{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T23:01:19Z","timestamp":1772578879291,"version":"3.50.1"},"reference-count":61,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,6]]},"DOI":"10.1097\/med.0b013e32832b20a8","type":"journal-article","created":{"date-parts":[[2011,1,14]],"date-time":"2011-01-14T06:51:40Z","timestamp":1294987900000},"page":"232-239","source":"Crossref","is-referenced-by-count":19,"title":["Androgen therapy for delayed male puberty"],"prefix":"10.1097","volume":"16","author":[{"given":"Geoffrey R","family":"Ambler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-7-20211004","first-page":"136","article-title":"Short stature","author":"Cowell","year":"1995"},{"key":"R2-7-20211004","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1097\/MED.0b013e328320253c","article-title":"What controls the timing of puberty? An update on progress from genetic investigation","volume":"16","author":"Gajdos","year":"2009","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"R3-7-20211004","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1093\/humupd\/dmn058","article-title":"The role of kisspeptin in the control of gonadotrophin secretion","volume":"15","author":"Roseweir","year":"2009","journal-title":"Hum Reprod Update"},{"key":"R4-7-20211004","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1111\/j.1365-2826.2007.01598.x","article-title":"The genetic basis for the timing of human puberty","volume":"19","author":"Banerjee","year":"2007","journal-title":"J Neuroendocrinol"},{"key":"R5-7-20211004","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1210\/jc.2004-0649","article-title":"Determination of sequence variation and haplotype structure for the gonadotropin-releasing hormone (GnRH) and GnRH receptor genes: investigation of role in pubertal timing","volume":"90","author":"Sedlmeyer","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"R6-7-20211004","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1056\/NEJMoa066494","article-title":"Reversal of idiopathic hypogonadotropic hypogonadism","volume":"357","author":"Raivio","year":"2007","journal-title":"N Engl J Med"},{"key":"R7-7-20211004","first-page":"4388","article-title":"The genetic and clinical heterogeneity of gonadotropin-releasing hormone deficiency in the human","volume":"81","author":"Waldstreicher","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"R8-7-20211004","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1530\/eje.1.02184","article-title":"Phenotypic variation in constitutional delay of growth and puberty: relationship to specific leptin and leptin receptor gene polymorphisms","volume":"155","author":"Banerjee","year":"2006","journal-title":"Eur J Endocrinol"},{"key":"R9-7-20211004","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1530\/eje.0.1300065","article-title":"Treatment of growth delay in boys with isolated growth hormone deficiency","volume":"130","author":"Albanese","year":"1994","journal-title":"Eur J Endocrinol"},{"key":"R10-7-20211004","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/BF00439244","article-title":"Pubertal development in male hypopituitarism","volume":"145","author":"Martinez","year":"1986","journal-title":"Eur J Pediatr"},{"issue":"Suppl 3","key":"R11-7-20211004","first-page":"480","article-title":"GH1 gene deletions and IGHD type 1A","volume":"3","author":"Cogan","year":"2006","journal-title":"Pediatr Endocrinol Rev"},{"key":"R12-7-20211004","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1530\/EJE-07-0769","article-title":"Constitutional delay of growth and puberty is not commonly associated with mutations in the acid labile subunit gene","volume":"158","author":"Banerjee","year":"2008","journal-title":"Eur J Endocrinol"},{"key":"R13-7-20211004","first-page":"3278","article-title":"The role of luteinizing hormone-beta gene polymorphism in the onset and progression of puberty in healthy boys","volume":"81","author":"Raivio","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"R14-7-20211004","doi-asserted-by":"crossref","first-page":"5581","DOI":"10.1210\/jc.2002-020862","article-title":"Pedigree analysis of constitutional delay of growth and maturation: determination of familial aggregation and inheritance patterns","volume":"87","author":"Sedlmeyer","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"R15-7-20211004","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1210\/jc.2007-1786","article-title":"Patterns of inheritance of constitutional delay of growth and puberty in families of adolescent girls and boys referred to specialist pediatric care","volume":"93","author":"Wehkalampi","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"R16-7-20211004","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1210\/jcem.87.4.8395","article-title":"Delayed puberty: analysis of a large case series from an academic center","volume":"87","author":"Sedlmeyer","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"R17-7-20211004","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/j.1365-2605.2007.00833.x","article-title":"The KiSS-1\/GPR54 system: putative target for endocrine disruption of reproduction at hypothalamic-pituitary unit?","volume":"31","author":"Navarro","year":"2008","journal-title":"Int J Androl"},{"key":"R18-7-20211004","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.1742-7843.2007.00180.x","article-title":"Endocrine disruptors and abnormalities of pubertal development","volume":"102","author":"Schoeters","year":"2008","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"R19-7-20211004","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1289\/ehp.02110771","article-title":"Sexual maturation in relation to polychlorinated aromatic hydrocarbons: Sharpe and Skakkebaek's hypothesis revisited","volume":"110","author":"Den Hond","year":"2002","journal-title":"Environ Health Perspect"},{"key":"R20-7-20211004","first-page":"273","article-title":"Puberty