{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T15:25:03Z","timestamp":1773761103449,"version":"3.50.1"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1097\/meg.0b013e32833d56d1","type":"journal-article","created":{"date-parts":[[2010,7,21]],"date-time":"2010-07-21T11:08:58Z","timestamp":1279710538000},"page":"1182-1188","source":"Crossref","is-referenced-by-count":32,"title":["Discontinuation of long-term proton pump inhibitor therapy in primary care patients: a randomized placebo-controlled trial in patients with symptom relapse"],"prefix":"10.1097","volume":"22","author":[{"given":"Christina","family":"Reimer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Bytzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-5-20210207","first-page":"2008","article-title":"Medicinal Product Statistics in Denmark.","volume":"2009","year":"10","journal-title":"last Accessed September"},{"key":"R2-5-20210207","first-page":"451","article-title":"Long-term prescribing of proton pump inhibitors in general practice","volume":"49","author":"Hungin","year":"1999","journal-title":"Br J Gen Pract"},{"key":"R3-5-20210207","first-page":"241","article-title":"How do primary care physicians use long-term acid suppressant drugs? A population-based analysis of Dutch general practices","volume":"51","author":"Hurenkamp","year":"2002","journal-title":"J Fam Pract"},{"key":"R4-5-20210207","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/j.1365-2036.2004.02120.x","article-title":"Use of anti-secretory medication: a population-based cohort study","volume":"20","author":"Lassen","year":"2004","journal-title":"Aliment Pharmacol Ther"},{"key":"R5-5-20210207","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1111\/j.1572-0241.2003.07706.x","article-title":"Chronic acid-related disorders are common and underinvestigated","volume":"98","author":"Majumdar","year":"2003","journal-title":"Am J Gastroenterol"},{"key":"R6-5-20210207","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1136\/bmj.317.7156.452","article-title":"Why are patients prescribed proton pump inhibitors? Retrospective analysis of link between morbidity and prescribing in the General Practice Research Database","volume":"317","author":"Bashford","year":"1998","journal-title":"Br Med J"},{"key":"R7-5-20210207","article-title":"NICE clinical guideline 17. Management of dyspepsia in adults in primary care","year":"2004"},{"issue":"1","key":"R8-5-20210207","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1365-2036.2005.02611.x","article-title":"Review article: the long-term use of proton-pump inhibitors","volume":"22","author":"Raghunath","year":"2005","journal-title":"Aliment Pharmacol Ther"},{"key":"R9-5-20210207","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1572-0241.2003.07186.x","article-title":"Who is using chronic acid suppression therapy and why?","volume":"98","author":"Jacobson","year":"2003","journal-title":"Am J Gastroenterol"},{"key":"R10-5-20210207","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.3748\/wjg.v12.i16.2569","article-title":"Rabeprazole test for the diagnosis of gastro-oesophageal reflux disease: results of a study in a primary care setting","volume":"12","author":"Des Varannes","year":"2006","journal-title":"World J Gastroenterol"},{"key":"R11-5-20210207","doi-asserted-by":"crossref","first-page":"518","DOI":"10.7326\/0003-4819-140-7-200404060-00011","article-title":"Short-term treatment with proton-pump inhibitors as a test for gastroesophageal reflux disease: a meta-analysis of diagnostic test characteristics","volume":"140","author":"Numans","year":"2004","journal-title":"Ann Intern Med"},{"key":"R12-5-20210207","first-page":"CD001960","article-title":"Pharmacological interventions for non-ulcer dyspepsia","volume":"4","author":"Moayyedi","year":"2004","journal-title":"Cochrane Database Syst Rev"},{"key":"R13-5-20210207","first-page":"CD001960","article-title":"Pharmacological interventions for non-ulcer dyspepsia","volume":"4","author":"Moayyedi","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"R14-5-20210207","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/j.1365-2036.2009.04092.x","article-title":"Long-term use of proton pump inhibitors in primary care patients-a cross sectional analysis of 901 patients","volume":"30","author":"Reimer","year":"2009","journal-title":"Aliment Pharmacol Ther"},{"key":"R15-5-20210207","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1111\/j.1572-0241.2003.07665.x","article-title":"Step-down