{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:28:44Z","timestamp":1761895724742},"reference-count":48,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1097\/med.0b013e32834a91d1","type":"journal-article","created":{"date-parts":[[2013,8,30]],"date-time":"2013-08-30T16:11:58Z","timestamp":1377879118000},"page":"304-309","source":"Crossref","is-referenced-by-count":11,"title":["Management of hypothyroidism in pregnancy"],"prefix":"10.1097","volume":"18","author":[{"given":"Anna","family":"Milanesi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory A.","family":"Brent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R3-5-20211004","first-page":"526","article-title":"Serum TSH determinations in pregnancy: how, when and why Nat Rev E","volume":"6","author":"Glinoer","year":"2010","journal-title":"ndocrinol"},{"key":"R4-5-20211004","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1159\/000313301","article-title":"Maternal thyroid function at 11-13 weeks of gestation.","volume":"27","author":"Ashoor","year":"2010","journal-title":"Fetal Diagn Ther"},{"key":"R5-5-20211004","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1089\/thy.2009.0356","article-title":"Parameters of thyroid function throughout and after pregnancy in an iodine-deficient population.","volume":"20","author":"Costeira","year":"2010","journal-title":"Thyroid"},{"key":"R6-5-20211004","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/j.1365-2265.2010.03910.x","article-title":"Trimester- and method-specific reference intervals for thyroid tests in pregnant Chinese women: methodology, euthyroid definition and iodine status can influence the setting of reference intervals.","volume":"74","author":"Yan","year":"2011","journal-title":"Clin Endocrinol (Oxf)"},{"key":"R7-5-20211004","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1089\/thy.2010.0337","article-title":"Early pregnancy reference intervals of thyroid hormone concentrations in a thyroid antibody-negative pregnant population.","volume":"21","author":"Mannisto","year":"2011","journal-title":"Thyroid"},{"key":"R8-5-20211004","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1530\/EJE-10-0516","article-title":"Universal screening detects two-times more thyroid disorders in early pregnancy than targeted high-risk case finding.","volume":"163","author":"Horacek","year":"2010","journal-title":"Eur J Endocrinol"},{"key":"R9-5-20211004","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1530\/EJE-10-0660","article-title":"The prevalence of thyroid disorders during early pregnancy in China: the benefits of universal screening in the first trimester of pregnancy.","volume":"164","author":"Wang","year":"2011","journal-title":"Eur J Endocrinol"},{"key":"R10-5-20211004","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1210\/jc.2009-2009","article-title":"Universal screening versus case finding for detection and treatment of thyroid hormonal dysfunction during pregnancy.","volume":"95","author":"Negro","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"R11-5-20211004","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1600-0897.2010.00911.x","article-title":"Thyroid autoimmunity and its association with cellular and humoral immunity in women with reproductive failures.","volume":"65","author":"Kim","year":"2011","journal-title":"Am J Reprod Immunol"},{"key":"R12-5-20211004","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1007\/s12016-010-8201-7","article-title":"The role of NK cells in the autoimmune thyroid disease-associated pregnancy loss.","volume":"39","author":"Konova","year":"2010","journal-title":"Clin Rev Allergy Immunol"},{"key":"R13-5-20211004","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/j.1365-2265.2010.03974.x","article-title":"Thyroid autoimmunity and miscarriage: a meta-analysis.","volume":"74","author":"Chen","year":"2011","journal-title":"Clin Endocrinol (Oxf)"},{"key":"R14-5-20211004","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1530\/EJE-09-0850","article-title":"Risk of spontaneous miscarriage in euthyroid women with thyroid autoimmunity undergoing IVF: a meta-analysis.","volume":"162","author":"Toulis","year":"2010","journal-title":"Eur J Endocrinol"},{"key":"R15-5-20211004","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1210\/jc.2008-1520","article-title":"Perinatal outcome of children born to mothers with thyroid dysfunction or antibodies: a prospective population-based cohort study.","volume":"94","author":"Mannisto","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"R18-5-20211004","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1089\/thy.2010.0058","article-title":"Maternal thyroid function at 11 to 13 weeks of gestation and subsequent fetal death.","volume":"20","author":"Ashoor","year":"2010","journal-title":"Thyroid"},{"key":"R19-5-20211004","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1210\/jc.2009-1904","article-title":"Thyroid dysfunction and autoantibodies during pregnancy as predictive factors of pregnancy complications and maternal morbidity in later life.","volume":"95","author":"Mannisto","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"R20-5-20211004","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1210\/jc.2005-1603","article-title":"Levothyroxine