{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T15:20:59Z","timestamp":1780586459217,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2009,1,2]],"date-time":"2009-01-02T00:00:00Z","timestamp":1230854400000},"content-version":"vor","delay-in-days":520,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objectives\/Hypothesis:<\/jats:bold> Early recovery and pain management after endoscopic sinus surgery (ESS) are largely unexplored regardless of the large number of ESSs performed by otorhinolaryngologists. In the present study, we evaluated whether scheduled administration of acetaminophen (paracetamol) for pain management after ESS would allow faster recovery to normal daily activities compared with acetaminophen administered on an as needed basis.<\/jats:p><jats:p><jats:bold>Study Design:<\/jats:bold> Open, prospective, randomized, controlled clinical trial with two parallel groups.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> There were 78 patients who were undergoing ESS and were randomized into two groups. The \u201cscheduled\u201d group (n = 38) was instructed to take two acetaminophen 665 mg modified\u2010release tablets three times a day during the first five postoperative days, whereas the \u201cas needed\u201d group (n = 40) was given instructions to use acetaminophen 665 mg tablets only on an as needed basis. Patients filled in a questionnaire at the follow\u2010up visits on the 7th and 30th postoperative days. The main outcome measures were return to normal daily activities (primary endpoint) and pain during the first week after surgery and patients' satisfaction with pain management (secondary endpoints).<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Patients returned to their normal daily activities in 8.8 (SD 4.8) days in the \u201cscheduled\u201d group versus in 10.3 (SD 7.0) days in the \u201cas needed\u201d group (mean difference 1.5; 95% CI of the difference \u20131.3 to 4.2; <jats:italic>P<\/jats:italic> = .29). In the \u201cscheduled\u201d group, the mean of worst pain was 3.4 (2.9) compared with 5.2 (3.0) in the \u201cas needed\u201d group on an 11\u2010point scale (mean difference 1.7; 95% CI of the difference 0.4\u20135.2; <jats:italic>P<\/jats:italic> = .019). The patients in both groups were equally satisfied with pain management.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> The present study suggests that patients recover in 9 to 10 days after ESS when provided with appropriate pain management. Our data indicate that by prescribing scheduled acetaminophen, postoperative pain after ESS can be controlled effectively without the need for opioid analgesics.<\/jats:p>","DOI":"10.1097\/mlg.0b013e3180600a16","type":"journal-article","created":{"date-parts":[[2007,6,15]],"date-time":"2007-06-15T08:04:30Z","timestamp":1181894670000},"page":"1434-1438","source":"Crossref","is-referenced-by-count":34,"title":["Pain Treatment and Recovery After Endoscopic Sinus Surgery"],"prefix":"10.1002","volume":"117","author":[{"given":"Tatu P","family":"Kemppainen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henri","family":"Tuomilehto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannu","family":"Kokki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha","family":"Sepp\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juhani","family":"Nuutinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,2]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199511000-00023"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200209000-00025"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03018885"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.2001.00433.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6815-4-2"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00045391-200007020-00003"},{"key":"e_1_2_6_8_2","doi-asserted-by":"crossref","unstructured":"BardenJ EdwardsJ MooreA McQuayH.Single dose oral paracetamol (acetaminophen) for postoperative pain. 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