{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:07:21Z","timestamp":1793383641313,"version":"4.5.0"},"reference-count":256,"publisher":"Wiley","issue":"S114","license":[{"start":{"date-parts":[[2009,1,2]],"date-time":"2009-01-02T00:00:00Z","timestamp":1230854400000},"content-version":"vor","delay-in-days":581,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objectives\/Hypothesis<\/jats:bold>\n                    : Laryngomalacia is an enigmatic disease in which laryngeal tone is weak, resulting in dynamic prolapse of tissue into the larynx. Sensorimotor integrative function of the brainstem and peripheral reflexes are responsible for laryngeal tone and airway patency. The goal of this study was to elucidate the etiology of decreased laryngeal tone through evaluating the sensorimotor integrative function of the larynx. The secondary goal was to evaluate factors and medical comorbidities that contribute to the wide spectrum of symptoms and outcomes.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Study Design<\/jats:bold>\n                    : Prospective and retrospective collection of evaluative data on infants with congenital laryngomalacia at two tertiary care pediatric referral centers.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods<\/jats:bold>\n                    : Two hundred one infants with laryngomalacia were divided into three groups on the basis of disease severity (mild, moderate, severe). Patients were followed prospectively every 8 to 12 weeks until symptom resolution or loss to follow\u2010up. Sensorimotor integrative function of the larynx was evaluated in 134 infants by laryngopharyngeal sensory testing (LPST) of the laryngeal adductor reflex (LAR) by delivering a duration\u2010 (50 ms) and intensity\u2010 (2.5\u201310 mm Hg) controlled air pulse to the aryepiglottic fold to induce the LAR. Medical records were retrospectively reviewed for medical comorbidities.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    : The initial LPST was higher (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; .001) in infants with moderate (6.8 mm Hg) and severe disease (7.4 mm Hg) compared with those with mild disease (4.1 mm Hg). At 1, 3, and 6 months, infants with moderate and severe disease continued to have a higher LPST compared with those with mild disease. At 9 months, the LPST decreased in all subjects (3.1\u20133.5 mm Hg,\n                    <jats:italic>P<\/jats:italic>\n                    = .14), which also correlated with symptom resolution. Neurologic, genetic, and cardiac diseases were more common in infants with severe disease (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; .001). Gastroesophageal reflux disease (GERD) and feeding problems more common in those with moderate and severe disease (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; .001). Apgar scores were lower in those with severe disease (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; .001). Most symptoms resolved within 12 months of presentation. Those with GERD benefited from treatment. Supraglottoplasty resulted in few complications. Multiple comorbidities (&gt;3) influenced the need for tracheotomy.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions<\/jats:bold>\n                    : Laryngeal tone and sensorimotor integrative function of the larynx is altered. The degree of alteration correlated with disease severity, indicating that factors that alter the peripheral and central reflexes of the LAR have a role in the etiology of signs and symptoms of laryngomalacia. GERD, neurologic disease, and low Apgar scores influenced disease severity and clinical course, explaining the spectrum of disease symptoms and outcomes. Sensorimotor integrative function improved as symptoms resolved.