{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:10:12Z","timestamp":1791177012340,"version":"4.1.0"},"reference-count":88,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1097\/med.0b013e32835a1a03","type":"journal-article","created":{"date-parts":[[2013,8,30]],"date-time":"2013-08-30T16:02:04Z","timestamp":1377878524000},"page":"497-504","source":"Crossref","is-referenced-by-count":31,"title":["Diagnosis and treatment of polycystic ovarian syndrome in adolescents"],"prefix":"10.1097","volume":"19","author":[{"given":"Katrina F.","family":"Nicandri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Hoeger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-10-20211004","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0002-9378(15)30642-6","article-title":"Amenorrhea associated with bilateral polycystic ovaries.","volume":"29","author":"Stein","year":"1935","journal-title":"Am J Obstet Gynecol"},{"key":"R2-10-20211004","first-page":"3078","article-title":"Prevalence of the polycystic ovary syndrome in unselected black and white women of the southeastern United States: a prospective study.","volume":"83","author":"Knochenhauer","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"R3-10-20211004","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1056\/NEJMra041536","article-title":"Polycystic ovary syndrome.","volume":"352","author":"Ehrmann","year":"2005","journal-title":"N Engl J Med"},{"key":"R4-10-20211004","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1053\/beem.2002.0203","article-title":"Adult polycystic ovary syndrome begins in childhood.","volume":"16","author":"Franks","year":"2002","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"R5-10-20211004","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jpag.2010.06.003","article-title":"Age of onset of polycystic ovarian syndrome in girls may be earlier than previously thought.","volume":"24","author":"Bronstein","year":"2011","journal-title":"J Pediatr Adolesc Gynecol"},{"key":"R7-10-20211004","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fertnstert.2003.10.004","article-title":"Revised 2003 Consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome.","volume":"81","year":"2004","journal-title":"Fertil Steril"},{"key":"R8-10-20211004","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.fertnstert.2008.06.035","article-title":"The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report.","volume":"91","author":"Azziz","year":"2009","journal-title":"Fertil Steril"},{"key":"R9-10-20211004","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1016\/j.fertnstert.2011.09.043","article-title":"Blood pressure regulation and resting heart rate abnormalities in adolescent girls with polycystic ovary syndrome.","volume":"96","author":"Zachurzok-Buczynska","year":"2011","journal-title":"Fertil Steril"},{"key":"R10-10-20211004","first-page":"1021","article-title":"Rapid maturation of the reproductive axis during perimenarche independent of body composition.","volume":"85","author":"Legro","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"R11-10-20211004","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1203\/01.pdr.0000246097.73031.27","article-title":"Longitudinal study of physiologic insulin resistance and metabolic changes of puberty.","volume":"60","author":"Hannon","year":"2006","journal-title":"Pediatr Res"},{"key":"R12-10-20211004","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1210\/jc.2006-2012","article-title":"Clinical review: identifying children at risk for polycystic ovary syndrome.","volume":"92","author":"Rosenfield","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"R13-10-20211004","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1210\/jc.2005-2501","article-title":"Controversy in clinical endocrinology: diagnosis of polycystic ovarian syndrome: in defense of the Rotterdam criteria.","volume":"91","author":"Franks","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"R14-10-20211004","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1093\/humrep\/der102","article-title":"Clinical, ultrasound and biochemical features of polycystic ovary syndrome in adolescents: implications for diagnosis.","volume":"26","author":"Hickey","year":"2011","journal-title":"Hum Reprod"},{"key":"R15-10-20211004","doi-asserted-by":"crossref","first-page":"3786","DOI":"10.1210\/jc.2006-0835","article-title":"Functional significance of polycystic-size ovaries in healthy adolescents.","volume":"91","author":"Mortensen","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"R16-10-20211004","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0015-0282(00)00584-7","article-title":"Polycystic ovaries in adolescents and the