treatment in euthyroid pregnant women with autoimmune thyroid disease: effects on obstetrical complications.","volume":"91","author":"Negro","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"R21-5-20211004","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/1477-7827-7-137","article-title":"A retrospective study on IVF outcome in euthyroid patients with antithyroid antibodies: effects of levothyroxine, acetyl-salicylic acid and prednisolone adjuvant treatments.","volume":"7","author":"Revelli","year":"2009","journal-title":"Reprod Biol Endocrinol"},{"key":"R22-5-20211004","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1210\/jcem.87.4.8421","article-title":"Selenium supplementation in patients with autoimmune thyroiditis decreases thyroid peroxidase antibodies concentrations.","volume":"87","author":"Gartner","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"R23-5-20211004","first-page":"535","article-title":"Influence of physiological dietary selenium supplementation on the natural course of autoimmune thyroiditis.","volume":"73","author":"Nacamulli","year":"2010","journal-title":"Clin Endocrinol (Oxf)"},{"key":"R24-5-20211004","doi-asserted-by":"crossref","first-page":"5180","DOI":"10.1210\/jc.2010-0191","article-title":"Selenium and the thyroid: a close-knit connection.","volume":"95","author":"Duntas","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"R25-5-20211004","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1210\/jc.2006-1821","article-title":"The influence of selenium supplementation on postpartum thyroid status in pregnant women with thyroid peroxidase autoantibodies.","volume":"92","author":"Negro","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"R27-5-20211004","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1089\/thy.2009.0323","article-title":"Thyroid function in women found to have early pregnancy loss.","volume":"20","author":"De Vivo","year":"2010","journal-title":"Thyroid"},{"key":"R28-5-20211004","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1089\/105072502753451986","article-title":"Overt and subclinical hypothyroidism complicating pregnancy.","volume":"12","author":"Abalovich","year":"2002","journal-title":"Thyroid"},{"key":"R29-5-20211004","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1002\/pd.2566","article-title":"Maternal thyroid function at 11 to 13 weeks of gestation and subsequent development of preeclampsia.","volume":"30","author":"Ashoor","year":"2010","journal-title":"Prenat Diagn"},{"key":"R30-5-20211004","first-page":"54","article-title":"Is an upper limit of 2.","volume":"26","author":"Felipe","year":"2010","journal-title":"5mUIl for TSH appropriate for the first trimester of pregnancy among young TPO: women Gynecol Endocrinol"},{"key":"R31-5-20211004","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1016\/j.fertnstert.2010.06.041","article-title":"What is a normal thyroid-stimulating hormone (TSH) level Effects of stricter TSH thresholds on pregnancy outcomes after in vitro fertilization.","volume":"94","author":"Reh","year":"2010","journal-title":"Fertil Steril"},{"key":"R32-5-20211004","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1016\/j.fertnstert.2011.02.056","article-title":"Subclinical elevations of thyroid-stimulating hormone and assisted reproductive technology outcomes.","volume":"95","author":"Michalakis","year":"2011","journal-title":"Fertil Steril"},{"key":"R33-5-20211004","doi-asserted-by":"crossref","first-page":"792","DOI":"10.4158\/EP09365.OR","article-title":"Improved in vitro fertilization outcomes after treatment of subclinical hypothyroidism in infertile women.","volume":"16","author":"Abdel Rahman","year":"2010","journal-title":"Endocr Pract"},{"key":"R34-5-20211004","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1016\/j.fertnstert.2010.12.004","article-title":"Effect of levothyroxine treatment on in vitro fertilization and pregnancy outcome in infertile women with subclinical hypothyroidism undergoing in vitro fertilizationintracytoplasmic sperm injection.","volume":"95","author":"Kim","year":"2011","journal-title":"Fertil Steril"},{"key":"R35-5-20211004","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1365-2826.2009.01947.x","article-title":"The nature of the compensatory response to low thyroid hormone in the developing brain.","volume":"22","author":"Sharlin","year":"2010","journal-title":"J Neuroendocrinol"},{"key":"R36-5-20211004","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.expneurol.2010.12.012","article-title":"Effect of hypothyroxinemia on thyroid hormone responsiveness and action during rat postnatal neocortical development.","volume":"228","author":"Babu","year":"2011","journal-title":"Exp Neurol"},{"key":"R37-5-20211004","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1210\/en.2010-1014","article-title":"Lack of action of exogenously administered t3 on the fetal rat brain despite expression of the monocarboxylate transporter 8.","volume":"152","author":"Grijota-Martinez","year":"2011","journal-title":"Endocrinology"},{"key":"R38-5-20211004","doi-asserted-by":"crossref","first-page":"4227","DOI":"10.1210\/jc.2010-0415","article-title":"Maternal thyroid