\n                  <\/jats:p>","DOI":"10.1097\/mlg.0b013e31804a5750","type":"journal-article","created":{"date-parts":[[2007,5,18]],"date-time":"2007-05-18T17:53:25Z","timestamp":1179510805000},"page":"1-33","source":"Crossref","is-referenced-by-count":258,"title":["Abnormal Sensorimotor Integrative Function of the Larynx in Congenital Laryngomalacia: A New Theory of Etiology"],"prefix":"10.1002","volume":"117","author":[{"given":"Dana Mara","family":"Thompson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,2]]},"reference":[{"key":"e_1_2_10_1_2_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198902000-00004"},{"key":"e_1_2_10_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03009914"},{"key":"e_1_2_10_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(98)00111-6"},{"key":"e_1_2_10_1_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199911000-00009"},{"key":"e_1_2_10_1_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348945406300302"},{"key":"e_1_2_10_1_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348946707600402"},{"key":"e_1_2_10_1_8_2","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0030-6665(20)33139-X","article-title":"Congenital abnormalities of the infant larynx.","volume":"3","author":"Ferguson CF","year":"1970","journal-title":"Otolaryngol Clin North Am"},{"key":"e_1_2_10_1_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348948008900502"},{"key":"e_1_2_10_1_10_2","first-page":"363","article-title":"Anomalies laryngies du noujveau\u2010ne apropos de 687 observations.","volume":"101","author":"Narcy P","year":"1984","journal-title":"Ann Otolaryngol Chir Cervicofac"},{"key":"e_1_2_10_1_11_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199003000-00013"},{"key":"e_1_2_10_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(97)00151-1"},{"key":"e_1_2_10_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(99)70327-X"},{"key":"e_1_2_10_1_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00168491"},{"key":"e_1_2_10_1_15_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199510000-00018"},{"key":"e_1_2_10_1_16_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.119.2.409"},{"key":"e_1_2_10_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(99)70408-0"},{"key":"e_1_2_10_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(01)00861-0"},{"key":"e_1_2_10_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.19502308152"},{"key":"e_1_2_10_1_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348940010900402"},{"key":"e_1_2_10_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0196-0709(91)90123-W"},{"key":"e_1_2_10_1_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1984.00800340058017"},{"key":"e_1_2_10_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(85)80027-6"},{"key":"e_1_2_10_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5876(87)90005-X"},{"key":"e_1_2_10_1_25_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348948709600118"},{"key":"e_1_2_10_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)83325-6"},{"key":"e_1_2_10_1_27_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949009900807"},{"key":"e_1_2_10_1_28_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100118158"},{"key":"e_1_2_10_1_29_2","doi-asserted-by":"publisher","DOI":"10.1258\/0022215011906966"},{"key":"e_1_2_10_1_30_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199403000-00001"},{"key":"e_1_2_10_1_31_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.129.10.1077"},{"key":"e_1_2_10_1_32_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348948409300502"},{"key":"e_1_2_10_1_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200302000-00012"},{"key":"e_1_2_10_1_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.10164"},{"key":"e_1_2_10_1_35_2","first-page":"495","article-title":"Surgical risk factors in Larsen's syndrome.","volume":"66","author":"Karakas K","year":"2000","journal-title":"Acta Orthop Belg"},{"key":"e_1_2_10_1_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(199711)24:5<364::AID-PPUL9>3.0.CO;2-I"},{"key":"e_1_2_10_1_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(96)01454-1"},{"key":"e_1_2_10_1_38_2","first-page":"896","article-title":"Hypoxia and hypercapnia in infants with mild laryngomalacia.","volume":"142","author":"McCray PB","year":"1988","journal-title":"Am J Dis Child"},{"key":"e_1_2_10_1_39_2","first-page":"728","article-title":"Cardiac failure complicating laryngomalacia in a newborn infant (letter) [in French].","volume":"41","author":"Voisin M","year":"1984","journal-title":"Arch Fr Pediatr"},{"key":"e_1_2_10_1_40_2","first-page":"484","volume-title":"Traiate Clinique et Pratique des Maladies des Enfants","author":"Barthez E","year":"1843"},{"key":"e_1_2_10_1_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)31065-0"},{"key":"e_1_2_10_1_42_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-193001000-00008"},{"key":"e_1_2_10_1_43_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.52.3.215"},{"key":"e_1_2_10_1_44_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1953.00710040265002"},{"key":"e_1_2_10_1_45_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197601000-00018"},{"key":"e_1_2_10_1_46_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1944.00680010418003"},{"key":"e_1_2_10_1_47_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.2083.1561-a"},{"key":"e_1_2_10_1_48_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.28.142.423"},{"key":"e_1_2_10_1_49_2","first-page":"360","article-title":"Intellectual