{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T16:52:26Z","timestamp":1788540746602,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2009,1,2]],"date-time":"2009-01-02T00:00:00Z","timestamp":1230854400000},"content-version":"vor","delay-in-days":489,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objectives:<\/jats:bold> Lemierre syndrome is usually caused by an acute oropharyngeal infection in previously healthy young adults, resulting in thrombophlebitis of the internal jugular vein, leading to metastatic septic embolization and bacteraemia. The usual organism is <jats:italic>Fusobacterium necrophorum<\/jats:italic>. Lemierre syndrome, not so long ago labeled as the \u201cforgotten disease,\u201d is on the rise. Today with increasing antibiotic\u2010resistant organisms, and decreasing awareness of the syndrome, subsequent re\u2010emergence of this \u201cforgotten disease\u201d is becoming more common in clinical settings. Lemierre syndrome has significant morbidity. Cranial nerve complications associated with the condition have been increasingly diagnosed in the last few years. Looking back at literature on Lemierre syndrome, there have been review articles in medical and microbiology journals but rarely in otolaryngology journals. By presenting our cases we demonstrate the diverse presentations and severity of the illness.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A review of the literature and a case report on two cases seen in our institution in the last year are presented. Each of these had varied presentations and neurologic complications\u2014one developed 9th to 12th cranial nerve palsies and Horner syndrome, which have not been described in previous literature, and the other developed polyneuropathy and a frontal lobe infarct among other multisystem complications.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Diagnosis of Lemierre syndrome is not always straightforward as clinical features are variable and blood cultures are often negative. Awareness of the syndrome and a high degree of suspicion are needed.<\/jats:p>","DOI":"10.1097\/mlg.0b013e318093ee0e","type":"journal-article","created":{"date-parts":[[2007,8,23]],"date-time":"2007-08-23T07:01:34Z","timestamp":1187852494000},"page":"1605-1610","source":"Crossref","is-referenced-by-count":113,"title":["Lemierre Syndrome: Two Cases and a Review"],"prefix":"10.1002","volume":"117","author":[{"given":"Mohammed Iqbal","family":"Syed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Baring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Addidle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Murray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calum","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,2]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)57035-4"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198903000-00002"},{"key":"e_1_2_5_4_2","first-page":"41","article-title":"Necrobacillosis","volume":"62","author":"Eykyn SJ","year":"1989","journal-title":"Scand J Infect Dis Suppl"},{"key":"e_1_2_5_5_2","first-page":"384","article-title":"Lemierre syndrome: postanginal sepsis","volume":"8","author":"Leugers CM","year":"1995","journal-title":"J Am Board Fam Pract"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0278-2391(94)90019-1"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.288.6429.1526"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01708619"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200211000-00006"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004310050730"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)05261-6"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1258\/0022215001906110"},{"key":"e_1_2_5_13_2","doi-asserted-by":"crossref","first-page":"E22","DOI":"10.1053\/ajkd.2001.22099","article-title":"Hemolytic uremic syndrome in an adolescent with Fusobacterium necrophorum bacteremia","volume":"37","author":"Chand DH","year":"2001","journal-title":"Am J Kidney Dis"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2003.10.013"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1017\/S002221510600034X"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2005.081851"},{"key":"e_1_2_5_17_2","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1177\/0310057X9802600518","article-title":"Cardiac tamponade in a postpartum woman with Lemierre's syndrome","volume":"26","author":"McLean AS","year":"1998","journal-title":"Anasesth Intensive Care"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.75.881.141"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-005-1298-6"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-51-3-269"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-198806000-00008"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-83-3-375"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1097%2FMLG.0b013e318093ee0e","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/MLG.0b013e318093ee0e","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T22:27:26Z","timestamp":1696890446000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/MLG.0b013e318093ee0e"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9]]},"references-count":21,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["10.1097\/MLG.0b013e318093ee0e"],"URL":"https:\/\/doi.org\/10.1097\/mlg.0b013e318093ee0e","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,9]]}}}