{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T04:03:48Z","timestamp":1695009828203},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:p>To report the experience of a large tertiary care pediatric center during a period of increasing <jats:italic toggle=\"yes\">Streptococcus pneumoniae<\/jats:italic> antimicrobial resistance before the introduction of pneumococcal vaccine in Israel. Retrospective chart review of children diagnosed acute mastoiditis (AM) between January 1997 and December 2007. The children were divided into 4 age groups (6\u201311, 12\u201323, 24\u201335, and 36\u201340 months), and each group was compared with the others. A total of 198 AM episodes were recorded during the 10-year study period. The most prevalent pathogen was <jats:italic toggle=\"yes\">S. pneumonia<\/jats:italic>, with a very low (15%) penicillin resistance rate (minimal inhibitory concentration \u2265 2). Complications were more prevalent in the 12- to 23-month age group. The number of AM cases increased during the study period. Penicillin resistance did not play an important role in determining the morbidity before the introduction of pneumococcal conjugate vaccine.<\/jats:p>","DOI":"10.1097\/mjt.0000000000000097","type":"journal-article","created":{"date-parts":[[2014,10,4]],"date-time":"2014-10-04T14:58:36Z","timestamp":1412434716000},"page":"e1371-e1374","source":"Crossref","is-referenced-by-count":3,"title":["Acute Mastoiditis Before Pneumococcal Vaccination: The Experience of a Large Tertiary Care Pediatric Hospital"],"prefix":"10.1097","volume":"23","author":[{"given":"Miguel","family":"Glatstein","sequence":"first","affiliation":[{"name":"Division of Pediatric Emergency Medicine, Department of Pediatrics, Dana-Dwek Children Hospital, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv, Israel;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Morag","sequence":"additional","affiliation":[{"name":"Divisions of Pediatric Department, Dana-Dwek Children Hospital, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv, Israel;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis","family":"Scolnik","sequence":"additional","affiliation":[{"name":"Divisions of Pediatric Emergency Medicine and Clinical Pharmacology and Toxicology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arik","family":"Alper","sequence":"additional","affiliation":[{"name":"Divisions of Pediatric Department, Dana-Dwek Children Hospital, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv, Israel;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shimon","family":"Reif","sequence":"additional","affiliation":[{"name":"Divisions of Pediatric Department, Dana-Dwek Children Hospital, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv, Israel;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Galia","family":"Grisaru-Soen","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, Department of Pediatrics, Dana-Dwek Children's Hospital Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-20230917","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1177\/000348940911800806","article-title":"Acute mastoiditis in children: is computed tomography always necessary?","volume":"118","author":"Tamir","year":"2009","journal-title":"Ann Otol Rhinol Laryngol."},{"key":"R2-20230917","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.amjoto.2009.06.003","article-title":"Shifting trends: mastoiditis from a surgical to a medical disease","volume":"31","author":"Tamir","year":"2010","journal-title":"Am J Otolaryngol."},{"key":"R3-20230917","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.ijporl.2007.02.014","article-title":"Acute mastoiditis: increase in the incidence and complications","volume":"71","author":"Benito","year":"2007","journal-title":"Int J Pediatr Otorhinolaryngol."},{"key":"R4-20230917","first-page":"7","article-title":"Should children with acute otitis media routinely be treated with antibiotics? 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