{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T12:06:50Z","timestamp":1791634010217,"version":"4.3.4"},"reference-count":56,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1097\/med.0b013e3283391989","type":"journal-article","created":{"date-parts":[[2011,1,14]],"date-time":"2011-01-14T01:44:43Z","timestamp":1294969483000},"page":"199-204","source":"Crossref","is-referenced-by-count":140,"title":["Aldosterone and inflammation"],"prefix":"10.1097","volume":"17","author":[{"given":"Kimberly C","family":"Gilbert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy J","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-5-20211004","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1161\/01.HYP.0000255636.11931.a2","article-title":"Podocyte as the target for aldosterone: roles of oxidative stress and Sgk1","volume":"49","author":"Shibata","year":"2007","journal-title":"Hypertension"},{"key":"R2-5-20211004","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1161\/01.CIR.0000127949.05756.9D","article-title":"Aldosterone administration to mice stimulates macrophage NADPH oxidase and increases atherosclerosis development: a possible role for angiotensin-converting enzyme and the receptors for angiotensin II and aldosterone","volume":"109","author":"Keidar","year":"2004","journal-title":"Circulation"},{"key":"R3-5-20211004","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1210\/en.2006-1157","article-title":"Angiotensin II receptor type 1-mediated vascular oxidative stress and proinflammatory gene expression in aldosterone-induced hypertension: the possible role of local renin-angiotensin system","volume":"148","author":"Hirono","year":"2007","journal-title":"Endocrinology"},{"key":"R4-5-20211004","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1161\/01.HYP.0000118519.66430.22","article-title":"Possible contributions of reactive oxygen species and mitogen-activated protein kinase to renal injury in aldosterone\/salt-induced hypertensive rats","volume":"43","author":"Nishiyama","year":"2004","journal-title":"Hypertension"},{"key":"R5-5-20211004","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/nm1545","article-title":"Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity","volume":"13","author":"Leopold","year":"2007","journal-title":"Nat Med"},{"key":"R6-5-20211004","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1161\/01.HYP.0000034738.79310.06","article-title":"Spironolactone improves angiotensin-induced vascular changes and oxidative stress","volume":"40","author":"Virdis","year":"2002","journal-title":"Hypertension"},{"key":"R7-5-20211004","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1096\/fj.05-4642fje","article-title":"Aldosterone mediates angiotensin II-induced interstitial cardiac fibrosis via a Nox2-containing NADPH oxidase","volume":"20","author":"Johar","year":"2006","journal-title":"FASEB J"},{"key":"R8-5-20211004","doi-asserted-by":"crossref","first-page":"3773","DOI":"10.1210\/en.2006-1691","article-title":"Mineralocorticoid receptor blockade attenuates chronic overexpression of the renin-angiotensin-aldosterone system stimulation of reduced nicotinamide adenine dinucleotide phosphate oxidase and cardiac remodeling","volume":"148","author":"Stas","year":"2007","journal-title":"Endocrinology"},{"key":"R9-5-20211004","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0895-7061(04)00811-8","article-title":"Involvement of oxidative stress in the profibrotic action of aldosterone. Interaction with the renin-angiotension system","volume":"17","author":"Iglarz","year":"2004","journal-title":"Am J Hypertens"},{"key":"R10-5-20211004","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/S0002-9440(10)64454-9","article-title":"Aldosterone-induced inflammation in the rat heart: role of oxidative stress","volume":"161","author":"Sun","year":"2002","journal-title":"Am J Pathol"},{"key":"R11-5-20211004","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.bbrc.2003.11.173","article-title":"NAD(P)H oxidase inhibitor prevents blood pressure elevation and cardiovascular hypertrophy in aldosterone-infused rats","volume":"313","author":"Park","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"R12-5-20211004","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1161\/01.RES.0000159937.05502.d1","article-title":"Angiotensin II and aldosterone regulate gene transcription via functional mineralocortocoid receptors in human coronary artery smooth muscle cells","volume":"96","author":"Jaffe","year":"2005","journal-title":"Circ Res"},{"key":"R13-5-20211004","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1210\/en.2006-1438","article-title":"Early