{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T01:32:10Z","timestamp":1785461530937,"version":"3.56.0"},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2009,1,2]],"date-time":"2009-01-02T00:00:00Z","timestamp":1230854400000},"content-version":"vor","delay-in-days":398,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2007,12]]},"abstract":"Abstract<\/jats:title>Objectives\/Hypothesis:<\/jats:bold> Among the airway mucin genes, the MUC4<\/jats:italic> gene is an important gene in its response to inflammatory diseases of the upper airway. However, the expression and regulation of the MUC4<\/jats:italic> gene in the nasal polyps remains unclear.<\/jats:p>Study Design:<\/jats:bold> The purpose of this study was to evaluate the expression of MUC4<\/jats:italic> mRNA and synthesis of mucin glycoprotein in the nasal polyps before and after treatment with a topical steroid in vivo and in vitro.<\/jats:p>Methods:<\/jats:bold> Nasal polyps were obtained from 20 patients with chronic rhinosinusitis and were subsequently cultured. The level of MUC4<\/jats:italic> mRNA was measured by reverse\u2010transcription polymerase chain reaction, and the amount of the MUC4<\/jats:italic> mucin glycoprotein was estimated by the enzyme\u2010linked immunosorbent assay method.<\/jats:p>Results:<\/jats:bold> The expression of MUC4<\/jats:italic> mRNA was found to be significantly higher in the nasal polyps than in the inferior turbinate (P<\/jats:italic> < .05). The addition of interleukin (IL)\u20101\u03b2 and lipopolysaccharide (LPS) increased the expression of MUC4<\/jats:italic> mRNA and mucin glycoprotein synthesis in cultured nasal polyp epithelial cells. Treatment with glucocorticoid inhibited the expression of MUC4<\/jats:italic> mRNA in the nasal polyps; it also inhibited the expression of IL\u20101\u03b2 and LPS\u2010induced MUC4<\/jats:italic> mRNA and mucin glycoprotein synthesis in cultured nasal polyp epithelial cells. The inhibitory effects of glucocorticoid were restored by treatment with a glucocorticoid receptor antagonist (RU\u2010486).<\/jats:p>Conclusions:<\/jats:bold> These results suggest that the MUC4<\/jats:italic> gene is expressed in the nasal polyps and that glucocorticoid can control the expression of the MUC4<\/jats:italic> gene and mucin glycoprotein synthesis.<\/jats:p>","DOI":"10.1097\/mlg.0b013e31813e5fef","type":"journal-article","created":{"date-parts":[[2009,2,19]],"date-time":"2009-02-19T21:01:43Z","timestamp":1235077303000},"page":"2169-2173","source":"Crossref","is-referenced-by-count":17,"title":["Effect of Glucocorticoid on the MUC4<\/i> Gene in Nasal Polyps"],"prefix":"10.1002","volume":"117","author":[{"given":"Chang Hoon","family":"Bai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si\u2010Youn","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010Dae","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,2]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.3107"},{"key":"e_1_2_6_3_2","first-page":"4083","article-title":"Two novel mucin genes down\u2010regulated in colorectal cancer identified by differential display.","volume":"59","author":"Williams SJ","year":"1999","journal-title":"Cancer Res"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.62.5.1112"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3301301"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203781"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016480510027538"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2006.02451.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.2000.00350.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200002010-00017"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3320739"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/bies.10201"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/10.1.98"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910570212"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016480260000094"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.110476"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1097%2FMLG.0b013e31813e5fef","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/MLG.0b013e31813e5fef","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T03:59:39Z","timestamp":1696910379000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/MLG.0b013e31813e5fef"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":15,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["10.1097\/MLG.0b013e31813e5fef"],"URL":"https:\/\/doi.org\/10.1097\/mlg.0b013e31813e5fef","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12]]}}}