impairment in congenital laryngeal stridor.","volume":"113","author":"Benians RC","year":"1964","journal-title":"Guy's Hosp Report"},{"key":"e_1_2_10_1_50_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949510400603"},{"key":"e_1_2_10_1_51_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949710601101"},{"key":"e_1_2_10_1_52_2","first-page":"896","article-title":"Acquired flaccid larynx. A case report supporting the neurologic theory of laryngomalacia.","volume":"131","author":"Archer SM","year":"1992","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"e_1_2_10_1_53_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949210100405"},{"key":"e_1_2_10_1_54_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198806000-00016"},{"key":"e_1_2_10_1_55_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199004000-00008"},{"key":"e_1_2_10_1_56_2","doi-asserted-by":"publisher","DOI":"10.1159\/000241157"},{"key":"e_1_2_10_1_57_2","first-page":"R30","article-title":"Properties of the laryngeal chemoreflex in neonatal piglets.","volume":"233","author":"Lee JC","year":"1977","journal-title":"Am J Physiol"},{"key":"e_1_2_10_1_58_2","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1542\/peds.55.5.640","article-title":"Laryngeal chemosensitivity: a possible mechanism for sudden infant death.","volume":"55","author":"Downing SE","year":"1975","journal-title":"Pediatrics"},{"key":"e_1_2_10_1_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(78)90051-1"},{"key":"e_1_2_10_1_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(75)90235-6"},{"key":"e_1_2_10_1_61_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949310201007"},{"key":"e_1_2_10_1_62_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949910800802"},{"key":"e_1_2_10_1_63_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949710600201"},{"key":"e_1_2_10_1_64_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949610500202"},{"key":"e_1_2_10_1_65_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949810700503"},{"key":"e_1_2_10_1_66_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348940010901002"},{"key":"e_1_2_10_1_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(03)00217-1"},{"key":"e_1_2_10_1_68_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348940511400402"},{"key":"e_1_2_10_1_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59989770268-7"},{"key":"e_1_2_10_1_70_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949410301001"},{"key":"e_1_2_10_1_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(97)00327-6"},{"key":"e_1_2_10_1_72_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000225942.33102.9b"},{"key":"e_1_2_10_1_73_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348940010901103"},{"issue":"1","key":"e_1_2_10_1_74_2","first-page":"S23","article-title":"Laryngopharyngeal manifestations of reflux: diagnosis and therapy.","volume":"14","author":"Close LG","year":"2002","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"e_1_2_10_1_75_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.1.9811043"},{"key":"e_1_2_10_1_76_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2001.280.2.G191"},{"key":"e_1_2_10_1_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)00343-5"},{"key":"e_1_2_10_1_78_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/81.3.364"},{"key":"e_1_2_10_1_79_2","first-page":"198","article-title":"An anatomical analysis of cortico\u2010bulbar connexions to the pons and lower brain stem in the cat.","volume":"92","author":"Kuypers HG","year":"1958","journal-title":"J Anat"},{"key":"e_1_2_10_1_80_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000150695.15883.a4"},{"key":"e_1_2_10_1_81_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348940311200401"},{"key":"e_1_2_10_1_82_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348940111000502"},{"key":"e_1_2_10_1_83_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.2.929"},{"key":"e_1_2_10_1_84_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.52.3.215"},{"key":"e_1_2_10_1_85_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.127.6.694"},{"key":"e_1_2_10_1_86_2","first-page":"1618","article-title":"The