hunan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congyu","family":"Chen","sequence":"additional","affiliation":[{"name":"The Affiliated Changde Hospital, Hengyang Medical School, University of South China, Changde, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20260807","doi-asserted-by":"crossref","first-page":"437","DOI":"10.31128\/AJGP-04-23-6810","article-title":"Chest pain.","volume":"53","author":"Rahman","year":"2024","journal-title":"Aust J Gen Pract"},{"key":"R2-20260807","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1161\/CIRCULATIONAHA.122.059678","article-title":"High-sensitivity cardiac troponin and the 2021 AHA\/ACC\/ASE\/CHEST\/SAEM\/SCCT\/SCMR guidelines for the evaluation and diagnosis of acute chest pain.","volume":"146","author":"Sandoval","year":"2022","journal-title":"Circulation"},{"key":"R3-20260807","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12933-025-02595-x","article-title":"Association between insulin resistance indices and outcomes in patients with heart failure with preserved ejection fraction.","volume":"24","author":"Ni","year":"2025","journal-title":"Cardiovasc Diabetol"},{"key":"R4-20260807","doi-asserted-by":"crossref","first-page":"3000605231164548","DOI":"10.1177\/03000605231164548","article-title":"Insulin resistance and cardiovascular disease.","volume":"51","author":"Kosmas","year":"2023","journal-title":"J Int Med Res"},{"key":"R5-20260807","doi-asserted-by":"crossref","first-page":"14791641231221202","DOI":"10.1177\/14791641231221202","article-title":"Progression of insulin resistance in individuals with type 1 diabetes: a retrospective longitudinal study on individuals from Thailand.","volume":"20","author":"Jirawatwarakul","year":"2023","journal-title":"Diab Vasc Dis Res"},{"key":"R6-20260807","doi-asserted-by":"crossref","first-page":"e113","DOI":"10.1016\/j.annemergmed.2022.12.008","article-title":"Man with chest pain.","volume":"81","author":"Lee","year":"2023","journal-title":"Ann Emerg Med"},{"key":"R7-20260807","first-page":"602","article-title":"Risk factors for in-hospital death in patients with acute myocardial infarction complicated by cardiogenic shock undergoing emergency percutaneous coronary intervention.","volume":"20","author":"Zhou","year":"2022","journal-title":"China J Cardiovasc Res"},{"key":"R8-20260807","first-page":"V106","article-title":"Clinical significance and risks of the use and failure of an intraaortic balloon pump (IABP) a statement of the Scientific Working Group for cardiac anesthesia of the german society for anesthesiology and intensive care medicine e.V. 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From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus.","volume":"58","author":"Defronzo","year":"2009","journal-title":"Diabetes"},{"key":"R12-20260807","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1186\/s12933-024-02396-8","article-title":"The additive effect of the triglyceride-glucose index and estimated glucose disposal rate on long-term mortality among individuals with and without diabetes: a population-based study.","volume":"23","author":"He","year":"2024","journal-title":"Cardiovasc Diabetol"},{"key":"R13-20260807","doi-asserted-by":"crossref","first-page":"e70100","DOI":"10.1002\/dmrr.70100","article-title":"Exploring insulin resistance in adults with type 1 diabetes: the role of the estimated glucose disposal rate and the triglyceride glucose index.","volume":"41","author":"Angelino","year":"2025","journal-title":"Diabetes Metab Res 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History"}},{"value":"2026-07-14","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}