{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T23:02:19Z","timestamp":1790118139502,"version":"4.0.1"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1097\/mjt.0b013e318250f829","type":"journal-article","created":{"date-parts":[[2013,1,9]],"date-time":"2013-01-09T02:09:01Z","timestamp":1357697341000},"page":"37-40","source":"Crossref","is-referenced-by-count":17,"title":["Direct Comparison of 20-Hour IV, 36-Hour Oral, and 72-Hour Oral Acetylcysteine for Treatment of Acute Acetaminophen Poisoning"],"prefix":"10.1097","volume":"20","author":[{"given":"Kelly","family":"Williamson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Wahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark B.","family":"Mycyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-7-20210202","doi-asserted-by":"crossref","first-page":"177","DOI":"10.2165\/00019053-199508030-00001","article-title":"The human and economic cost of paracetamol (acetaminophen) overdose.","volume":"8","author":"Bond","year":"1995","journal-title":"Pharmacoeconomics"},{"key":"R2-7-20210202","doi-asserted-by":"crossref","first-page":"910","DOI":"10.3109\/15563650.2011.635149","article-title":". 2010 annual report of the American Association of Poison Control Centers National Poison Data System (NPDS): 28th annual report.","volume":"49","author":"Bronstein","year":"2011","journal-title":"Clin Toxicol"},{"key":"R3-7-20210202","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/hep.24060","article-title":". and the Acute Liver Failure Study Group. Unrecognized acetaminophen toxicity as a cause of indeterminate acute liver failure.","volume":"53","author":"Khandelwal","year":"2011","journal-title":"Hepatology"},{"key":"R4-7-20210202","doi-asserted-by":"crossref","first-page":"149","DOI":"10.2165\/11595890-000000000-00000","article-title":"Trends in hepatic injury associated with unintentional overdose of paracetamol (acetaminophen) in products with and without opioid: an analysis using the national poison data system of the American Association of Poison control centers, 2000-7.","volume":"35","author":"Bond","year":"2012","journal-title":"Drug Saf"},{"key":"R5-7-20210202","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1136\/bmj.2.6198.1097","article-title":". Intravenous N-acetylcysteine: the treatment of choice for paracetamol poisoning.","volume":"2","author":"Prescott","year":"1979","journal-title":"Br Med J"},{"key":"R6-7-20210202","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1056\/NEJM198812153192401","article-title":". Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976-1985).","volume":"319","author":"Smilkstein","year":"1988","journal-title":"N Engl J Med"},{"key":"R7-7-20210202","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1056\/NEJMct0708278","article-title":"Acetylcysteine for acetaminophen poisoning.","volume":"359","author":"Heard","year":"2008","journal-title":"N Engl J Med"},{"key":"R8-7-20210202","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1345\/aph.1K680","article-title":". Acetaminophen overdose with altered acetaminophen pharmacokinetics and hepatotoxicity associated with premature cessation of intravenous N-acetylcysteine therapy.","volume":"42","author":"Smith","year":"2008","journal-title":"Ann Pharmacother"},{"key":"R9-7-20210202","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1553-2712.2008.00296.x","article-title":"Hepatotoxicity despite early administration of intravenous N-acetylcysteine for acute acetaminophen overdose.","volume":"16","author":"Doyon","year":"2009","journal-title":"Acad Emerg Med"},{"key":"R10-7-20210202","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.annemergmed.2008.10.001","article-title":"Development of hepatic failure despite use of intravenous acetylcysteine after a massive ingestion of acetaminophen and diphenhydramine.","volume":"54","author":"Schwartz","year":"2009","journal-title":"Ann Emerg Med"},{"key":"R11-7-20210202","doi-asserted-by":"crossref","first-page":"e1077","DOI":"10.1542\/peds.2010-2521","article-title":". Hepatic failure despite early acetylcysteine following large acetaminophen-diphenhydramine overdose.","volume":"127","author":"Wang","year":"2011","journal-title":"Pediatrics"},{"key":"R12-7-20210202","first-page":"759","article-title":"OConnell DL, et al..","volume":"37","author":"Buckley","year":"1999","journal-title":"Oral or intravenous N-acetylcysteine: which is the treatment of choice for acetaminophen poisoning Clin Toxicol"},{"key":"R13-7-20210202","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.2146\/ajhp060050","article-title":"Comparison of oral and IV acetylcysteine in the treatment of acetaminophen poisoning.","volume":"63","author":"Kanter","year":"2006","journal-title":"Am J Health-Syst Pharm"},{"key":"R14-7-20210202","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0196-0644(00)70055-2","article-title":". Shorter duration of oral N-acetylcysteine therapy for acute acetaminophen overdose.","volume":"35","author":"Woo","year":"2000","journal-title":"Ann Emerg Med"},{"key":"R15-7-20210202","first-page":"1052","article-title":"Acetaminophen intoxication and length of treatment: how long is long enough Pharmacotherapy.","volume":"23","author":"Kociancic","year":"2003","journal-title":""},{"key":"R16-7-20210202","first-page":"305","article-title":"Chart reviews in emergency medicine research: where are the methods Ann Emerg Med.","volume":"27","author":"Gilbert","year":"1996","journal-title":""},{"key":"R17-7-20210202","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/0016-5085(89)90081-4","article-title":". Early indicators of prognosis in fulminant hepatic failure.","volume":"97","author":"OGrady","year":"1989","journal-title":"Gastroenterology"},{"key":"R18-7-20210202","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.annemergmed.2009.05.010","article-title":". Comparison of the 20-hour intravenous and 72-hour oral acetylcysteine protocols for the treatment of acute acetaminophen poisoning.","volume":"54","author":"Yarema","year":"2009","journal-title":"Ann Emerg Med"}],"container-title":["American Journal of Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.lww.com\/00045391-201301000-00007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,10]],"date-time":"2021-04-10T06:42:46Z","timestamp":1618036966000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00045391-201301000-00007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1097\/mjt.0b013e318250f829","relation":{},"ISSN":["1075-2765"],"issn-type":[{"value":"1075-2765","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]}}}