apgar value of the newborn and its prognostic value for the course of the neonatal period.","volume":"98","author":"Issel EP","year":"1976","journal-title":"Zentralbl Gynakol"},{"key":"e_1_2_10_1_87_2","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1542\/peds.68.1.36","article-title":"Apgar scores as predictors of chronic neurologic disability.","volume":"68","author":"Nelson KB","year":"1981","journal-title":"Pediatrics"},{"key":"e_1_2_10_1_88_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1979.tb04980.x"},{"key":"e_1_2_10_1_89_2","first-page":"29","article-title":"Epiglottoplasty in the treatment of laryngomalacia.","volume":"22","author":"Zeitouni A","year":"1993","journal-title":"J Otolaryngol"},{"key":"e_1_2_10_1_90_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.56.5.345"},{"key":"e_1_2_10_1_91_2","first-page":"19","article-title":"larynx from an infant with a peculiar form of obstructed respiration.","volume":"34","author":"Lees D","year":"1883","journal-title":"Trans Pathol Soc Lond"},{"key":"e_1_2_10_1_92_2","first-page":"490","article-title":"Un cas de respiration stridoreuse des nouveau\u2010nes avec autopsie.","volume":"27","author":"Variot G","year":"1898","journal-title":"Soc Med Hop"},{"key":"e_1_2_10_1_93_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-192201000-00003"},{"key":"e_1_2_10_1_94_2","first-page":"223","article-title":"Diagnostik and therapie des stridor congenitus.","volume":"21","author":"Hasslinger F","year":"1928","journal-title":"Z Hals Nasen Ohrenheilkd"},{"key":"e_1_2_10_1_95_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200100002-00001"},{"key":"e_1_2_10_1_96_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1999.00499.x"},{"key":"e_1_2_10_1_97_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70010-1"},{"key":"e_1_2_10_1_98_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.10156"},{"key":"e_1_2_10_2_2_2","volume-title":"Diseases and Injuries of the Larynx","author":"Jackson C","year":"1942"},{"key":"e_1_2_10_2_3_2","first-page":"484","volume-title":"Traiate clinique et pratique des maladies des enfants","author":"Barthez E","year":"1843"},{"key":"e_1_2_10_2_4_2","first-page":"19","article-title":"larynx from an infant with a peculiar form of obstructed respiration.","volume":"34","author":"Lees D","year":"1883","journal-title":"Trans Pathol Soc Lond"},{"key":"e_1_2_10_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)31065-0"},{"key":"e_1_2_10_2_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.2083.1561-a"},{"key":"e_1_2_10_2_7_2","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0030-6665(20)33139-X","article-title":"Congenital abnormalities of the infant larynx.","volume":"3","author":"Ferguson CF","year":"1970","journal-title":"Otolaryngol Clin North Am"},{"key":"e_1_2_10_2_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1944.00680010418003"},{"key":"e_1_2_10_2_9_2","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1542\/peds.27.3.477","article-title":"Congenital laryngeal stridor and speculations regarding its origin.","volume":"27","author":"Schwartz A","year":"1961","journal-title":"Pediatrics"},{"key":"e_1_2_10_2_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348945406300302"},{"key":"e_1_2_10_2_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348946707600402"},{"key":"e_1_2_10_2_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348948008900502"},{"key":"e_1_2_10_2_13_2","first-page":"363","article-title":"Anomalies laryngies du noujveau\u2010ne apropos de 687 observations.","volume":"101","author":"Narcy P","year":"1984","journal-title":"Ann Otolaryngol Chir Cervicofac"},{"key":"e_1_2_10_2_14_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199003000-00013"},{"key":"e_1_2_10_2_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.28.142.423"},{"key":"e_1_2_10_2_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199911000-00009"},{"key":"e_1_2_10_2_17_2","doi-asserted-by":"publisher","DOI":"10.1258\/0022215011906966"},{"key":"e_1_2_10_2_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949009900807"},{"key":"e_1_2_10_2_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.127.6.694"},{"key":"e_1_2_10_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0196-0709(91)90123-W"},{"key":"e_1_2_10_2_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.52.3.215"},{"key":"e_1_2_10_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(97)00151-1"},{"key":"e_1_2_10_2_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348940010900402"},{"key":"e_1_2_10_2_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.56.5.345"},{"key":"e_1_2_10_2_25_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100057455"},{"key":"e_1_2_10_2_26_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-192201000-00003"},{"key":"e_1_2_10_2_27_2","doi-asserted-by":"publisher","DOI":"10.1177\/000992287701600104"},{"key":"e_1_2_10_2_28_2","first-page":"317","article-title":"Airway