aldosterone-regulated genes in cardiomyocytes: clues to cardiac remodeling?","volume":"148","author":"Fejes-Toth","year":"2007","journal-title":"Endocrinology"},{"key":"R14-5-20211004","first-page":"180","article-title":"Aldosterone up-regulates production of plasminogen activator inhibitor-1 by renal mesangial cells","volume":"40","author":"Yuan","year":"2007","journal-title":"J Biochem Mol Biol"},{"key":"R15-5-20211004","first-page":"336","article-title":"Synergistic effect of adrenal steroids and angiotensin II on plasminogen activator inhibitor-1 production","volume":"85","author":"Brown","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"R16-5-20211004","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1210\/jc.2003-031545","article-title":"Effect of aldosterone and glycyrrhetinic acid on the protein expression of PAI-1 and p22(phox) in human mononuclear leukocytes","volume":"89","author":"Calo","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"R17-5-20211004","doi-asserted-by":"crossref","first-page":"H1802","DOI":"10.1152\/ajpheart.01096.2001","article-title":"Aldosterone induces a vascular inflammatory phenotype in the rat heart","volume":"283","author":"Rocha","year":"2002","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"R18-5-20211004","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1046\/j.1523-1755.2003.00929.x","article-title":"Aldosterone\/salt induces renal inflammation and fibrosis in hypertensive rats","volume":"63","author":"Blasi","year":"2003","journal-title":"Kidney Int"},{"key":"R19-5-20211004","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1161\/01.ATV.17.6.1152","article-title":"Prevention of aortic fibrosis by spironolactone in spontaneously hypertensive rats","volume":"17","author":"Benetos","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"R20-5-20211004","doi-asserted-by":"crossref","first-page":"2848","DOI":"10.1161\/01.CIR.0000039328.33137.6C","article-title":"Increased carotid wall elastic modulus and fibronectin in aldosterone-salt-treated rats: effects of eplerenone","volume":"106","author":"Lacolley","year":"2002","journal-title":"Circulation"},{"key":"R21-5-20211004","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1139\/y05-068","article-title":"Role of aldosterone in angiotensin II-induced cardiac and aortic inflammation, fibrosis, and hypertrophy","volume":"83","author":"Neves","year":"2005","journal-title":"Can J Physiol Pharmacol"},{"key":"R22-5-20211004","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1161\/01.ATV.0000204635.75748.0f","article-title":"Eplerenone with valsartan effectively reduces atherosclerotic lesion by attenuation of oxidative stress and inflammation","volume":"26","author":"Suzuki","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"R23-5-20211004","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1161\/CIRCRESAHA.108.174235","article-title":"Functional mineralocorticoid receptors in human vascular endothelial cells regulate intercellular adhesion molecule-1 expression and promote leukocyte adhesion","volume":"102","author":"Caprio","year":"2008","journal-title":"Circ Res"},{"key":"R24-5-20211004","doi-asserted-by":"crossref","first-page":"3782","DOI":"10.1073\/pnas.0804037106","article-title":"Aldosterone activates endothelial exocytosis","volume":"106","author":"Jeong","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R25-5-20211004","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1161\/HYPERTENSIONAHA.109.141309","article-title":"Aldosterone abrogates nuclear factor kappaB-mediated tumor necrosis factor alpha production in human neutrophils via the mineralocorticoid receptor","volume":"55","author":"Bergmann","year":"2010","journal-title":"Hypertension"},{"key":"R26-5-20211004","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1210\/en.2004-1130","article-title":"Eplerenone blocks nongenomic effects of aldosterone on the Na+\/H+ exchanger, intracellular Ca2+ levels, and vasoconstriction in mesenteric resistance vessels","volume":"146","author":"Michea","year":"2005","journal-title":"Endocrinology"},{"key":"R27-5-20211004","first-page":"97","article-title":"Aldosterone: refreshing a slow hormone by swift action","volume":"19","author":"Boldyreff","year":"2004","journal-title":"News Physiol Sci"},{"key":"R28-5-20211004","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1006\/bbrc.1999.1771","article-title":"Rapid nongenomic effects of aldosterone in mineralocorticoid-receptor-knockout