{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T01:01:14Z","timestamp":1781658074287,"version":"3.54.5"},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2009,1,2]],"date-time":"2009-01-02T00:00:00Z","timestamp":1230854400000},"content-version":"vor","delay-in-days":520,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objectives:<\/jats:bold> To evaluate the time course and extent of the restenosis that occurs after an endoscopic modified Lothrop procedure (EMLP) and to identify factors that contribute to this process.<\/jats:p><jats:p><jats:bold>Study Design:<\/jats:bold> Retrospective study of prospectively collected data.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Seventy\u2010seven consecutive patients undergoing EMLP between November 1998 and June 2005 with frontal ostium measurements documented intraoperatively and at follow\u2010up visits for a minimum of 12 months were included. Data on patient demographics, medical history, comorbidities, and computed tomography scans were collected.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Significant restenosis of the frontal sinus neo\u2010ostia was defined as a loss of more than 60% of the original intraoperative area. The mean follow\u2010up in our cohort was 29.2 months. Twenty\u2010two patients were identified with increased stenosis, all of which arose within the first 12 months postsurgery. Nine of these 22 patients required revision EMLP. In all patients, the new frontal ostium narrowed at 1 year by an average of 33% (from 290 to 191 mm<jats:sup>2<\/jats:sup>, confidence interval 159\u2013223 mm<jats:sup>2<\/jats:sup>). Restenosis and revision surgery are partly predicted by the presence of eosinophilic mucin chronic rhinosinusitis as demonstrated by logistic regression analysis. Linear regression analysis confirmed that the intraoperative frontal ostium size determines the frontal ostium area at 1 year.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> This study provides benchmarking values for the time course of the frontal ostium area after EMLP for normal wound healing and increased stenosis. On the basis of our results, patients with a higher risk for developing restenosis and of having revision surgery can be identified preoperatively and during the early postoperative period to facilitate special postoperative care.<\/jats:p>","DOI":"10.1097\/mlg.0b013e31806865be","type":"journal-article","created":{"date-parts":[[2007,6,21]],"date-time":"2007-06-21T08:03:10Z","timestamp":1182412990000},"page":"1457-1462","source":"Crossref","is-referenced-by-count":103,"title":["Frontal Ostium Restenosis After the Endoscopic Modified Lothrop Procedure"],"prefix":"10.1002","volume":"117","author":[{"given":"Khanh N.","family":"Tran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achim G.","family":"Beule","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepti","family":"Singal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter\u2010John","family":"Wormald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,2]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200302000-00015"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59989570080-3"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59980301306-8"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200101000-00024"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200107000-00030"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/194589240201600206"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.2004.00824.x"},{"key":"e_1_2_6_9_2","first-page":"183","article-title":"Staging in rhinosinusitis","volume":"31","author":"Lund VJ","year":"1993","journal-title":"Rhinology"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000161341.00258.54"},{"key":"e_1_2_6_11_2","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Development Core team","year":"2006"},{"key":"e_1_2_6_12_2","first-page":"1721","article-title":"MR evaluation of frontal sinus osteoplastic flaps with autogenous fat grafts","volume":"16","author":"Loevner LA","year":"1995","journal-title":"Am J Neuroradiol"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.2500\/105065898780182444"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.124.10.1090"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.03.049"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000224547.14519.ad"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1097%2FMLG.0b013e31806865be","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/MLG.0b013e31806865be","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T13:19:40Z","timestamp":1699967980000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/MLG.0b013e31806865be"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8]]},"references-count":15,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["10.1097\/MLG.0b013e31806865be"],"URL":"https:\/\/doi.org\/10.1097\/mlg.0b013e31806865be","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8]]}}}