relationship with menstrual cycle patterns, luteinizing hormone, androgens, and insulin.","volume":"74","author":"van Hooff","year":"2000","journal-title":"Fertil Steril"},{"key":"R17-10-20211004","doi-asserted-by":"crossref","first-page":"28e25","DOI":"10.1016\/j.fertnstert.2011.09.024","article-title":"Consensus on womens health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHREASRM-Sponsored 3rd PCOS Consensus Workshop Group.","volume":"97","author":"Fauser","year":"2012","journal-title":"Fertil Steril"},{"key":"R18-10-20211004","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1093\/humrep\/deh079","article-title":"Predictive value of menstrual cycle pattern, body mass index, hormone levels and polycystic ovaries at age 15 years for oligo-amenorrhoea at age 18 years.","volume":"19","author":"van Hooff","year":"2004","journal-title":"Hum Reprod"},{"key":"R19-10-20211004","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.fertnstert.2008.06.004","article-title":"Adolescent girls with polycystic ovary syndrome showing different phenotypes have a different metabolic profile associated with increasing androgen levels.","volume":"92","author":"Fruzzetti","year":"2009","journal-title":"Fertil Steril"},{"key":"R20-10-20211004","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1210\/jcem-66-1-165","article-title":"Hyperfunction of the hypothalamic-pituitary axis in women with polycystic ovarian disease: indirect evidence for partial gonadotroph desensitization.","volume":"66","author":"Waldstreicher","year":"1988","journal-title":"J Clin Endocrinol Metab"},{"key":"R21-10-20211004","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1210\/endo-128-1-509","article-title":"A pulsatile gonadotropin-releasing hormone stimulus is required to increase transcription of the gonadotropin subunit genes: evidence for differential regulation of transcription by pulse frequency in vivo.","volume":"128","author":"Haisenleder","year":"1991","journal-title":"Endocrinology"},{"key":"R22-10-20211004","first-page":"2248","article-title":"Determinants of abnormal gonadotropin secretion in clinically defined women with polycystic ovary syndrome.","volume":"82","author":"Taylor","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"R23-10-20211004","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000134751","article-title":"Steroidogenic enzymes.","volume":"13","author":"Miller","year":"2008","journal-title":"Endocr Dev"},{"key":"R24-10-20211004","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jsbmb.2009.12.010","article-title":"Insulin and hyperandrogenism in women with polycystic ovary syndrome.","volume":"122","author":"Baptiste","year":"2010","journal-title":"J Steroid Biochem Mol Biol"},{"key":"R25-10-20211004","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2337\/diacare.22.1.141","article-title":"Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome.","volume":"22","author":"Ehrmann","year":"1999","journal-title":"Diabetes Care"},{"key":"R26-10-20211004","first-page":"165","article-title":"Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective, controlled study in 254 affected women.","volume":"84","author":"Legro","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"R27-10-20211004","first-page":"2001","article-title":"Insulin stimulates testosterone biosynthesis by human thecal cells from women with polycystic ovary syndrome by activating its own receptor and using inositolglycan mediators as the signal transduction system.","volume":"83","author":"Nestler","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"R28-10-20211004","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0303-7207(98)00177-4","article-title":"Role of cytochrome P450c17 in polycystic ovary syndrome.","volume":"145","author":"Qin","year":"1998","journal-title":"Mol Cell Endocrinol"},{"key":"R29-10-20211004","first-page":"302","article-title":"Modulation by insulin of follicle-stimulating hormone and luteinizing hormone actions in human granulosa cells of normal and polycystic ovaries.","volume":"81","author":"Willis","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"R30-10-20211004","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1210\/jc.2011-2939","article-title":"Hyperinsulinemia amplifies GnRH agonist stimulated ovarian steroid secretion in women with polycystic ovary syndrome.","volume":"97","author":"Tosi","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"R31-10-20211004","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s11892-011-0189-8","article-title":"Adipose tissue dysfunction in polycystic ovary syndrome.","volume":"11","author":"Villa","year":"2011","journal-title":"Curr Diabetes