obstruction in the pediatric patient.","volume":"9","author":"Rowe LD","year":"1982","journal-title":"Prim Care"},{"key":"e_1_2_10_2_29_2","first-page":"490","article-title":"Un cas de respiration stridoreuse des nouveau\u2010nes avec autopsie.","volume":"27","author":"Variot G","year":"1898","journal-title":"Soc Med Hop"},{"key":"e_1_2_10_2_30_2","first-page":"223","article-title":"Diagnostik and therapie des stridor congenitus.","volume":"21","author":"Hasslinger F","year":"1928","journal-title":"Z Hals Nasen Ohrenheilkd"},{"key":"e_1_2_10_2_31_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.52.3.215"},{"key":"e_1_2_10_2_32_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348948709600118"},{"key":"e_1_2_10_2_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03009914"},{"key":"e_1_2_10_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(85)80027-6"},{"key":"e_1_2_10_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(98)00111-6"},{"key":"e_1_2_10_2_36_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198902000-00004"},{"key":"e_1_2_10_2_37_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199510000-00018"},{"key":"e_1_2_10_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5876(91)90060-O"},{"key":"e_1_2_10_2_39_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348948409300502"},{"key":"e_1_2_10_2_40_2","first-page":"363","article-title":"Laryngeal anomalies in newborn infants. Apropos of 687 cases.","volume":"101","author":"Narcy P","year":"1984","journal-title":"Ann Otolaryngol Chir Cervicofac"},{"key":"e_1_2_10_2_41_2","first-page":"985","article-title":"Laser supraarytenoidectomy for laryngomalacia with apnea.","volume":"42","author":"Katin LI","year":"1990","journal-title":"Trans Pa Acad Ophthalmol Otolaryngol"},{"key":"e_1_2_10_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5876(93)90059-C"},{"key":"e_1_2_10_2_43_2","first-page":"29","article-title":"Epiglottoplasty in the treatment of laryngomalacia.","volume":"22","author":"Zeitouni A","year":"1993","journal-title":"J Otolaryngol"},{"key":"e_1_2_10_2_44_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199403000-00001"},{"key":"e_1_2_10_2_45_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1995.01890120011002"},{"key":"e_1_2_10_2_46_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.129.10.1077"},{"key":"e_1_2_10_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(01)00515-8"},{"key":"e_1_2_10_2_48_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348948709600118"},{"key":"e_1_2_10_2_49_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1995.01890120011002"},{"key":"e_1_2_10_2_50_2","doi-asserted-by":"crossref","unstructured":"HolingerPH JohnsonKC.The infant with respiratory stridor. Pediatr Clin North Am1955:403\u2013411.","DOI":"10.1016\/S0031-3955(16)30220-6"},{"key":"e_1_2_10_2_51_2","doi-asserted-by":"crossref","unstructured":"AtkinsJP.Laryngeal problems of infancy and childhood. Pediatr Clin North Am1962:1125\u20131135.","DOI":"10.1016\/S0031-3955(16)31344-X"},{"key":"e_1_2_10_2_52_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1984.00800340058017"},{"key":"e_1_2_10_2_53_2","first-page":"728","article-title":"Cardiac failure complicating laryngomalacia in a newborn infant (letter) [in French].","volume":"41","author":"Voisin M","year":"1984","journal-title":"Arch Fr