{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T10:49:03Z","timestamp":1652698143796},"reference-count":50,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1097\/med.0b013e328013e79e","type":"journal-article","created":{"date-parts":[[2011,1,14]],"date-time":"2011-01-14T07:01:49Z","timestamp":1294988509000},"page":"68-73","source":"Crossref","is-referenced-by-count":5,"title":["Glucagon-like peptide 1: continued advances, new targets and expanding promise as a model therapeutic"],"prefix":"10.1097","volume":"14","author":[{"given":"Benedikt","family":"Aulinger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"D'Alessio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"issue":"11\u201312","key":"R1-14-20211004","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1055\/s-2004-826178","article-title":"GLP-1 receptor agonists and DPP-4 inhibitors in the treatment of type 2 diabetes","volume":"36","author":"Ahren","year":"2004","journal-title":"Horm Metab Res"},{"key":"R2-14-20211004","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1136\/gut.2004.059741","article-title":"Endogenous glucagon-like peptide 1 controls endocrine pancreatic secretion and antro-pyloro-duodenal motility in humans","volume":"55","author":"Schirra","year":"2006","journal-title":"Gut"},{"key":"R3-14-20211004","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1210\/edrv.20.6.0385","article-title":"The glucagon-like peptides","volume":"20","author":"Kieffer","year":"1999","journal-title":"Endocr Rev"},{"key":"R4-14-20211004","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.cmet.2006.01.004","article-title":"The biology of incretin hormones","volume":"3","author":"Drucker","year":"2006","journal-title":"Cell Metab"},{"key":"R5-14-20211004","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1365-2362.1992.tb01464.x","article-title":"Glucagon-like peptide-1 cells in the gastrointestinal tract and pancreas of rat, pig and man","volume":"22","author":"Eissele","year":"1992","journal-title":"Eur J Clin Invest"},{"key":"R6-14-20211004","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1172\/JCI118411","article-title":"Gastric emptying and release of incretin hormones after glucose ingestion in humans","volume":"97","author":"Schirra","year":"1996","journal-title":"J Clin Invest"},{"key":"R7-14-20211004","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1159\/000201231","article-title":"Glucagon-like peptide-1 and glucose-dependent insulin-releasing polypeptide plasma levels in response to nutrients","volume":"56","author":"Herrmann","year":"1995","journal-title":"Digestion"},{"issue":"11\u201312","key":"R8-14-20211004","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1055\/s-2004-826159","article-title":"Nutrient, neural and endocrine control of glucagon-like peptide secretion","volume":"36","author":"Dube","year":"2004","journal-title":"Horm Metab Res"},{"key":"R9-14-20211004","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1097\/01.sla.0000183349.16877.84","article-title":"Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters","volume":"243","author":"Le Roux","year":"2006","journal-title":"Ann Surg"},{"key":"R10-14-20211004","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1097\/01.sla.0000133117.12646.48","article-title":"The early effect of the Roux-en-Y gastric bypass on hormones involved in body weight regulation and glucose metabolism","volume":"240","author":"Rubino","year":"2004","journal-title":"Ann Surg"},{"key":"R11-14-20211004","first-page":"491","article-title":"Control of body weight by lower gut signals","volume":"5","author":"Koopmans","year":"1981","journal-title":"Int J Obes"},{"key":"R12-14-20211004","doi-asserted-by":"crossref","first-page":"E447","DOI":"10.1152\/ajpendo.00153.2004","article-title":"Weight loss through ileal transposition is accompanied by increased ileal hormone secretion and synthesis in rats","volume":"288","author":"Strader","year":"2005","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"11\u201312","key":"R13-14-20211004","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1055\/s-2004-826160","article-title":"Circulation and degradation of GIP and GLP-1","volume":"36","author":"Deacon","year":"2004","journal-title":"Horm Metab Res"},{"key":"R14-14-20211004","doi-asserted-by":"crossref","first-page":"E1118","DOI":"10.1152\/ajpendo.00576.2005","article-title":"The glucagon-like peptide-1 metabolite GLP-1-(9-36) amide reduces postprandial glycemia independently of gastric emptying and insulin secretion in humans","volume":"290","author":"Meier","year":"2006","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"R15-14-20211004","doi-asserted-by":"crossref","first-page":"E873","DOI":"10.1152\/ajpendo.00452.2001","article-title":"GLP-1-(9-36) amide reduces blood glucose in anesthetized pigs by a mechanism that does not involve insulin secretion","volume":"282","author":"Deacon","year":"2002","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"R16-14-20211004","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1210\/jc.2002-021479","article-title":"Effects of GLP-1-(7-36)NH2, GLP-1-(7-37), and GLP-1-(9-36)NH2 on intravenous glucose tolerance and glucose-induced insulin secretion in healthy humans","volume":"88","author":"Vahl","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"R17-14-20211004","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s00125-005-0098-y","article-title":"The metabolite generated by