{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T19:29:04Z","timestamp":1793647744618,"version":"4.5.1"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"42","license":[{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,10,16]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Natural orifice specimen extraction surgery (NOSES) has emerged as an advanced minimally invasive technique that eliminates abdominal wall incisions for specimen retrieval; nevertheless, comparative data on its efficacy relative to conventional minilaparotomy-assisted extraction in colorectal cancer (CRC) remain limited. This retrospective analysis was conducted on 126 patients who underwent laparoscopic CRC resection at our institution, allocated to either the NOSES group (transanal specimen extraction, n\u2005=\u200549) or the conventional group (minilaparotomy-assisted extraction, n\u2005=\u200577), comparing perioperative parameters, postoperative recovery indicators, complication rates, and pathological outcomes. The NOSES group demonstrated significantly shorter time to first flatus (2.3\u2005\u00b1\u20050.9 vs 2.9\u2005\u00b1\u20051.1 days,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2005=\u2005.002), time to first liquid diet (3.1\u2005\u00b1\u20051.0 vs 3.8\u2005\u00b1\u20051.3 days,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2005=\u2005.001), and postoperative hospital stay (8.4\u2005\u00b1\u20053.2 vs 10.1\u2005\u00b1\u20054.1 days,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2005=\u2005.014). Visual analog scale pain scores on postoperative day 1 were significantly lower in the NOSES group (3.2\u2005\u00b1\u20051.1 vs 4.5\u2005\u00b1\u20051.3,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2005&lt;\u2005.001), with reduced additional analgesic requirements (22.4% vs 44.2%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2005=\u2005.014). Overall complication rates were significantly lower in the NOSES group (12.2% vs 24.7%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2005=\u2005.043), with wound infections occurring exclusively in the conventional group (0% vs 6.5%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2005=\u2005.045). No significant differences were observed in operative time, estimated blood loss, anastomotic leakage, lymph node yield, or R0 resection rate (all\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2005&gt;\u2005.05). In conclusion, NOSES appears to be a safe and feasible alternative to conventional minilaparotomy-assisted specimen extraction in highly selected patients with CRC, offering advantages in postoperative pain control, gastrointestinal function recovery, and wound-related complication reduction without compromising oncological integrity.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/md.0000000000051179","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:00:49Z","timestamp":1792173649000},"page":"e51179","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Comparative outcomes of natural orifice specimen extraction surgery versus conventional minilaparotomy-assisted specimen extraction in colorectal cancer"],"prefix":"10.1097","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9062-8426","authenticated-orcid":false,"given":"Yongjian","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Colorectal Surgery, The First People\u2019s Hospital of Lin\u2019an District, Hangzhou, Zhejiang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8791-8055","authenticated-orcid":false,"given":"Runfeng","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, The First People\u2019s Hospital of Lin\u2019an District, Hangzhou, Zhejiang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4999-3501","authenticated-orcid":false,"given":"Wenli","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, The First People\u2019s Hospital of Lin\u2019an District, Hangzhou, Zhejiang, 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