{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:40:27Z","timestamp":1789191627234,"version":"build-2803163510"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1097\/med.0000000000000060","type":"journal-article","created":{"date-parts":[[2014,4,16]],"date-time":"2014-04-16T15:59:57Z","timestamp":1397663997000},"page":"154-158","source":"Crossref","is-referenced-by-count":6,"title":["Novel genes in primary aldosteronism"],"prefix":"10.1097","volume":"21","author":[{"given":"Evelyn","family":"Fischer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Beuschlein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-3-20211004","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1210\/jc.2003-031337","article-title":"Increased diagnosis of primary aldosteronism, including surgically correctable forms, in centers from five continents.","volume":"89","author":"Mulatero","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"R2-3-20211004","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1097\/00004872-200411000-00026","article-title":"Low-renin status in therapy-resistant hypertension: a clue to efficient treatment.","volume":"22","author":"Eide","year":"2004","journal-title":"J Hypertens"},{"key":"R3-3-20211004","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1530\/EJE-11-1013","article-title":"Screening for primary aldosteronism in hypertensive subjects: results from two German epidemiological studies.","volume":"167","author":"Hannemann","year":"2012","journal-title":"Eur J Endocrinol"},{"key":"R4-3-20211004","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1161\/HYPERTENSIONAHA.112.197111","article-title":"Observational study mortality in treated primary aldosteronism: the German Conns registry.","volume":"60","author":"Reincke","year":"2012","journal-title":"Hypertension"},{"key":"R5-3-20211004","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1001\/archinternmed.2007.33","article-title":"Cardiovascular outcomes in patients with primary aldosteronism after treatment.","volume":"168","author":"Catena","year":"2008","journal-title":"Arch Intern Med"},{"key":"R6-3-20211004","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/j.jacc.2005.01.015","article-title":"Evidence for an increased rate of cardiovascular events in patients with primary aldosteronism.","volume":"45","author":"Milliez","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"R7-3-20211004","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1055\/s-0029-1246189","article-title":"Is primary aldosteronism associated with diabetes mellitus Results of the German Conns registry.","volume":"42","author":"Reincke","year":"2010","journal-title":"Horm Metab Res"},{"key":"R8-3-20211004","doi-asserted-by":"crossref","first-page":"3266","DOI":"10.1210\/jc.2008-0104","article-title":"Case detection, diagnosis, and treatment of patients with primary aldosteronism: an endocrine society clinical practice guideline.","volume":"93","author":"Funder","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"R9-3-20211004","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/355262a0","article-title":"A chimaeric 11beta-hydroxylasealdosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension.","volume":"355","author":"Lifton","year":"1992","journal-title":"Nature"},{"key":"R10-3-20211004","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1126\/science.1198785","article-title":"K channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension.","volume":"331","author":"Choi","year":"2011","journal-title":"Science"},{"key":"R11-3-20211004","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/ng.2550","article-title":"Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension.","volume":"45","author":"Beuschlein","year":"2013","journal-title":"Nat Genet"},{"key":"R12-3-20211004","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1073\/pnas.1121407109","article-title":"Hypertension with or without adrenal hyperplasia due to different inherited mutations in the potassium channel KCNJ5.","volume":"109","author":"Scholl","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R13-3-20211004","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1161\/HYPERTENSIONAHA.111.183996","article-title":"KCNJ5 mutations in European families with nonglucocorticoid remediable familial hyperaldosteronism.","volume":"59","author":"Mulatero","year":"2012","journal-title":"Hypertension"},{"key":"R14-3-20211004","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1161\/HYPERTENSIONAHA.111.186478","article-title":"Prevalence, clinical, and molecular correlates of KCNJ5 mutations in primary aldosteronism.","volume":"59","author":"Boulkroun","year":"2012","journal-title":"Hypertension"},{"key":"R15-3-20211004","doi-asserted-by":"crossref","first-page":"e41926","DOI":"10.1371\/journal.pone.0041926","article-title":"Comprehensive re-sequencing of adrenal aldosterone producing lesions reveal three somatic mutations near the KCNJ5 potassium channel selectivity filter.","volume":"7","author":"Akerstrom","year":"2012","journal-title":"PLoS One"},{"key":"R16-3-20211004","doi-asserted-by":"crossref","first-page":"E819","DOI":"10.1210\/jc.2011-2965","article-title":"Microarray, qPCR, and