dipeptidyl-peptidase 4 metabolism of glucagon-like peptide-1 has no influence on plasma glucose levels in patients with type 2 diabetes","volume":"49","author":"Zander","year":"2006","journal-title":"Diabetologia"},{"key":"R18-14-20211004","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0306-4522(96)00434-4","article-title":"Distribution of glucagon-like peptide-1 and other preproglucagon-derived peptides in the rat hypothalamus and brainstem","volume":"77","author":"Larsen","year":"1997","journal-title":"Neuroscience"},{"key":"R19-14-20211004","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/379069a0","article-title":"A role for glucagon-like peptide-1 in the central regulation of feeding","volume":"379","author":"Turton","year":"1996","journal-title":"Nature"},{"issue":"4","key":"R20-14-20211004","doi-asserted-by":"crossref","first-page":"R848","DOI":"10.1152\/ajpregu.1996.271.4.R848","article-title":"Central administration of GLP-1-(7-36) amide inhibits food and water intake in rats","volume":"271","author":"Tang-Christensen","year":"1996","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"2","key":"R21-14-20211004","doi-asserted-by":"crossref","first-page":"R726","DOI":"10.1152\/ajpregu.1997.272.2.R726","article-title":"Central infusion of GLP-1, but not leptin, produces conditioned taste aversions in rats","volume":"272","author":"Thiele","year":"1997","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"5","key":"R22-14-20211004","doi-asserted-by":"crossref","first-page":"R1537","DOI":"10.1152\/ajpregu.1999.277.5.R1537","article-title":"A functional role for central glucagon-like peptide-1 receptors in lithium chloride-induced anorexia","volume":"277","author":"Rinaman","year":"1999","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"R23-14-20211004","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1523\/JNEUROSCI.20-04-01616.2000","article-title":"The role of CNS glucagon-like peptide-1 (7-36) amide receptors in mediating the visceral illness effects of lithium chloride","volume":"20","author":"Seeley","year":"2000","journal-title":"J Neurosci"},{"key":"R24-14-20211004","doi-asserted-by":"crossref","first-page":"10470","DOI":"10.1523\/JNEUROSCI.22-23-10470.2002","article-title":"The diverse roles of specific GLP-1 receptors in the control of food intake and the response to visceral illness","volume":"22","author":"Kinzig","year":"2002","journal-title":"J Neurosci"},{"key":"R25-14-20211004","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1210\/en.2004-0419","article-title":"The role of central glucagon-like peptide-1 in mediating the effects of visceral illness: differential effects in rats and mice","volume":"146","author":"Lachey","year":"2005","journal-title":"Endocrinology"},{"key":"R26-14-20211004","doi-asserted-by":"crossref","first-page":"R1449","DOI":"10.1152\/ajpregu.2000.279.4.R1449","article-title":"Portal GLP-1 administration in rats augments the insulin response to glucose via neuronal mechanisms","volume":"279","author":"Balkan","year":"2000","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"R27-14-20211004","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.2337\/diabetes.50.8.1720","article-title":"Glucose competence of the hepatoportal vein sensor requires the presence of an activated glucagon-like peptide-1 receptor","volume":"50","author":"Burcelin","year":"2001","journal-title":"Diabetes"},{"key":"R28-14-20211004","doi-asserted-by":"crossref","first-page":"E779","DOI":"10.1152\/ajpendo.00106.2005","article-title":"Exogenously imposed postprandial-like rises in systemic glucose and GLP-1 do not produce an incretin effect, suggesting an indirect mechanism of GLP-1 action","volume":"291","author":"Ionut","year":"2006","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"R29-14-20211004","doi-asserted-by":"crossref","first-page":"3554","DOI":"10.1172\/JCI25764","article-title":"Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage","volume":"115","author":"Knauf","year":"2005","journal-title":"J Clin Invest"},{"issue":"4","key":"R30-14-20211004","doi-asserted-by":"crossref","first-page":"L374","DOI":"10.1152\/ajplung.1993.265.4.L374","article-title":"GLP-1 stimulates secretion of macromolecules from airways and relaxes pulmonary artery","volume":"265","author":"Richter","year":"1993","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"R31-14-20211004","doi-asserted-by":"crossref","first-page":"2968","DOI":"10.1210\/endo.137.7.8770921","article-title":"Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor","volume":"137","author":"Bullock","year":"1996","journal-title":"Endocrinology"},{"issue":"3","key":"R32-14-20211004","first-page":"E459","article-title":"Changes in arterial blood pressure and heart rate induced by glucagon-like peptide-1-(7-36) amide in rats","volume":"266","author":"Barragan","year":"1994","journal-title":"Am J Physiol Endocrinol Physiol"},{"issue":"5","key":"R33-14-20211004","first-page":"E784","article-title":"Neural contribution to the effect of glucagon-like peptide-1-(7-36) amide on arterial blood pressure in rats","volume":"277","author":"Barragan","year":"1999","journal-title":"Am J Physiol Endocrinol Physiol"},{"key":"R34-14-20211004","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1172\/JCI0215595","article-title":"Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons","volume":"110","author":"Yamamoto","year":"2002","journal-title":"J Clin