{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:30:28Z","timestamp":1767652228005},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,1,2]],"date-time":"2009-01-02T00:00:00Z","timestamp":1230854400000},"content-version":"vor","delay-in-days":551,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objectives\/Hypothesis:<\/jats:bold> We have previously shown that gene therapy using Insulin\u2010like growth factor (IGF)\u2010I, glial cell line\u2010derived neurotrophic factor (GDNF), and brain\u2010derived neurotrophic factor (BDNF), or a combination of these trophic factors, is a treatment option for recurrent laryngeal nerve (RLN) palsy. However, there remain some difficulties preventing this option from becoming a common clinical therapy for RLN injury. Thus, we need to develop novel treatment option that overcomes the problems of gene therapy.<\/jats:p><jats:p>R(\u2014)\u20101\u2010(benzothiophen\u20105\u2010yl)\u20102\u2010[2\u2010N,N\u2010diethylamino]ethoxy]ethanol hydrochloride (T\u2010588), a synthetic compound, is known to have neuroprotective effects on neural cells. In the present study, the possibility of new drug treatments using T\u2010588 for RLN injury was assessed using rat models.<\/jats:p><jats:p><jats:bold>Study Design:<\/jats:bold> Animal study.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Animals were administered T\u2010588 for 4 weeks. The neuroprotective effects of T\u2010588 administration after vagal nerve avulsion and neurofunctional recovery after recurrent laryngeal nerve crush were studied using motoneuron cell counting, evaluation of choline acetyltransferase immunoreactivity, the electrophysiologic examination, and the re\u2010mobilization of the vocal fold.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> T\u2010588 administration successfully prevented motoneuron loss and ameliorated the choline acetyltransferase immunoreactivity in the ipsilateral nucleus ambiguus after vagal nerve avulsion. Significant improvements of motor nerve conduction velocity of the RLN and vocal fold movement were observed in the treatment group when compared to controls.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> These results indicate that oral administration of T\u2010588 might be a promising therapeutic option in treating peripheral nerve injury.<\/jats:p>","DOI":"10.1097\/mlg.0b013e31805f681f","type":"journal-article","created":{"date-parts":[[2007,5,16]],"date-time":"2007-05-16T08:02:53Z","timestamp":1179302573000},"page":"1313-1318","source":"Crossref","is-referenced-by-count":15,"title":["A Novel Drug Therapy for Recurrent Laryngeal Nerve Injury Using 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