Rep"},{"key":"R32-10-20211004","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/j.metabol.2007.06.027","article-title":"Leptin secretory burst mass correlates with body mass index and insulin in normal women but not in women with polycystic ovary syndrome.","volume":"56","author":"Iuorno","year":"2007","journal-title":"Metabolism"},{"key":"R33-10-20211004","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/j.fertnstert.2009.04.055","article-title":"Visfatin and leptin levels in women with polycystic ovaries undergoing ovarian stimulation.","volume":"94","author":"Plati","year":"2010","journal-title":"Fertil Steril"},{"key":"R34-10-20211004","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.fertnstert.2011.04.073","article-title":"Serum retinol-binding protein 4, leptin, and plasma asymmetric dimethylarginine levels in obese and nonobese young women with polycystic ovary syndrome.","volume":"96","author":"Yildizhan","year":"2011","journal-title":"Fertil Steril"},{"key":"R35-10-20211004","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1210\/jc.2009-1557","article-title":"High-molecular-weight adiponectin is selectively reduced in women with polycystic ovary syndrome independent of body mass index and severity of insulin resistance.","volume":"95","author":"OConnor","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"R36-10-20211004","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ejogrb.2010.08.022","article-title":"Serum adiponectin and resistin in relation to insulin resistance and markers of hyperandrogenism in lean and obese women with polycystic ovary syndrome.","volume":"154","author":"Olszanecka-Glinianowicz","year":"2011","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"R37-10-20211004","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1159\/000151396","article-title":"Expression of adiponectin and adiponectin receptors in human pituitary gland and brain.","volume":"89","author":"Psilopanagioti","year":"2009","journal-title":"Neuroendocrinology"},{"key":"R38-10-20211004","first-page":"55","article-title":"Are plasma levels of visfatin and retinol-binding protein 4 (RBP4) associated with body mass, metabolic and hormonal disturbances in women with polycystic ovary syndrome Eur J Obstet Gynecol Reprod B","volume":"162","author":"Olszanecka-Glinianowicz","year":"2012","journal-title":"iol"},{"key":"R39-10-20211004","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.fertnstert.2012.01.111","article-title":"Metabolic manifestations of polycystic ovary syndrome in nonobese adolescents: retinol-binding protein 4 and ectopic fat deposition.","volume":"97","author":"Sopher","year":"2012","journal-title":"Fertil Steril"},{"key":"R40-10-20211004","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1210\/jcem-70-1-16","article-title":"An immunoassay to detect human mullerian inhibiting substance in males and females during normal development.","volume":"70","author":"Hudson","year":"1990","journal-title":"J Clin Endocrinol Metab"},{"key":"R41-10-20211004","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1093\/humrep\/dep366","article-title":"Comparison of inter- and intra-cycle variability of anti-Mullerian hormone and antral follicle counts.","volume":"25","author":"van Disseldorp","year":"2010","journal-title":"Hum Reprod"},{"key":"R42-10-20211004","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.fertnstert.2011.06.016","article-title":"Evaluation of serum antimullerian hormone and inhibin B concentrations in the differential diagnosis of secondary oligoamenorrhea.","volume":"96","author":"Li","year":"2011","journal-title":"Fertil Steril"},{"key":"R43-10-20211004","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.fertnstert.2012.03.059","article-title":"Antimullerian hormone levels are independently related to ovarian hyperandrogenism and polycystic ovaries.","volume":"98","author":"Rosenfield","year":"2012","journal-title":"Fertil Steril"},{"key":"R44-10-20211004","doi-asserted-by":"crossref","first-page":"77e71","DOI":"10.1016\/j.ajog.2006.07.046","article-title":"Mullerian inhibiting substance and disrupted folliculogenesis in polycystic ovary syndrome.","volume":"196","author":"Wang","year":"2007","journal-title":"Am J Obstet Gynecol"},{"key":"R45-10-20211004","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1016\/j.fertnstert.2007.03.066","article-title":"Mullerian-inhibiting substance inhibits cytochrome P450 aromatase activity in human granulosa lutein cell culture.","volume":"89","author":"Grossman","year":"2008","journal-title":"Fertil Steril"},{"key":"R46-10-20211004","first-page":"254","article-title":"Is the plasma anti-Mullerian hormone (AMH) level associated with body weight and