Invest"},{"key":"R35-14-20211004","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1210\/en.2003-0007","article-title":"Cardiac function in mice lacking the glucagon-like peptide-1 receptor","volume":"144","author":"Gros","year":"2003","journal-title":"Endocrinology"},{"key":"R36-14-20211004","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1161\/01.CIR.0000120505.91348.58","article-title":"Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion","volume":"109","author":"Nikolaidis","year":"2004","journal-title":"Circulation"},{"key":"R37-14-20211004","doi-asserted-by":"crossref","first-page":"E1209","DOI":"10.1152\/ajpendo.00237.2004","article-title":"Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease","volume":"287","author":"Nystrom","year":"2004","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"R38-14-20211004","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1161\/01.CIR.0000139339.85840.DD","article-title":"Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathy","volume":"110","author":"Nikolaidis","year":"2004","journal-title":"Circulation"},{"key":"R39-14-20211004","doi-asserted-by":"crossref","first-page":"H2401","DOI":"10.1152\/ajpheart.00347.2005","article-title":"Active metabolite of GLP-1 mediates myocardial glucose uptake and improves left ventricular performance in conscious dogs with dilated cardiomyopathy","volume":"289","author":"Nikolaidis","year":"2005","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"R40-14-20211004","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1124\/jpet.104.073890","article-title":"Glucagon-like peptide-1 limits myocardial stunning following brief coronary occlusion and reperfusion in conscious canines","volume":"312","author":"Nikolaidis","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"R41-14-20211004","doi-asserted-by":"crossref","first-page":"146","DOI":"10.2337\/diabetes.54.1.146","article-title":"Glucagon-like peptide 1 can directly protect the heart against ischemia\/reperfusion injury","volume":"54","author":"Bose","year":"2005","journal-title":"Diabetes"},{"key":"R42-14-20211004","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.2337\/diabetes.48.12.2270","article-title":"Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats","volume":"48","author":"Xu","year":"1999","journal-title":"Diabetes"},{"key":"R43-14-20211004","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1210\/endo.142.5.8128","article-title":"Glucagon-like peptide-1 causes pancreatic duodenal homeobox-1 protein translocation from the cytoplasm to the nucleus of pancreatic beta-cells by a cyclic adenosine monophosphate\/protein kinase A-dependent mechanism","volume":"142","author":"Wang","year":"2001","journal-title":"Endocrinology"},{"issue":"Suppl 3","key":"R44-14-20211004","doi-asserted-by":"crossref","first-page":"S443","DOI":"10.2337\/diabetes.51.2007.S443","article-title":"Glucagon-like peptide-1 receptor activation antagonizes voltage-dependent repolarizing K(+) currents in beta-cells: a possible glucose-dependent insulinotropic mechanism","volume":"51","author":"MacDonald","year":"2002","journal-title":"Diabetes"},{"key":"R45-14-20211004","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1007\/s00125-004-1327-5","article-title":"Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells","volume":"47","author":"Wang","year":"2004","journal-title":"Diabetologia"},{"key":"R46-14-20211004","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1007\/s00125-005-1787-2","article-title":"Glucagon-like peptide-1 protects beta cells from cytokine-induced apoptosis and necrosis: role of protein kinase B","volume":"48","author":"Li","year":"2005","journal-title":"Diabetologia"},{"key":"R47-14-20211004","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1074\/jbc.M508307200","article-title":"Exendin-4 uses Irs2 signaling to mediate pancreatic beta cell growth and function","volume":"281","author":"Park","year":"2006","journal-title":"J Biol Chem"},{"key":"R48-14-20211004","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.2337\/db05-0825","article-title":"Transcription factor Fox01 mediates glucagon-like peptide-1 effects on pancreatic beta-cell mass","volume":"55","author":"Buteau","year":"2006","journal-title":"Diabetes"},{"key":"R49-14-20211004","doi-asserted-by":"crossref","first-page":"13468","DOI":"10.1073\/pnas.0600655103","article-title":"Improving function and survival of pancreatic islets by endogenous production of glucagon-like peptide 1 (GLP-1)","volume":"103","author":"Wideman","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R50-14-20211004","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1210\/en.2004-1349","article-title":"Exenatide (exendin-4) improves insulin sensitivity and {beta}-cell mass in insulin-resistant obese fa\/fa Zucker rats independent of glycemia and body weight","volume":"146","author":"Gedulin","year":"2005","journal-title":"Endocrinology"}],"container-title":["Current Opinion in Endocrinology, Diabetes & Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/01266029-200702000-00014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T01:09:14Z","timestamp":1633482554000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01266029-200702000-00014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007]]}},"URL":"https:\/\/doi.org\/10.1097\/med.0b013e328013e79e","relation":{},"ISSN":["1752-296X"],"issn-type":[{"value":"1752-296X","type":"print"}],"subject":[],"published":{"date-parts":[[2007,2]]}}}