{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:20:36Z","timestamp":1759335636540},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2009,1,2]],"date-time":"2009-01-02T00:00:00Z","timestamp":1230854400000},"content-version":"vor","delay-in-days":489,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objectives:<\/jats:bold> We aimed to identify the functional abnormality of sinusitis\u2010affected mucosa by observing the responsiveness of the mucosa to purinergic stimulation after the onset of sinusitis and during the recovery period. We also aimed to identify possible beneficial effects of purinergic agonists on sinusitis.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A rabbit sinusitis model was developed by blocking maxillary ostia. Sinus mucosae were harvested immediately and 1 and 4 weeks after reopening the ostia. We measured chloride secretion and ciliary beat frequencies responding to purinergic stimulation.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The increases of ciliary beat frequency by adenosine triphosphate (100 \u03bcmol\/L) were 3.2% \u00b1 8.5%, 7.9% \u00b1 2.3%, and 12.2% \u00b1 1.9% immediately after establishment of sinusitis and 1 week and 4 weeks after reopening of ostia, respectively. Chloride secretion stimulated by adenosine triphosphate also showed gradual increase during the recovery period. Grossly, the mucosae appeared to have normalized in 80% (4 of 5) after 4 weeks; however, functional and microscopic improvements were still incomplete.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Mucosal functions, assessed by increase of ciliary activity and ion secretion by purinergic stimulation, and microscopic findings showed gradual but incomplete recovery after 4 weeks of recovery, in contrast to the gross normalization. Purinergic agonists may have beneficial effects on sinusitis by stimulating decreased ciliary motility and chloride secretion in sinusitis.<\/jats:p>","DOI":"10.1097\/mlg.0b013e31806911cc","type":"journal-article","created":{"date-parts":[[2007,7,13]],"date-time":"2007-07-13T08:50:32Z","timestamp":1184316632000},"page":"1677-1682","source":"Crossref","is-referenced-by-count":5,"title":["Effects of Purinergic Stimulation on Ciliary Beat Frequency and Chloride Secretion in Sinusitis"],"prefix":"10.1002","volume":"117","author":[{"given":"In\u2010Sang","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chae\u2010Seo","family":"Rhee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun Ho","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong\u2010Hwa","family":"Heo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerry","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chul Hee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,2]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.41.6.453"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1985.00800110054002"},{"key":"e_1_2_6_4_2","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1177\/194589240101500402","article-title":"Evaluation of ultrastructural changes in paranasal sinus mucosa after functional endoscopic sinus surgery in patients with chronic rhinosinusitis","volume":"15","author":"Keles N","year":"2001","journal-title":"Am J Rhinol"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016480310005110"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016489109100768"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.14.1814"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.153.6.8665037"},{"key":"e_1_2_6_9_2","doi-asserted-by":"crossref","first-page":"C1484","DOI":"10.1152\/ajpcell.2001.280.6.C1485","article-title":"Differential effects of UTP, ATP and adenosine on ciliary activity of human nasal epithelial cells","volume":"280","author":"Morse D","year":"2001","journal-title":"J Physiol Cell Physiol"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(94)80987-7"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02510966"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2001.013222"},{"key":"e_1_2_6_13_2","doi-asserted-by":"crossref","first-page":"L258","DOI":"10.1152\/ajplung.1998.274.2.L258","article-title":"Inhibition of airway liquid secretion and its effect on the physical properties of airway mucus","volume":"18","author":"Trout L","year":"1998","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00048.2004"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03256658"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.44.27830"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1097%2FMLG.0b013e31806911cc","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/MLG.0b013e31806911cc","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T22:28:40Z","timestamp":1696890520000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/MLG.0b013e31806911cc"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9]]},"references-count":15,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["10.1097\/MLG.0b013e31806911cc"],"URL":"https:\/\/doi.org\/10.1097\/mlg.0b013e31806911cc","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,9]]}}}