{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T16:58:16Z","timestamp":1771779496346,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2009,1,2]],"date-time":"2009-01-02T00:00:00Z","timestamp":1230854400000},"content-version":"vor","delay-in-days":489,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objective:<\/jats:bold> Evaluate the sensitivity of quality of life (QoL) instruments over time in patients with M\u00e9ni\u00e8re's disease using general, symptom\u2010specific, and disease\u2010specific QoL instruments.<\/jats:p><jats:p><jats:bold>Study Design:<\/jats:bold> Prospective study using QoL instruments administered serially over 4 months in patients undergoing treatment for M\u00e9ni\u00e8re's disease.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Sixty\u2010one people aged 33 to 71 years with active, unilateral, cochleovestibular M\u00e9ni\u00e8re's disease refractory to medical management completed two general QoL instruments, Sense of Coherence (SOC) and World Health Organization Quality of Life\u2013Abbreviated Version (WHOQOL\u2010BREF), one symptom\u2010specific QoL instrument, Vertigo Symptom Scale (VSS), and one disease\u2010specific QoL instrument, M\u00e9ni\u00e8re's Disease Patient Oriented Severity Index (MDPOSI). All measures were administered at baseline and again 2 and 4 months later.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Disease\u2010 and symptom\u2010specific instruments including the MDPOSI and VSS were positively correlated with vertigo control category (Pearson's <jats:italic>R<\/jats:italic> = 0.345, MDPOSI; 0.279, VSS), indicating sensitivity to the frequency of vertigo spells. These instruments were also sensitive to changes in vertigo over time. Standardized response means showed greatest responsiveness to change on the MDPOSI (0.80) and the VSS (0.79). Standardized response means for SOC and WHOQOL\u2010BREF were 0.03, and 0.32, respectively, suggesting poor responsiveness to change of symptoms. The VSS and MDPOSI were highly correlated (Pearson's <jats:italic>r<\/jats:italic> coefficient 0.744; <jats:italic>P<\/jats:italic> &lt; .001).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> A disease\u2010specific QoL instrument such as the MDPOSI and a symptom\u2010specific instrument such as the VSS more accurately reflect changes in control of vertigo in people with M\u00e9ni\u00e8re's disease over time than do general QoL instruments. These instruments can be used to determine the life impact of M\u00e9ni\u00e8re's disease and how aggressive therapy should be for the patient.<\/jats:p>","DOI":"10.1097\/mlg.0b013e3180caa14f","type":"journal-article","created":{"date-parts":[[2007,7,19]],"date-time":"2007-07-19T08:04:59Z","timestamp":1184832299000},"page":"1622-1628","source":"Crossref","is-referenced-by-count":26,"title":["Quality of Life Instruments in M\u00e9ni\u00e8re's Disease"],"prefix":"10.1002","volume":"117","author":[{"suffix":"Jr","given":"J Douglas","family":"Green","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aimee","family":"Verrall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George A.","family":"Gates","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,2]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"597","article-title":"Pathologie auriculaire: memoires sur de l\u00e9sions de l'oreille intern donnant lieu \u00e0 des sympt\u00f4mes de congestion c\u00e9r\u00e9brale apoplectiforme","volume":"16","author":"M\u00e9ni\u00e8re P","year":"1861","journal-title":"Gaz Med Paris"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100003947"},{"key":"e_1_2_7_4_2","first-page":"2310","article-title":"Uber die pathologische Veranderung bei einem Meniere\u2010Kranken","volume":"4","author":"Yamakawa K","year":"1938","journal-title":"J Otorhinolaryngol Soc Jpn"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/019459989110400603"},{"key":"e_1_2_7_6_2","first-page":"72","article-title":"The natural course of M\u00e9ni\u00e8re's disease","volume":"406","author":"Friberg U","year":"1984","journal-title":"Acta Otolaryngol Suppl"},{"key":"e_1_2_7_7_2","first-page":"67","article-title":"Long\u2010term effects of M\u00e9ni\u00e8re's disease on hearing and quality of life","volume":"18","author":"Kinney SE","year":"1997","journal-title":"Am J Otol"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200410000-00031"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2004.08.012"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200107000-00020"},{"key":"e_1_2_7_11_2","first-page":"67","article-title":"Long\u2010term effects of M\u00e9ni\u00e8re's disease on hearing and quality of life","volume":"18","author":"Kinney SE","year":"1997","journal-title":"Am J Otol"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200405000-00023"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000171017.41592.d0"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.130.6.718"},{"key":"e_1_2_7_15_2","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0194-5998(95)70102-8","volume":"113","author":"Committee on Hearing and Equilibrium guidelines for the diagnosis and evaluation of therapy in M\u00e9ni\u00e8re's disease. 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