function during early pregnancy and cognitive functioning in early childhood: the generation R study.","volume":"95","author":"Henrichs","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"R39-5-20211004","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1111\/j.1365-2265.2009.03743.x","article-title":"Abnormalities of maternal thyroid function during pregnancy affect neuropsychological development of their children at 25-30 months.","volume":"72","author":"Li","year":"2010","journal-title":"Clin Endocrinol (Oxf)"},{"key":"R41-5-20211004","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1530\/EJE-10-0449","article-title":"Iodine intake in Portuguese pregnant women: results of a countrywide study.","volume":"163","author":"Limbert","year":"2010","journal-title":"Eur J Endocrinol"},{"key":"R42-5-20211004","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1089\/thy.2010.0046","article-title":"Patterns of iodine intake and urinary iodine concentrations during pregnancy and blood thyroid-stimulating hormone concentrations in the newborn progeny.","volume":"20","author":"Marco","year":"2010","journal-title":"Thyroid"},{"key":"R43-5-20211004","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.3945\/jn.109.120147","article-title":"Some subgroups of reproductive age women in the United States may be at risk for iodine deficiency.","volume":"140","author":"Perrine","year":"2010","journal-title":"J Nutr"},{"key":"R44-5-20211004","first-page":"250","article-title":"Poor iodine status and knowledge related to iodine on the eve of mandatory iodine fortification in Australia.","volume":"19","author":"Charlton","year":"2010","journal-title":"Asia Pac J Clin Nutr"},{"key":"R45-5-20211004","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.ijdevneu.2010.07.230","article-title":"Hypothyroidism following developmental iodine deficiency reduces hippocampal neurogranin, CaMK II and calmodulin and elevates calcineurin in lactational rats.","volume":"28","author":"Dong","year":"2010","journal-title":"Int J Dev Neurosci"},{"key":"R46-5-20211004","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.beem.2009.09.002","article-title":"Iodine deficiency in pregnancy, infancy and childhood and its consequences for brain development.","volume":"24","author":"Melse-Boonstra","year":"2010","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"R47-5-20211004","doi-asserted-by":"crossref","first-page":"314","DOI":"10.3109\/09513590.2010.491166","article-title":"Perinatal outcomes in postthyroidectomy pregnancies.","volume":"27","author":"Cohen","year":"2011","journal-title":"Gynecol Endocrinol"},{"key":"R48-5-20211004","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1111\/j.1365-2265.2009.03729.x","article-title":"Maternal thyroid function during gestation is related to breech presentation at term.","volume":"72","author":"Kuppens","year":"2010","journal-title":"Clinical Endocrinology"},{"key":"R49-5-20211004","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1471-2393-11-10","article-title":"Maternal thyroid function and the outcome of external cephalic version: a prospective cohort study.","volume":"11","author":"Kuppens","year":"2011","journal-title":"BMC Pregnancy Childbirth"},{"key":"R50-5-20211004","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1159\/000314906","article-title":"Maternal thyroid function at 11-13 weeks of gestation in women with hypothyroidism treated by thyroxine.","volume":"28","author":"Ashoor","year":"2010","journal-title":"Fetal Diagn Ther"},{"key":"R51-5-20211004","doi-asserted-by":"crossref","first-page":"3234","DOI":"10.1210\/jc.2010-0013","article-title":"Thyroid hormone early adjustment in pregnancy (the THERAPY) trial.","volume":"95","author":"Yassa","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"R52-5-20211004","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/nrendo.2010.149","article-title":"Thyroid gland: early adjustment of levothyroxine treatment in pregnancy.","volume":"6","author":"Chan","year":"2010","journal-title":"Nat Rev Endocrinol"},{"key":"R53-5-20211004","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1089\/thy.2009.0457","article-title":"The relationship of preconception thyrotropin levels to requirements for increasing the levothyroxine dose during pregnancy in women with primary hypothyroidism.","volume":"20","author":"Abalovich","year":"2010","journal-title":"Thyroid"},{"key":"R54-5-20211004","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1089\/thy.2008.0413","article-title":"The magnitude of increased levothyroxine requirements in hypothyroid pregnant women depends upon the etiology of the hypothyroidism.","volume":"19","author":"Loh","year":"2009","journal-title":"Thyroid"}],"container-title":["Current Opinion in Endocrinology, Diabetes & Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/01266029-201110000-00005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T01:44:22Z","timestamp":1633311862000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01266029-201110000-00005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1097\/med.0b013e32834a91d1","relation":{},"ISSN":["1752-296X"],"issn-type":[{"value":"1752-296X","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]}}}