and its disorders","author":"Lee","year":"2007"},{"key":"R21-7-20211004","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S0022-3476(95)70265-2","article-title":"Pubertal staging in boys","volume":"127","author":"Biro","year":"1995","journal-title":"J Pediatr"},{"key":"R22-7-20211004","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1053\/beem.2001.0186","article-title":"Delayed puberty","volume":"16","author":"Traggiai","year":"2002","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"R23-7-20211004","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1053\/ybeog.2003.0360","article-title":"Disorders of pubertal development","volume":"17","author":"Traggiai","year":"2003","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"R24-7-20211004","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1203\/00006450-200110000-00010","article-title":"Pubertal development in The Netherlands 1965\u20131997","volume":"50","author":"Mul","year":"2001","journal-title":"Pediatr Res"},{"key":"R25-7-20211004","first-page":"61","article-title":"Testicular volume during adolescence. Cross-sectional and longitudinal studies","volume":"29","author":"Zachmann","year":"1974","journal-title":"Helv Paediatr Acta"},{"key":"R26-7-20211004","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0022-3476(85)80501-1","article-title":"Clinical longitudinal standards for height and height velocity for North American children","volume":"107","author":"Tanner","year":"1985","journal-title":"J Pediatr"},{"key":"R27-7-20211004","first-page":"911","article-title":"National estimates of the timing of sexual maturation and racial differences among US children","volume":"110","author":"Sun","year":"2002","journal-title":"P"},{"key":"R28-7-20211004","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1136\/adc.45.239.13","article-title":"Variations in the pattern of pubertal changes in boys","volume":"45","author":"Marshall","year":"1970","journal-title":"Arch Dis Child"},{"key":"R29-7-20211004","first-page":"240","article-title":"Testicular size: assessment and clinical importance","volume":"7","author":"Prader","year":"1966","journal-title":"Triangle"},{"key":"R31-7-20211004","first-page":"1","article-title":"Worrisome growth","author":"Grimberg","year":"2007"},{"key":"R32-7-20211004","first-page":"26","article-title":"Early morning plasma testosterone is an accurate predictor of imminent pubertal development in prepubertal boys","volume":"76","author":"Wu","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"R33-7-20211004","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1530\/eje.0.1490023","article-title":"The human chorionic gonadotropin test is more powerful than the gonadotropin-releasing hormone agonist test to discriminate male isolated hypogonadotropic hypogonadism from constitutional delayed puberty","volume":"149","author":"Degros","year":"2003","journal-title":"Eur J Endocrinol"},{"key":"R34-7-20211004","first-page":"562","article-title":"A longitudinal study of the relationship of plasma somatomedin-C concentration to the pubertal growth spurt","volume":"141","author":"Cara","year":"1987","journal-title":"Am J Dis Child"},{"key":"R35-7-20211004","first-page":"107","article-title":"Diagnosis of growth hormone deficiency and growth hormone secretion tests","author":"Ranke","year":"2003"},{"key":"R36-7-20211004","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jpeds.2005.08.045","article-title":"Evaluation of the buserelin stimulation test in diagnosing gonadotropin deficiency in males with delayed puberty","volume":"148","author":"Wilson","year":"2006","journal-title":"J Pediatr"},{"key":"R38-7-20211004","first-page":"1798","article-title":"Ontogeny of pulsatile gonadotropin releasing hormone secretion from midchildhood, through puberty, to adulthood in the human male: a study using deconvolution analysis and an ultrasensitive immunofluorometric assay","volume":"81","author":"Wu","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"issue":"Suppl 1","key":"R39-7-20211004","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1530\/EJE-08-0314","article-title":"Inducing puberty","volume":"159","author":"Delemarre","year":"2008","journal-title":"Eur J Endocrinol"},{"key":"R40-7-20211004","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1515\/JPEM.2006.19.1.55","article-title":"A workshop on pubertal hormone replacement options in the United States","volume":"19","author":"Drobac","year":"2006","journal-title":"J Pediatr Endocrinol Metab"},{"key":"R41-7-20211004","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0031-3955(16)33820-2","article-title":"The effect of early versus late physical maturation on adolescent behavior","volume":"27","author":"Gross","year":"1980","journal-title":"Pediatr Clin North Am"},{"key":"R42-7-20211004","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S0022-3476(82)80775-0","article-title":"Educational correlates of early and late sexual maturation in adolescence","volume":"100","author":"Duke","year":"1982","journal-title":"J Pediatr"},{"key":"R43-7-20211004","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1136\/adc.65.10.1109","article-title":"Final height in boys with untreated constitutional delay in growth and puberty","volume":"65","author":"Crowne","year":"1990","journal-title":"Arch Dis Child"},{"key":"R44-7-20211004","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/BF01956736","article-title":"Does constitutional delayed puberty cause segmental disproportion and short stature?","volume":"152","author":"Albanese","year":"1993","journal-title":"Eur J Pediatr"},{"key":"R45-7-20211004","first-page":"99","article-title":"Progressive reduction of relative height in childhood predicts adult stature below target height in boys with constitutional delay of growth and puberty","volume":"68","author":"Wehkalampi","year":"2007","journal-title":"Horm