mice","volume":"266","author":"Haseroth","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"R29-5-20211004","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1210\/me.2004-0469","article-title":"Human mineralocorticoid receptor expression renders cells responsive for nongenotropic aldosterone actions","volume":"19","author":"Grossmann","year":"2005","journal-title":"Mol Endocrinol"},{"key":"R30-5-20211004","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1210\/en.2003-1137","article-title":"Rapid, nongenomic effects of aldosterone in the heart mediated by epsilon protein kinase C","volume":"145","author":"Mihailidou","year":"2004","journal-title":"Endocrinology"},{"key":"R31-5-20211004","doi-asserted-by":"crossref","first-page":"H1679","DOI":"10.1152\/ajpheart.2000.279.4.H1679","article-title":"PKCepsilon modulates NF-kappaB and AP-1 via mitogen-activated protein kinases in adult rabbit cardiomyocytes","volume":"279","author":"Li","year":"2000","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"R32-5-20211004","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.cellsig.2003.08.008","article-title":"CD40-mediated activation of vascular smooth muscle cell chemokine production through a Src-initiated, MAPK-dependent pathway","volume":"16","author":"Mukundan","year":"2004","journal-title":"Cell Signal"},{"key":"R33-5-20211004","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1161\/01.RES.0000180753.63183.95","article-title":"Aldosterone and angiotensin II synergistically induce mitogenic response in vascular smooth muscle cells","volume":"97","author":"Min","year":"2005","journal-title":"Circ Res"},{"key":"R34-5-20211004","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.1161\/01.CIR.0000131860.80444.AB","article-title":"Aldosterone potentiates angiotensin II-induced signaling in vascular smooth muscle cells","volume":"109","author":"Mazak","year":"2004","journal-title":"Circulation"},{"key":"R35-5-20211004","doi-asserted-by":"crossref","first-page":"E1790","DOI":"10.1152\/ajpendo.00708.2006","article-title":"Aldosterone-induced EGFR expression: interaction between the human mineralocorticoid receptor and the human EGFR promoter","volume":"292","author":"Grossmann","year":"2007","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"R36-5-20211004","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1161\/CIRCRESAHA.109.196576","article-title":"Aldosterone-induced activation of signaling pathways requires activity of angiotensin type 1a receptors","volume":"105","author":"Lemarie","year":"2009","journal-title":"Circ Res"},{"key":"R37-5-20211004","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1681\/ASN.2008020232","article-title":"Aldosterone activates NF-kappaB in the collecting duct","volume":"20","author":"Leroy","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"R38-5-20211004","doi-asserted-by":"crossref","first-page":"25671","DOI":"10.1074\/jbc.M803812200","article-title":"NF-kappaB inhibits sodium transport via down-regulation of SGK1 in renal collecting duct principal cells","volume":"283","author":"de Seigneux","year":"2008","journal-title":"J Biol Chem"},{"key":"R39-5-20211004","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s00424-006-0123-0","article-title":"Regulation of NaCl transport in the renal collecting duct: lessons from cultured cells","volume":"453","author":"Bens","year":"2006","journal-title":"Pflugers Arch"},{"key":"R40-5-20211004","doi-asserted-by":"crossref","first-page":"36586","DOI":"10.1074\/jbc.M805676200","article-title":"Plasmin activates epithelial Na channels by cleaving the gamma subunit.","volume":"283","author":"Passero","year":"2008","journal-title":"J Biol Chem"},{"key":"R41-5-20211004","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1161\/CIRCRESAHA.108.176008","article-title":"Identification of a retinal aldosterone system and the protective effects of mineralocorticoid receptor antagonism on retinal vascular pathology","volume":"104","author":"Wilkinson-Berka","year":"2009","journal-title":"Circ Res"},{"key":"R42-5-20211004","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/nm877","article-title":"Leukocytes mediate retinal vascular remodeling during development and vaso-obliteration in disease","volume":"9","author":"Ishida","year":"2003","journal-title":"Nat Med"},{"key":"R44-5-20211004","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1161\/HYPERTENSIONAHA.109.131110","article-title":"Deletion of mineralocorticoid receptors from macrophages protects against deoxycorticosterone\/salt-induced cardiac fibrosis and increased blood