{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:38:15Z","timestamp":1760981895791},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,1,2]],"date-time":"2009-01-02T00:00:00Z","timestamp":1230854400000},"content-version":"vor","delay-in-days":673,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objective:<\/jats:bold> To evaluate the effects of the ciprofloxacin\u2010dexamethasone (CDX) combination ototopical treatment after myringotomy on tympanic membrane (TM) healing in ears with eustachian tube obstruction (ETO) and unobstructed ears.<\/jats:p><jats:p><jats:bold>Study Design:<\/jats:bold> Prospective, randomized, masked, controlled.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> ETO was created in the left ear of 30 rats to induce a model of otitis media with effusion (OME). After 3 weeks, bilateral myringotomy was performed (day 0). Animals were randomized into three groups to receive no treatment or bilateral once daily ototopical treatment with balanced salt solution (BSS, vehicle) or CDX for 13 days. Bilateral otomicroscopy was performed on days 7, 14, and 28. On day 14, five randomly selected animals per group were humanely euthanized and the TM harvested for histology. Three additional rats provided normal negative control ears for histologic comparisons.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> On day 14, TM perforation healing rates were 100% in all ears of untreated and BSS\u2010treated animals, 89% (8\/9) in CDX\u2010treated obstructed ears, and 30% (3\/10) in CDX\u2010treated unobstructed ears (<jats:italic>P<\/jats:italic> &lt; .05 vs. BSS). On day 28, 100% (5\/5) of the CDX\u2010treated unobstructed ears and 80% (4\/5) of the CDX\u2010treated obstructed ears were healed. Histology showed initial TM thickening postmyringotomy in all ears but no significant qualitative differences between groups on day 28.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Myringotomy healing was transiently modulated by treatment with CDX but proceeded normally after CDX discontinuation. This early modulation might enhance middle ear drainage and middle ear concentrations of CDX when tympanostomy tube surgery is performed in patients with active OME and ETO, thus potentially reducing otorrhea and preventing or treating infection. It would not be expected to increase the risk of premature tube extrusion or adversely affect normal healing of the TM after usual spontaneous extrusion.<\/jats:p>","DOI":"10.1097\/mlg.0b013e31802f3c86","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T15:26:07Z","timestamp":1172762767000},"page":"522-528","source":"Crossref","is-referenced-by-count":18,"title":["Effects of Ciprofloxacin\u2010Dexamethasone on Myringotomy Wound Healing"],"prefix":"10.1002","volume":"117","author":[{"given":"Patricia A.","family":"Hebda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sancak","family":"Yuksel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph E.","family":"Dohar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,2]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(05)70513-7"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949410300909"},{"key":"e_1_2_7_4_2","first-page":"416","article-title":"The effect of topical ciprofloxacin on postoperative otorrhea after tympanostomy tube insertion.","volume":"20","author":"Zipfel TE","year":"1999","journal-title":"Am J Otol"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949410300110"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.126.2.165"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200312000-00011"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.7.2229"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.135.11.1265"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200209000-00024"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(01)00640-1"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-363706-2.50010-6"},{"key":"e_1_2_7_13_2","first-page":"277","article-title":"Steroids, retinoids, and wound healing.","volume":"11","author":"Anstead GM","year":"1998","journal-title":"Adv Wound Care"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.131.4.330"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199609000-00005"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199801000-00019"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1097%2FMLG.0b013e31802f3c86","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/MLG.0b013e31802f3c86","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T20:24:10Z","timestamp":1696883050000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/MLG.0b013e31802f3c86"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["10.1097\/MLG.0b013e31802f3c86"],"URL":"https:\/\/doi.org\/10.1097\/mlg.0b013e31802f3c86","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,3]]}}}