Res"},{"key":"R46-7-20211004","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1159\/000137663","article-title":"Boys with a simple delayed puberty reach their target height","volume":"70","author":"Cools","year":"2008","journal-title":"Horm Res"},{"key":"R47-7-20211004","first-page":"1152","article-title":"A longitudinal evaluation of bone mineral density in adult men with histories of delayed puberty","volume":"81","author":"Finkelstein","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"R48-7-20211004","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.1210\/jc.2005-0086","article-title":"Bone mineral density and markers of bone turnover in boys with constitutional delay of growth and puberty","volume":"90","author":"Krupa","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"R49-7-20211004","doi-asserted-by":"crossref","first-page":"4280","DOI":"10.1210\/jcem.83.12.5348","article-title":"Normal volumetric bone mineral density and bone turnover in young men with histories of constitutional delay of puberty","volume":"83","author":"Bertelloni","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"R50-7-20211004","doi-asserted-by":"crossref","first-page":"4306","DOI":"10.1210\/jc.2004-0046","article-title":"The skeletal phenotype of men with previous constitutional delay of puberty","volume":"89","author":"Yap","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"R51-7-20211004","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1542\/peds.69.6.681","article-title":"A prospective, randomized study of testosterone treatment of constitutional delay of growth and development in male adolescents","volume":"69","author":"Rosenfeld","year":"1982","journal-title":"Pediatrics"},{"key":"R52-7-20211004","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/0026-0495(95)90098-5","article-title":"Testosterone treatment in adolescent boys with constitutional delay of growth and development","volume":"44","author":"Soliman","year":"1995","journal-title":"Metabolism"},{"key":"R53-7-20211004","first-page":"21","article-title":"Short-term testosterone treatment at bone age of 12 to 13 years does not reduce adult height in boys with constitutional delay of growth and adolescence","volume":"42","author":"Zachmann","year":"1987","journal-title":"Helv Paediatr Acta"},{"key":"R54-7-20211004","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1056\/NEJM198812153192402","article-title":"Testosterone treatment in adolescent boys with constitutional delay in growth and development","volume":"319","author":"Richman","year":"1988","journal-title":"N Engl J Med"},{"key":"R55-7-20211004","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1515\/JPEM.1995.8.2.117","article-title":"Long term treatment with low dose testosterone in constitutional delay of growth and puberty: effect on bone age maturation and pubertal progression","volume":"8","author":"Bergada","year":"1995","journal-title":"J Pediatr Endocrinol Metab"},{"key":"R56-7-20211004","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1046\/j.1365-2265.1997.t01-1-1150928.x","article-title":"Effect of low dose oxandrolone and testosterone treatment on the pituitary-testicular and GH axes in boys with constitutional delay of growth and puberty","volume":"46","author":"Crowne","year":"1997","journal-title":"Clin Endocrinol (Oxf)"},{"key":"R57-7-20211004","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1365-2265.1993.tb00520.x","article-title":"The effects of oxandrolone on the growth hormone and gonadal axes in boys with constitutional delay of growth and puberty","volume":"38","author":"Malhotra","year":"1993","journal-title":"Clin Endocrinol (Oxf)"},{"key":"R58-7-20211004","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1002\/j.1939-4640.1994.tb00433.x","article-title":"A ten-year safety study of the oral androgen testosterone undecanoate","volume":"15","author":"Gooren","year":"1994","journal-title":"J Androl"},{"key":"R60-7-20211004","first-page":"247","article-title":"An evaluation of human chorionic gonadotrophin (HCG) therapy in boys with delayed puberty","volume":"74","author":"Gordon","year":"1990","journal-title":"Q J Med"},{"issue":"Suppl 3","key":"R61-7-20211004","first-page":"345","article-title":"Constitutional delay in growth and puberty: a comparison of final height achieved between treated and untreated children","volume":"9","author":"Ferrandez","year":"1996","journal-title":"J Pediatr Endocrinol Metab"},{"key":"R62-7-20211004","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1136\/adc.65.4.448","article-title":"Treatment of constitutional delay of growth and puberty with oxandrolone compared with growth hormone","volume":"65","author":"Buyukgebiz","year":"1990","journal-title":"Arch Dis Child"},{"issue":"Suppl 1","key":"R63-7-20211004","first-page":"57","article-title":"Update on the role of aromatase inhibitors in growth disorders","volume":"71","author":"Dunkel","year":"2009","journal-title":"Horm Res"},{"key":"R64-7-20211004","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/j.1365-2265.2006.02499.x","article-title":"Treatment with the aromatase inhibitor letrozole during adolescence increases near-final height in boys with constitutional delay of puberty","volume":"64","author":"Hero","year":"2006","journal-title":"Clin Endocrinol (Oxf)"}],"container-title":["Current Opinion in Endocrinology, Diabetes & Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/01266029-200906000-00007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T03:23:39Z","timestamp":1712114619000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01266029-200906000-00007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6]]},"references-count":61,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1097\/med.0b013e32832b20a8","relation":{},"ISSN":["1752-296X"],"issn-type":[{"value":"1752-296X","type":"print"}],"subject":[],"published":{"date-parts":[[2009,6]]}}}