{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T04:30:33Z","timestamp":1773721833914,"version":"3.50.1"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:p>Gout, an extremely painful arthritis with relapsing inflammatory attacks, is a common inflammatory joint disease in adults. We examined the therapeutic effect of ketotifen, a mast cell stabilizer, on monosodium urate (MSU) crystal-induced acute inflammation. Eight-week-old male Wistar rats were injected with MSU crystals (5 mg per rat) into air pouch. Ketotifen (0, 0.1, 03, and 1 mg\/kg) was given 1 hour before MSU crystal injection. Lavage histamine, leukocyte counts, mast cell counts, nitric oxide, and proinflammatory mediator levels were assessed 12 hours after MSU injection. Ketotifen significantly inhibited MSU-induced mast cell activation and histamine concentration in air pouch lavage. Ketotifen dose-dependently inhibited MSU-initiated leukocyte infiltration into the air pouch. Furthermore, ketotifen significantly decreased proinflammatory mediators, including nitric oxide, interleukin-1\u03b2, and interleukin-6, production in MSU-treated rats. Ketotifen may attenuate MSU-induced acute inflammation by inhibiting mast cell activation and leukocyte infiltration in rats. Furthermore, ketotifen has the potential to be a new approach in managing patients with gouty inflammation in the future.<\/jats:p>","DOI":"10.1097\/mjt.0b013e31829ea238","type":"journal-article","created":{"date-parts":[[2013,7,24]],"date-time":"2013-07-24T21:32:37Z","timestamp":1374701557000},"page":"e1009-e1015","source":"Crossref","is-referenced-by-count":17,"title":["Mast Cell Stabilizer Ketotifen Inhibits Gouty Inflammation in Rats"],"prefix":"10.1097","volume":"23","author":[{"given":"Dur-Zong","family":"Hsu","sequence":"first","affiliation":[{"name":"Departments of Environmental and Occupational Health, National Cheng Kung University Medical College, Tainan, Taiwan; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei-Yi","family":"Chu","sequence":"additional","affiliation":[{"name":"Departments of Environmental and Occupational Health, National Cheng Kung University Medical College, Tainan, Taiwan; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si-Jin","family":"Chen","sequence":"additional","affiliation":[{"name":"Departments of Environmental and Occupational Health, National Cheng Kung University Medical College, Tainan, Taiwan; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Yie","family":"Liu","sequence":"additional","affiliation":[{"name":"Departments of Environmental and Occupational Health, National Cheng Kung University Medical College, Tainan, Taiwan; and"},{"name":"Sustainable Environment Research Centre, National Cheng Kung University, Tainan, Taiwan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-20230917","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1001\/archinte.1960.03820030088013","article-title":"Some aspects of the epidemiology of gout. 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