metabolic, and hormonal disturbances in women with and without polycystic ovary syndrome Eur J Obstet Gynecol Reprod B","volume":"158","author":"Skalba","year":"2011","journal-title":"iol"},{"key":"R47-10-20211004","doi-asserted-by":"crossref","first-page":"5957","DOI":"10.1210\/jc.2003-030727","article-title":"Elevated serum level of antimullerian hormone in patients with polycystic ovary syndrome: relationship to the ovarian follicle excess and to the follicular arrest.","volume":"88","author":"Pigny","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"R48-10-20211004","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.fertnstert.2011.12.028","article-title":"Developmental programming: prenatal testosterone excess disrupts anti-Mullerian hormone expression in preantral and antral follicles.","volume":"97","author":"Veiga-Lopez","year":"2012","journal-title":"Fertil Steril"},{"key":"R49-10-20211004","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.fertnstert.2011.10.002","article-title":"Improvement of hyperandrogenism and hyperinsulinemia during pregnancy in women with polycystic ovary syndrome: possible effect in the ovarian follicular mass of their daughters.","volume":"97","author":"Crisosto","year":"2012","journal-title":"Fertil Steril"},{"key":"R50-10-20211004","first-page":"129","article-title":"Hormonal abnormalities in first-degree relatives of women with polycystic ovary syndrome (PCOS).","volume":"62","author":"Lenarcik","year":"2011","journal-title":"Endokrynol Pol"},{"key":"R51-10-20211004","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1210\/jcem.87.5.8513","article-title":"Insulin resistance in the sisters of women with polycystic ovary syndrome: association with hyperandrogenemia rather than menstrual irregularity.","volume":"87","author":"Legro","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"R52-10-20211004","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1210\/jc.2007-0267","article-title":"Anti-Mullerian hormone levels in peripubertal daughters of women with polycystic ovary syndrome.","volume":"92","author":"Crisosto","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"R53-10-20211004","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1177\/1933719111424444","article-title":"Relationship between anti-Mullerian hormone (AMH) and insulin levels during different tanner stages in daughters of women with polycystic ovary syndrome.","volume":"19","author":"Sir-Petermann","year":"2012","journal-title":"Reprod Sci"},{"key":"R54-10-20211004","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.1210\/jc.2007-1036","article-title":"Early metabolic derangements in daughters of women with polycystic ovary syndrome.","volume":"92","author":"Sir-Petermann","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"R55-10-20211004","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1095\/biolreprod.109.082719","article-title":"Developmental programming: effect of prenatal steroid excess on intraovarian components of insulin signaling pathway and related proteins in sheep.","volume":"82","author":"Ortega","year":"2010","journal-title":"Biol Reprod"},{"key":"R56-10-20211004","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1002\/ajp.20679","article-title":"Fetal, infant, adolescent and adult phenotypes of polycystic ovary syndrome in prenatally androgenized female rhesus monkeys.","volume":"71","author":"Abbott","year":"2009","journal-title":"Am J Primatol"},{"key":"R57-10-20211004","doi-asserted-by":"crossref","first-page":"e27286","DOI":"10.1371\/journal.pone.0027286","article-title":"Epigenetic mechanism underlying the development of polycystic ovary syndrome (PCOS)-like phenotypes in prenatally androgenized rhesus monkeys.","volume":"6","author":"Xu","year":"2011","journal-title":"PLoS One"},{"key":"R58-10-20211004","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/ng.732","article-title":"Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3.","volume":"43","author":"Chen","year":"2011","journal-title":"Nat Genet"},{"key":"R59-10-20211004","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1093\/humrep\/der379","article-title":"Family-based analysis of susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3.","volume":"27","author":"Zhao","year":"2012","journal-title":"Hum Reprod"},{"key":"R60-10-20211004","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1055\/s-0031-1286279","article-title":"Susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21, and 9q33.3 in a cohort of Caucasian women.","volume":"43","author":"Lerchbaum","year":"2011","journal-title":"Horm Metab Res"},{"key":"R61-10-20211004","doi-asserted-by":"crossref","first-page":"e16390","DOI":"10.1371\/journal.pone.0016390","article-title":"FTO