from multiple- to single-dose proton pump inhibitors (PPIs): a prospective study of patients with heartburn or acid regurgitation completely relieved with PPIs","volume":"98","author":"Inadomi","year":"2003","journal-title":"Am J Gastroenterol"},{"key":"R16-5-20210207","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1111\/j.1365-2036.2006.03084.x","article-title":"Discontinuation of proton pump inhibitors in patients on long-term therapy: a double-blind, placebo-controlled trial","volume":"24","author":"Bjornsson","year":"2006","journal-title":"Aliment Pharmacol Ther"},{"key":"R18-5-20210207","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1159\/000075308","article-title":"Rising incidence of reflux oesophagitis in patients undergoing upper gastrointestinal endoscopy","volume":"68","author":"Loffeld","year":"2003","journal-title":"Digestion"},{"key":"R19-5-20210207","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1053\/j.gastro.2009.03.058","article-title":"Proton pump inhibitor therapy induces acid-related symptoms in healthy volunteers after withdrawal of therapy","volume":"1","author":"Reimer","year":"2009","journal-title":"Gastroenterology"},{"key":"R21-5-20210207","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1111\/j.1365-2036.2005.02413.x","article-title":"Long-term treatment of gastro-oesophageal reflux disease patients with frequent symptomatic relapses using rabeprazole: on-demand treatment compared with continuous treatment","volume":"21","author":"Bour","year":"2005","journal-title":"Aliment Pharmacol Ther"},{"key":"R22-5-20210207","first-page":"703","article-title":"Proton pump inhibitors: perspectives of patients and their GPs","volume":"51","author":"Grime","year":"2001","journal-title":"Br J Gen Pract"},{"key":"R23-5-20210207","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1001\/jama.294.23.2989","article-title":"Use of gastric acid-suppressive agents and the risk of community-acquired Clostridium difficile-associated disease","volume":"294","author":"Dial","year":"2005","journal-title":"JAMA"},{"key":"R24-5-20210207","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1111\/j.1572-0241.2007.01275.x","article-title":"Systematic review of the risk of enteric infection in patients taking acid suppression","volume":"102","author":"Leonard","year":"2007","journal-title":"Am J Gastroenterol"},{"key":"R25-5-20210207","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1046\/j.1365-2036.2003.01744.x","article-title":"Gastric acid-suppressive therapy and community-acquired respiratory infections","volume":"18","author":"Laheij","year":"2003","journal-title":"Aliment Pharmacol Ther"},{"key":"R26-5-20210207","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1001\/jama.292.16.1955","article-title":"Risk of community-acquired pneumonia and use of gastric acid-suppressive drugs","volume":"292","author":"Laheij","year":"2004","journal-title":"JAMA"},{"key":"R27-5-20210207","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s00223-006-0021-7","article-title":"Proton pump inhibitors, histamine H2 receptor antagonists, and other antacid medications and the risk of fracture","volume":"79","author":"Vestergaard","year":"2006","journal-title":"Calcif Tissue Int"},{"key":"R28-5-20210207","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1056\/NEJMc066308","article-title":"Proton-pump inhibitors and hypomagnesemic hypoparathyroidism","volume":"355","author":"Epstein","year":"2006","journal-title":"N Engl J Med"},{"key":"R29-5-20210207","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1345\/aph.1C037","article-title":"Ambulatory care increased vitamin B12 requirement associated with chronic acid suppression therapy","volume":"37","author":"Force","year":"2003","journal-title":"Ann Pharmacother"}],"container-title":["European Journal of Gastroenterology &amp; Hepatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.lww.com\/00042737-201010000-00005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,10]],"date-time":"2021-04-10T06:34:49Z","timestamp":1618036489000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00042737-201010000-00005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":27,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1097\/meg.0b013e32833d56d1","relation":{},"ISSN":["0954-691X"],"issn-type":[{"value":"0954-691X","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10]]}}}