Pediatr"},{"key":"e_1_2_10_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(00)00461-4"},{"key":"e_1_2_10_2_55_2","doi-asserted-by":"publisher","DOI":"10.1177\/089033449401000316"},{"key":"e_1_2_10_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(99)70408-0"},{"key":"e_1_2_10_2_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(01)00861-0"},{"key":"e_1_2_10_2_58_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-003-0027-5"},{"key":"e_1_2_10_2_59_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.19502308152"},{"key":"e_1_2_10_2_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(99)90562-6"},{"key":"e_1_2_10_2_61_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.7.2104085"},{"key":"e_1_2_10_2_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(96)01454-1"},{"key":"e_1_2_10_2_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(00)00439-0"},{"key":"e_1_2_10_2_64_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00270814"},{"key":"e_1_2_10_2_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5876(87)90005-X"},{"key":"e_1_2_10_2_66_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.10156"},{"key":"e_1_2_10_2_67_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.10332"},{"key":"e_1_2_10_2_68_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.129.6.642"},{"key":"e_1_2_10_2_69_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200302000-00012"},{"key":"e_1_2_10_2_70_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(199711)24:5<364::AID-PPUL9>3.0.CO;2-I"},{"key":"e_1_2_10_2_71_2","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s00405-002-0477-7","article-title":"Epiglottopexy for the treatment of severe laryngomalacia.","volume":"259","author":"Werner JA","year":"2002","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"e_1_2_10_2_72_2","doi-asserted-by":"publisher","DOI":"10.1053\/ajot.2000.16166"},{"key":"e_1_2_10_2_73_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1989.01860290084019"},{"key":"e_1_2_10_2_74_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348948109000401"},{"key":"e_1_2_10_2_75_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950050111"},{"key":"e_1_2_10_2_76_2","first-page":"495","article-title":"Surgical risk factors in Larsen's syndrome.","volume":"66","author":"Karakas K","year":"2000","journal-title":"Acta Orthop Belg"},{"key":"e_1_2_10_2_77_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348947608500408"},{"key":"e_1_2_10_2_78_2","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1542\/peds.88.4.834","article-title":"Gastroesophageal reflux, as measured by 24\u2010hour pH monitoring, in 509 healthy infants screened for risk of sudden infant death syndrome.","volume":"88","author":"Vandenplas Y","year":"1991","journal-title":"Pediatrics"},{"key":"e_1_2_10_2_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)00352-6"},{"key":"e_1_2_10_2_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(99)70327-X"},{"key":"e_1_2_10_2_81_2","first-page":"135","article-title":"The clinical and physiological manifestations of the infantile larynx: Natural history and relationship\u2010mental retardation.","volume":"7","author":"Phelan PD","year":"1971","journal-title":"Aust Paediatr J"},{"issue":"2","key":"e_1_2_10_2_82_2","first-page":"7","article-title":"Laryngopharyngeal reflux is different from classic gastroesophageal reflux disease.","volume":"81","author":"Koufman JA","year":"2002","journal-title":"ENT J"},{"key":"e_1_2_10_2_83_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2002.125760"},{"issue":"2","key":"e_1_2_10_2_84_2","first-page":"14","article-title":"Laryngopharyngeal reflux testing.","volume":"81","author":"Postma GN","year":"2002","journal-title":"ENT J"},{"key":"e_1_2_10_2_85_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348940010901103"},{"key":"e_1_2_10_2_86_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200100002-00001"},{"key":"e_1_2_10_2_87_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200209000-00014"},{"key":"e_1_2_10_2_88_2","first-page":"169","article-title":"Extraesophageal pediatric reflux: 24\u2010hour double\u2010probe pH monitoring in 222 children.","volume":"106","author":"Little JP","year":"1997","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"e_1_2_10_2_89_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.1991.101.s53.1"},{"key":"e_1_2_10_2_90_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2002.125603"},{"issue":"2","key":"e_1_2_10_2_91_2","first-page":"19","article-title":"Clinical manifestations of laryngopharyngeal reflux.","volume":"81","author":"Cohen JT","year":"2002","journal-title":"ENT J"},{"issue":"2","key":"e_1_2_10_2_92_2","first-page":"10","article-title":"Symptoms and findings of laryngopharyngeal reflux.","volume":"81","author":"Belafsky PC","year":"2002","journal-title":"ENT