{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T19:29:06Z","timestamp":1793647746344,"version":"4.5.1"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"42","license":[{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,10,16]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>To evaluate the objective response rate (ORR) and disease control rate of 3 Chinese herbal medicines (Compound Banmao Capsule, Huaier Granule, and Jinlong Capsule) combined with transarterial chemoembolization (TACE) for primary liver cancer using Bayesian network meta-analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We systematically searched randomized controlled trials (RCTs) across the Cochrane Library, Embase, PubMed, Web of Science, VIP Database for Chinese Technical Periodicals, China National Knowledge Infrastructure, and Wanfang databases from their inception to January 10, 2025. Two researchers independently screened the literature, extracted data, and assessed study quality using predefined inclusion and exclusion criteria. A Bayesian network meta-analysis was performed using RStudio to synthesize and hierarchically rank interventions by effect size in the included RCTs. This review was registered with PROSPERO (CRD420251019361).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Thirty-one RCTs involving 2604 patients with primary liver cancer were included. The network meta-analysis showed that, compared with TACE alone: Compound Banmao Capsule ranked highest for ORR (OR\u2005=\u20051.50, 95% CI: 1.08, 2.08), followed by Huaier Granule (OR\u2005=\u20051.47, 95% CI: 1.05, 2.05) and Jinlong Capsule (OR\u2005=\u20051.30, 95% CI: 1.02, 1.65). For disease control rate, the ranking was Compound Banmao Capsule (OR\u2005=\u20051.21, 95% CI: 0.76, 1.93), Jinlong Capsule (OR\u2005=\u20051.17, 95% CI: 0.85, 1.59), and Huaier Granule (OR\u2005=\u20051.12, 95% CI: 0.66, 1.91).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>For ORR, the combination of the 3 Chinese herbal medicines with TACE showed superior efficacy to TACE monotherapy, with Compound Banmao Capsule demonstrating the greatest therapeutic potential among the interventions evaluated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/md.0000000000051136","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:00:38Z","timestamp":1792173638000},"page":"e51136","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Three traditional Chinese patent medicines combined with transarterial chemoembolization for primary liver cancer"],"prefix":"10.1097","volume":"105","author":[{"given":"Wei","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Medicine, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Heilongjiang Academy of Chinese Medicine Sciences, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenguang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Heilongjiang Academy of Chinese Medicine Sciences, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"An","sequence":"additional","affiliation":[{"name":"Department of Medicine, Heilongjiang Academy of Chinese Medicine Sciences, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinzhong","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Medicine, Heilongjiang Academy of Chinese Medicine Sciences, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwei","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Heilongjiang Academy of Chinese Medicine Sciences, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengying","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Heilongjiang Academy of Chinese Medicine Sciences, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfeng","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Heilongjiang Academy of Chinese Medicine Sciences, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimei","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Medicine, Heilongjiang Academy of Chinese Medicine Sciences, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Second Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20261102","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.jhep.2024.10.031","article-title":"Liver cancer in 2021: global Burden of Disease study.","volume":"82","author":"Tan","year":"2025","journal-title":"J Hepatol"},{"key":"R2-20261102","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/cac2.12627","article-title":"Cancer situation in China: an analysis based on the global epidemiological data released in 2024.","volume":"45","author":"Diao","year":"2025","journal-title":"Cancer Commun (Lond)"},{"key":"R3-20261102","doi-asserted-by":"crossref","first-page":"5300523","DOI":"10.1155\/2022\/5300523","article-title":"On the core prescriptions and their mechanisms of traditional Chinese medicine in hepatitis B, liver cirrhosis, and liver cancer treatment.","volume":"2022","author":"Wang","year":"2022","journal-title":"J Oncol"},{"key":"R4-20261102","doi-asserted-by":"crossref","first-page":"F8","DOI":"10.1136\/archdischild-2018-315224","article-title":"Network meta-analysis explained.","volume":"104","author":"Dias","year":"2019","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"R5-20261102","first-page":"24","article-title":"Effect