KCNJ5 sequencing of aldosterone-producing adenomas reveal differences in genotype and phenotype between zona glomerulosa- and zona fasciculata-like tumors.","volume":"97","author":"Azizan","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"R17-3-20211004","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1161\/HYPERTENSIONAHA.111.187682","article-title":"The genetics of primary aldosteronism: chapter two.","volume":"59","author":"Funder","year":"2012","journal-title":"Hypertension"},{"key":"R18-3-20211004","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/ng.2716","article-title":"Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension.","volume":"45","author":"Azizan","year":"2013","journal-title":"Nat Genet"},{"key":"R19-3-20211004","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1210\/jc.2011-2885","article-title":"Expression and mutations of KCNJ5 mRNA in Japanese patients with aldosterone-producing adenomas.","volume":"97","author":"Taguchi","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"R20-3-20211004","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1530\/ERC-12-0022","article-title":"KCNJ5 mutations in the National Institutes of Health cohort of patients with primary hyperaldosteronism: an infrequent genetic cause of Conns syndrome.","volume":"19","author":"Xekouki","year":"2012","journal-title":"Endocr Relat Cancer"},{"key":"R21-3-20211004","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1210\/en.2011-1733","article-title":"Potassium channel mutant KCNJ5 T158A expression in HAC-15 cells increases aldosterone synthesis.","volume":"153","author":"Oki","year":"2012","journal-title":"Endocrinology"},{"key":"R22-3-20211004","doi-asserted-by":"crossref","first-page":"R85","DOI":"10.1530\/EJE-13-0263","article-title":"Regulation of aldosterone secretion: from physiology to disease.","volume":"168","author":"Beuschlein","year":"2013","journal-title":"Eur J Endocrinol"},{"key":"R23-3-20211004","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1038\/ng.2695","article-title":"Somatic and germline CACNA1D calcium channel mutations in aldosterone-producing adenomas and primary aldosteronism.","volume":"45","author":"Scholl","year":"2013","journal-title":"Nat Genet"},{"key":"R24-3-20211004","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/nature06419","article-title":"Crystal structure of the sodium-potassium pump.","volume":"450","author":"Morth","year":"2007","journal-title":"Nature"},{"key":"R25-3-20211004","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.abb.2008.02.026","article-title":"The plasma membrane Ca2 ATPase of animal cells: structure, function and regulation.","volume":"476","author":"Di Leva","year":"2008","journal-title":"Arch Biochem Biophys"},{"key":"R26-3-20211004","doi-asserted-by":"crossref","first-page":"E2307","DOI":"10.1210\/jc.2012-2342","article-title":"Somatic mutations in the KCNJ5 gene raise the lateralization index: implications for the diagnosis of primary aldosteronism by adrenal vein sampling.","volume":"97","author":"Seccia","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"R27-3-20211004","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1530\/EJE-13-0551","article-title":"Lack of influence of somatic mutations on steroid gradients of adrenal vein sampling in aldosterone producing adenomas.","volume":"169","author":"Osswald","year":"2013","journal-title":"Eur J Endocrinol"},{"key":"R28-3-20211004","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.peptides.2004.05.011","article-title":"Ghrelin enhances the growth of cultured human adrenal zona glomerulosa cells by exerting MAPK-mediated proliferogenic and antiapoptotic effects.","volume":"25","author":"Mazzocchi","year":"2004","journal-title":"Peptides"},{"key":"R29-3-20211004","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s12022-009-9060-8","article-title":"Primary aldosteronism with aldosterone-producing adenoma consisting of pure zona glomerulosa-type cells in a pregnant woman.","volume":"20","author":"Shigematsu","year":"2009","journal-title":"Endocr Pathol"},{"key":"R30-3-20211004","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1152\/physrev.00030.2003","article-title":"Control of aldosterone secretion: a model for convergence in cellular signaling pathways.","volume":"84","author":"Spat","year":"2004","journal-title":"Physiol Rev"},{"key":"R31-3-20211004","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1136\/pgmj.75.882.235","article-title":"Calcium-channel blockade can mask the diagnosis of Conns syndrome.","volume":"75","author":"Brown","year":"1999","journal-title":"Postgrad Med J"}],"container-title":["Current Opinion in Endocrinology, Diabetes & Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/01266029-201406000-00003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T12:13:39Z","timestamp":1633522419000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01266029-201406000-00003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.1097\/med.0000000000000060","relation":{},"ISSN":["1752-296X"],"issn-type":[{"value":"1752-296X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,6]]}}}