and MC4R gene variants are associated with obesity in polycystic ovary syndrome.","volume":"6","author":"Ewens","year":"2011","journal-title":"PLoS One"},{"key":"R62-10-20211004","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.metabol.2009.08.023","article-title":"Association of FTO gene with hyperandrogenemia and metabolic parameters in women with polycystic ovary syndrome.","volume":"59","author":"Wehr","year":"2010","journal-title":"Metabolism"},{"key":"R63-10-20211004","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1471-2350-11-12","article-title":"Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS).","volume":"11","author":"Tan","year":"2010","journal-title":"BMC Med Genet"},{"key":"R64-10-20211004","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1016\/j.fertnstert.2011.01.015","article-title":"Replication of association of a novel insulin receptor gene polymorphism with polycystic ovary syndrome.","volume":"95","author":"Goodarzi","year":"2011","journal-title":"Fertil Steril"},{"key":"R65-10-20211004","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1365-2265.2012.04389.x","article-title":"Polycystic ovary syndrome is not associated with polymorphisms of the TCF7L2, CDKAL1, HHEX, KCNJ11, FTO and SLC30A8 genes.","volume":"77","author":"Kim","year":"2012","journal-title":"Clin Endocrinol"},{"key":"R66-10-20211004","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jpag.2007.07.007","article-title":"Polycystic ovary syndrome in adolescents.","volume":"21","author":"OBrien","year":"2008","journal-title":"J Pediatr Adolesc Gynecol"},{"key":"R67-10-20211004","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2217\/phe.09.69","article-title":"Interventional studies for polycystic ovarian syndrome in children and adolescents.","volume":"4","author":"Vuguin","year":"2010","journal-title":"Pediatr health"},{"key":"R68-10-20211004","first-page":"774","article-title":"Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis.","volume":"18","author":"Dunaif","year":"1997","journal-title":"Endocr Rev"},{"key":"R69-10-20211004","doi-asserted-by":"crossref","first-page":"4780","DOI":"10.1210\/jc.2008-1198","article-title":"Prevalence of metabolic syndrome and related characteristics in obese adolescents with and without polycystic ovary syndrome.","volume":"93","author":"Rossi","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"R70-10-20211004","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1210\/jc.2005-1329","article-title":"Prevalence and predictors of the metabolic syndrome in women with polycystic ovary syndrome.","volume":"91","author":"Ehrmann","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"R71-10-20211004","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1210\/jc.2005-1666","article-title":"Adolescent girls with polycystic ovary syndrome have an increased risk of the metabolic syndrome associated with increasing androgen levels independent of obesity and insulin resistance.","volume":"91","author":"Coviello","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"R72-10-20211004","doi-asserted-by":"crossref","first-page":"820","DOI":"10.3109\/09513590.2010.508851","article-title":"Metabolic syndrome in adolescents with polycystic ovary syndrome.","volume":"27","author":"Vrbikova","year":"2011","journal-title":"Gynecol Endocrinol"},{"key":"R74-10-20211004","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.jpeds.2011.04.027","article-title":"Screening for sleep-disordered breathing and excessive daytime sleepiness in adolescent girls with polycystic ovarian syndrome.","volume":"159","author":"Nandalike","year":"2011","journal-title":"J Pediatr"},{"key":"R75-10-20211004","doi-asserted-by":"crossref","first-page":"4609","DOI":"10.1210\/jc.2007-1343","article-title":"Young obese women with polycystic ovary syndrome have evidence of early coronary atherosclerosis.","volume":"92","author":"Shroff","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"R76-10-20211004","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1367\/A04-130R.1","article-title":"Overweight status of adolescent girls with polycystic ovary syndrome: body mass index as mediator of quality of life.","volume":"5","author":"Trent","year":"2005","journal-title":"Ambul Pediatr"},{"key":"R77-10-20211004","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.fertnstert.2009.08.006","article-title":"Improvement in quality-of-life questionnaire measures in obese adolescent females with polycystic ovary syndrome treated with lifestyle changes and oral contraceptives, with or without metformin.","volume":"93","author":"Harris-Glocker","year":"2010","journal-title":"Fertil