pressure","volume":"54","author":"Rickard","year":"2009","journal-title":"Hypertension"},{"key":"R45-5-20211004","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1084\/jem.20070657","article-title":"Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction","volume":"204","author":"Guzik","year":"2007","journal-title":"J Exp Med"},{"key":"R46-5-20211004","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1161\/HYPERTENSIONAHA.109.145094","article-title":"Interleukin 17 promotes angiotensin II-induced hypertension and vascular dysfunction","volume":"55","author":"Madhur","year":"2010","journal-title":"Hypertension"},{"key":"R47-5-20211004","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1161\/01.RES.0000080521.15238.E5","article-title":"Transgenic model of aldosterone-driven cardiac hypertrophy and heart failure","volume":"93","author":"Qin","year":"2003","journal-title":"Circ Res"},{"key":"R48-5-20211004","first-page":"2946","article-title":"Mineralocorticoid receptor mediates heart failure in the 11 ss-hydroxysteroid dehydrogenase type 2 transgenic mouse model","volume":"110","author":"Qin","year":"2004","journal-title":"Circulation"},{"key":"R49-5-20211004","doi-asserted-by":"crossref","first-page":"E110","DOI":"10.1152\/ajpendo.00258.2007","article-title":"Low-dose spironolactone reduces reactive oxygen species generation and improves insulin-stimulated glucose transport in skeletal muscle in the TG(mRen2)27 rat","volume":"295","author":"Lastra","year":"2008","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"R50-5-20211004","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1677\/JOE-09-0292","article-title":"The balance between gluco- and mineralo-corticoid action critically determines inflammatory adipocyte responses","volume":"204","author":"Hoppmann","year":"2010","journal-title":"J Endocrinol"},{"key":"R51-5-20211004","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1093\/cvr\/cvp191","article-title":"Blockade of mineralocorticoid receptor reverses adipocyte dysfunction and insulin resistance in obese mice","volume":"84","author":"Hirata","year":"2009","journal-title":"Cardiovasc Res"},{"key":"R52-5-20211004","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1161\/CIRCULATIONAHA.107.748640","article-title":"Mineralocorticoid receptor blockade reverses obesity-related changes in expression of adiponectin, peroxisome proliferator-activated receptor-gamma, and proinflammatory adipokines","volume":"117","author":"Guo","year":"2008","journal-title":"Circulation"},{"key":"R53-5-20211004","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1210\/en.2008-1296","article-title":"Endogenous aldosterone contributes to acute angiotensin II-stimulated plasminogen activator inhibitor-1 and preproendothelin-1 expression in heart but not aorta","volume":"150","author":"Luther","year":"2009","journal-title":"Endocrinology"},{"key":"R54-5-20211004","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.1161\/CIRCULATIONAHA.104.521625","article-title":"Aldosterone synthase inhibitor ameliorates angiotensin II-induced organ damage","volume":"111","author":"Fiebeler","year":"2005","journal-title":"Circulation"},{"key":"R55-5-20211004","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1038\/ki.2009.9","article-title":"Aldosterone antagonism or synthase inhibition reduces end-organ damage induced by treatment with angiotensin and high salt","volume":"75","author":"Lea","year":"2009","journal-title":"Kidney Int"},{"key":"R56-5-20211004","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1113\/expphysiol.2009.048900","article-title":"Aldosterone synthesis in the brain contributes to Dahl salt-sensitive rat hypertension","volume":"95","author":"Gomez-Sanchez","year":"2010","journal-title":"Exp Physiol"},{"key":"R57-5-20211004","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ab.2009.07.025","article-title":"Coexpression of CYP11B2 or CYP11B1 with adrenodoxin and adrenodoxin reductase for assessing the potency and selectivity of aldosterone synthase inhibitors","volume":"394","author":"LaSala","year":"2009","journal-title":"Anal Biochem"}],"container-title":["Current Opinion in Endocrinology, Diabetes & Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/01266029-201006000-00005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,3]],"date-time":"2021-10-03T21:05:22Z","timestamp":1633295122000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01266029-201006000-00005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":56,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1097\/med.0b013e3283391989","relation":{},"ISSN":["1752-296X"],"issn-type":[{"value":"1752-296X","type":"print"}],"subject":[],"published":{"date-parts":[[2010,6]]}}}