J"},{"key":"e_1_2_10_2_93_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.119.2.409"},{"key":"e_1_2_10_2_94_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949910800411"},{"key":"e_1_2_10_2_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(02)00284-7"},{"key":"e_1_2_10_2_96_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(87)80152-X"},{"key":"e_1_2_10_2_97_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00168491"},{"key":"e_1_2_10_2_98_2","first-page":"1761","volume-title":"Textbook of Primary Care Medicine","author":"Shapiro A","year":"2001"},{"key":"e_1_2_10_2_99_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)83325-6"},{"key":"e_1_2_10_2_100_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100118158"},{"key":"e_1_2_10_2_101_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348948709600606"},{"key":"e_1_2_10_2_102_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(00)80120-9"},{"key":"e_1_2_10_2_103_2","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0030-6665(20)32660-8","article-title":"Medical management, nasotracheal intubation, and tracheotomy in the treatment of upper airway obstruction in children.","volume":"10","author":"Gross CW","year":"1977","journal-title":"Otolaryngol Clin North Am"},{"key":"e_1_2_10_2_104_2","volume-title":"Le Larynx de l'Enfant","author":"Narcy P","year":"1970"},{"key":"e_1_2_10_2_105_2","first-page":"9","volume-title":"Competrendu du Congres de la Societe d'ORL et de Pathologie Cervicofaciale; 1976","author":"Narcy P","year":"1976"},{"key":"e_1_2_10_2_106_2","first-page":"625","article-title":"Un cas de stridor larynge congenigtal grave laoite pan hyomandibulopexie (a case of severe congenital laryngeal stridor treated by hyomandibulopexy.","volume":"20","author":"Cagnol C","year":"1971","journal-title":"J Fr Otorhinolaryngol"},{"key":"e_1_2_10_2_107_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348947108000508"},{"key":"e_1_2_10_2_108_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199207000-00029"},{"key":"e_1_2_10_2_109_2","first-page":"223","article-title":"Zur pathogenese, diagnostik und therapeutik des stridor congenitus.","volume":"21","author":"Hasslinger F","year":"1928","journal-title":"Ztschr JHals Nasen Ohrenheilkd"},{"key":"e_1_2_10_2_110_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-193001000-00008"},{"key":"e_1_2_10_2_111_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1953.00710040265002"},{"key":"e_1_2_10_2_112_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1992.01880060104021"},{"key":"e_1_2_10_2_113_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100047903"},{"key":"e_1_2_10_2_114_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197601000-00018"},{"key":"e_1_2_10_2_115_2","first-page":"1","article-title":"Uber den werth gewisser einzelsymptome fur die diagnose mancher krankheiten des kindesalters.","volume":"21","author":"Pollitzer LM","year":"1884","journal-title":"Jahrb F Kinderh"},{"key":"e_1_2_10_2_116_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949710601101"},{"key":"e_1_2_10_2_117_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949210100405"},{"key":"e_1_2_10_2_118_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198806000-00016"},{"key":"e_1_2_10_2_119_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199004000-00008"},{"key":"e_1_2_10_2_120_2","first-page":"R30","article-title":"Properties of the laryngeal chemoreflex in neonatal piglets.","volume":"233","author":"Lee JC","year":"1977","journal-title":"Am J Physiol"},{"key":"e_1_2_10_2_121_2","first-page":"122","article-title":"Neurosensory deficit of the hypopharynx in patients with Parkinson's disease and dysphagia: an unrecognized etiology of aspiration.","volume":"13","author":"Link DT","year":"1998","journal-title":"Dysphagia"},{"key":"e_1_2_10_2_122_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(03)00217-1"},{"key":"e_1_2_10_2_123_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000225942.33102.9b"},{"key":"e_1_2_10_2_124_2","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001580208"},{"key":"e_1_2_10_2_125_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091400204"},{"key":"e_1_2_10_2_126_2","first-page":"491","volume-title":"Sudden Infant Death Syndrome","author":"Munger BL","year":"1983"},{"key":"e_1_2_10_2_127_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(68)90080-0"},{"key":"e_1_2_10_2_128_2","doi-asserted-by":"publisher","DOI":"10.1002\/neu.480070603"},{"key":"e_1_2_10_2_129_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949310201007"},{"key":"e_1_2_10_2_130_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00009561"},{"key":"e_1_2_10_2_131_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949910800802"},{"key":"e_1_2_10_2_132_2","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1542\/peds.55.5.640","article-title":"Laryngeal