of Compound Banmao Capsule as an adjunct to interventional chemotherapy on enhancing efficacy and reducing toxicity and Th17\/Treg balance in patients with primary liver cancer.","volume":"36","author":"Yang","year":"2023","journal-title":"Traditional Chin Med Res"},{"key":"R6-20261102","first-page":"609","article-title":"Effect of Compound Banmao Capsule combined with TACE on serum tumor marker levels and KPS scores in patients with primary liver cancer.","volume":"35","author":"Dai","year":"2022","journal-title":"J Med Theory Pract"},{"key":"R7-20261102","first-page":"81","article-title":"Efficacy and safety of Compound Cantharides Capsules combined with transhepatic arterial chemoembolization in the treatment of hepatocellular carcinoma.","volume":"30","author":"Tang","year":"2021","journal-title":"China Pharm"},{"key":"R8-20261102","first-page":"365","article-title":"Effect of Compound Banmao Capsule on immune function and clinical efficacy in patients with primary liver cancer.","volume":"15","author":"Hong","year":"2020","journal-title":"World J Integr Tradit Western Med"},{"key":"R9-20261102","first-page":"2785","article-title":"Effect and mechanism of Compound Banmao Capsule on cellular immune function after interventional therapy for primary liver cancer.","volume":"37","author":"Zhao","year":"2019","journal-title":"Chin Arch Tradit Chin Med"},{"key":"R10-20261102","first-page":"77","article-title":"Effect of Compound Banmao Capsule on cellular immune function in patients with primary liver cancer after interventional therapy.","volume":"39","author":"Zhao","year":"2018","journal-title":"Shaanxi J Tradit Chin Med"},{"key":"R11-20261102","first-page":"260","article-title":"Analysis of the therapeutic effect of Compound Banmao Capsule combined with TACE in the treatment of patients with intermediate and advanced primary liver cancer.","volume":"13","author":"Wang","year":"2015","journal-title":"Contemp Med Symposium"},{"key":"R12-20261102","first-page":"1030","article-title":"Observation on the efficacy of Compound Banmao Capsule combined with hepatic arterial embolization chemotherapy in the treatment of primary liver 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Jinlong Capsule in the treatment of intermediate and advanced liver cancer with blood stasis and stagnation syndrome and its influence on immune function.","volume":"51","author":"Wang","year":"2022","journal-title":"Shanxi Med J"},{"key":"R24-20261102","first-page":"506","article-title":"Efficacy of Jinlong Capsule combined with interventional therapy for primary liver cancer and its effects on T lymphocyte subsets and tumor immune factors.","volume":"23","author":"Zheng","year":"2018","journal-title":"Modern Digest Interv"},{"key":"R25-20261102","first-page":"157","article-title":"Clinical analysis of Jinlong Capsule in reducing adverse reactions after TACE in patients with liver cancer.","volume":"40","author":"Huang","year":"2013","journal-title":"Chin J Clin Oncol"},{"key":"R26-20261102","first-page":"110","article-title":"Clinical evaluation of Jinlong Capsule combined with TACE in the treatment of primary liver 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model.","volume":"11","author":"Kim","year":"2021","journal-title":"Theranostics"},{"key":"R37-20261102","doi-asserted-by":"crossref","first-page":"6653460","DOI":"10.1155\/2021\/6653460","article-title":"Effective material basis and mechanism analysis of compound banmao capsule against tumors using integrative network pharmacology and molecular docking.","volume":"2021","author":"He","year":"2021","journal-title":"Evid Based Complement Alternat Med"},{"key":"R38-20261102","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1136\/gutjnl-2018-315983","article-title":"Effect of Huaier granule on recurrence after curative resection of HCC: a multicentre, randomised clinical trial.","volume":"67","author":"Chen","year":"2018","journal-title":"Gut"},{"key":"R39-20261102","doi-asserted-by":"crossref","first-page":"BSR20194019","DOI":"10.1042\/BSR20194019","article-title":"Efficacy and safety of Chinese patent medicine (Jinlong capsule) in the treatment of advanced hepatocellular carcinoma: a meta-analysis.","volume":"40","author":"Xu","year":"2020","journal-title":"Biosci Rep"}],"container-title":["Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/MD.0000000000051136","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T19:01:32Z","timestamp":1793646092000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.1097\/MD.0000000000051136"}},"subtitle":["A systematic review and Bayesian network meta-analysis"],"short-title":[],"issued":{"date-parts":[[2026,10,16]]},"references-count":39,"journal-issue":{"issue":"42","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.1097\/md.0000000000051136","relation":{},"ISSN":["0025-7974","1536-5964"],"issn-type":[{"value":"0025-7974","type":"print"},{"value":"1536-5964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,16]]},"assertion":[{"value":"2025-09-17","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-29","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}