Steril"},{"key":"R78-10-20211004","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1097\/AOG.0b013e318202b0a4","article-title":"Increased risk for abnormal depression scores in women with polycystic ovary syndrome: a systematic review and meta-analysis.","volume":"117","author":"Dokras","year":"2011","journal-title":"Obstet Gynecol"},{"key":"R79-10-20211004","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1542\/peds.2011-1082","article-title":"Prevalence of cardiovascular disease risk factors among US adolescents, 1999-2008.","volume":"129","author":"May","year":"2012","journal-title":"Pediatrics"},{"key":"R80-10-20211004","doi-asserted-by":"crossref","first-page":"4299","DOI":"10.1210\/jc.2008-0461","article-title":"The impact of metformin, oral contraceptives, and lifestyle modification on polycystic ovary syndrome in obese adolescent women in two randomized, placebo-controlled clinical trials.","volume":"93","author":"Hoeger","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"R81-10-20211004","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jpag.2011.01.002","article-title":"Effect of weight loss on menstrual function in adolescents with polycystic ovary syndrome.","volume":"24","author":"Ornstein","year":"2011","journal-title":"J Pediatr Adolesc Gynecol"},{"key":"R82-10-20211004","doi-asserted-by":"crossref","first-page":"3533","DOI":"10.1210\/jc.2011-1609","article-title":"Effect of lifestyle intervention on features of polycystic ovarian syndrome, metabolic syndrome, and intima-media thickness in obese adolescent girls.","volume":"96","author":"Lass","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"R83-10-20211004","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1749-6632.2000.tb06236.x","article-title":"Combined oral contraceptive treatment of adolescent girls with polycystic ovary syndrome. Lipid profile.","volume":"900","author":"Creatsas","year":"2000","journal-title":"Ann N Y Acad Sci"},{"key":"R84-10-20211004","first-page":"940","article-title":"Does obesity diminish the positive effect of oral contraceptive treatment on hyperandrogenism in women with polycystic ovarian syndrome Hum R","volume":"16","author":"Cibula","year":"2001","journal-title":"eprod"},{"key":"R85-10-20211004","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1111\/j.1365-2265.2007.03105.x","article-title":"A systematic review of commonly used medical treatments for hirsutism in women.","volume":"68","author":"Koulouri","year":"2008","journal-title":"Clin Endocrinol"},{"key":"R86-10-20211004","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1515\/JPEM.2005.18.8.761","article-title":"Randomized controlled trial evaluating response to metformin versus standard therapy in the treatment of adolescents with polycystic ovary syndrome.","volume":"18","author":"Allen","year":"2005","journal-title":"J Pediatr Endocrinolo Metab"},{"key":"R87-10-20211004","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1001\/archpedi.160.3.241","article-title":"Randomized placebo-controlled trial of metformin for adolescents with polycystic ovary syndrome.","volume":"160","author":"Bridger","year":"2006","journal-title":"Arch Pediatr Adolesc Med"},{"key":"R88-10-20211004","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s11892-002-0061-y","article-title":"Insulin resistance and polycystic ovary syndrome.","volume":"2","author":"Ehrmann","year":"2002","journal-title":"Curr Diab Rep"},{"key":"R89-10-20211004","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1093\/humrep\/17.7.1729","article-title":"Clinical, endocrine and metabolic effects of metformin added to ethinyl estradiol-cyproterone acetate in nonobese women with polycystic ovarian syndrome: a randomized controlled study.","volume":"17","author":"Elter","year":"2002","journal-title":"Hum Reprod"},{"key":"R90-10-20211004","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.fertnstert.2005.07.1306","article-title":"Effects of two forms of combined oral contraceptives on carbohydrate metabolism in adolescents with polycystic ovary syndrome.","volume":"85","author":"Mastorakos","year":"2006","journal-title":"Fertil Steril"}],"container-title":["Current Opinion in Endocrinology, Diabetes & Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/01266029-201212000-00010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T02:20:01Z","timestamp":1633314001000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01266029-201212000-00010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":88,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.1097\/med.0b013e32835a1a03","relation":{},"ISSN":["1752-296X"],"issn-type":[{"value":"1752-296X","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]}}}