chemosensitivity: a possible mechanism for sudden infant death.","volume":"55","author":"Downing SE","year":"1975","journal-title":"Pediatrics"},{"key":"e_1_2_10_2_133_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199311000-00006"},{"key":"e_1_2_10_2_134_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199806000-00015"},{"key":"e_1_2_10_2_135_2","first-page":"969","article-title":"Frequency and significance of swallowing during prolonged apnea in infants.","volume":"130","author":"Menon AP","year":"1984","journal-title":"Am Rev Respir Dis"},{"key":"e_1_2_10_2_136_2","doi-asserted-by":"publisher","DOI":"10.1177\/019459988709700106"},{"key":"e_1_2_10_2_137_2","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1542\/peds.68.6.796","article-title":"An animal model for airway sensory deprivation producing obstructive apnea with postmortem findings of sudden infant death syndrome.","volume":"68","author":"Abu\u2010Osba YK","year":"1981","journal-title":"Pediatrics"},{"key":"e_1_2_10_2_138_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(85)80091-3"},{"key":"e_1_2_10_2_139_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/137.1.113"},{"key":"e_1_2_10_2_140_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.80.2.472"},{"key":"e_1_2_10_2_141_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(97)00336-7"},{"key":"e_1_2_10_2_142_2","first-page":"180A","article-title":"Airway response to esophageal and tracheal acidification: a possible mechanism of the association of gastroesophageal reflux and bronchospasm.","volume":"16","author":"Tuchman DN","year":"1982","journal-title":"Pediatr Res"},{"key":"e_1_2_10_2_143_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1988.64.4.1412"},{"key":"e_1_2_10_2_144_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/139.3.668"},{"key":"e_1_2_10_2_145_2","first-page":"353","article-title":"The cardiovascular response to laryngeal water administration in young lambs.","volume":"4","author":"Grogaard J","year":"1982","journal-title":"J Dev Physiol"},{"key":"e_1_2_10_2_146_2","doi-asserted-by":"publisher","DOI":"10.1159\/000241157"},{"key":"e_1_2_10_2_147_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949410301001"},{"key":"e_1_2_10_2_148_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949610500202"},{"key":"e_1_2_10_2_149_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199709000-00018"},{"key":"e_1_2_10_2_150_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(97)00327-6"},{"key":"e_1_2_10_2_151_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59989770268-7"},{"key":"e_1_2_10_2_152_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949710600201"},{"key":"e_1_2_10_2_153_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1997.01900020034005"},{"key":"e_1_2_10_2_154_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949810700503"},{"key":"e_1_2_10_2_155_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348940010901002"},{"key":"e_1_2_10_2_156_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.1.9811043"},{"key":"e_1_2_10_2_157_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348940511400402"},{"issue":"1","key":"e_1_2_10_2_158_2","first-page":"S23","article-title":"Laryngopharyngeal manifestations of reflux: diagnosis and therapy.","volume":"14","author":"Close LG","year":"2002","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"e_1_2_10_2_159_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)00354-X"},{"key":"e_1_2_10_2_160_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(01)00860-9"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1097%2FMLG.0b013e31804a5750","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/MLG.0b013e31804a5750","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T02:06:56Z","timestamp":1695607616000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/MLG.0b013e31804a5750"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":256,"journal-issue":{"issue":"S114","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["10.1097\/MLG.0b013e31804a5750"],"URL":"https:\/\/doi.org\/10.1097\/mlg.0b013e31804a5750","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6]]}}}