{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:06:49Z","timestamp":1761743209137},"reference-count":8,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2009,1,2]],"date-time":"2009-01-02T00:00:00Z","timestamp":1230854400000},"content-version":"vor","delay-in-days":398,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objectives:<\/jats:bold> To determine the value of preoperative <jats:sup>99m<\/jats:sup>Tc\u2010sestamibi scans and the incidence of ectopic glands in tertiary hyperparathyroidism.<\/jats:p><jats:p><jats:bold>Design:<\/jats:bold> Prospective, non\u2010randomized analysis of a consecutive cohort of surgical patients from the Medical College of Georgia Thyroid\/Parathyroid Center.<\/jats:p><jats:p><jats:bold>Materials and Methods:<\/jats:bold> A consecutive series of patients with tertiary hyperparathyroidism undergoing parathyroidectomy was analyzed. Demographic data, preoperative <jats:sup>99m<\/jats:sup>Tc\u2010sestamibi scintigraphy results, location of diseased glands, pre\u2010 and postoperative calcium, and parathyroid hormone levels were collected.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Twenty\u2010one patients underwent parathyroidectomy for tertiary hyperparathyroidism between March 2004 and September 2006. Of these 21 patients, 3 were re\u2010operative cases for persistent hypercalcemia and each was found to have a single diseased gland. Of the 18 patients undergoing first time surgery, 15 had four\u2010gland hyperplasia, 2 patients had single adenomas, and 1 patient had a double adenoma. Nine of the 21 patients (43%) had ectopic glands (2 of these patients had 2 ectopic glands each). The overall sensitivity of the preoperative <jats:sup>99m<\/jats:sup>Tc\u2010sestamibi scintigraphy was 76% and was not significantly different when comparing patients with ectopic glands (78%) and those without (75%).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> <jats:sup>99m<\/jats:sup>Tc sestamibi scintigraphy has high positive predictive value and sensitivity in patients with tertiary hyperparathyroidism. Sestamibi scanning is particularly valuable in this patient population since the incidence of ectopic glands may be higher than previously recognized.<\/jats:p>","DOI":"10.1097\/mlg.0b013e31813e602a","type":"journal-article","created":{"date-parts":[[2009,3,4]],"date-time":"2009-03-04T23:58:07Z","timestamp":1236211087000},"page":"2135-2138","source":"Crossref","is-referenced-by-count":28,"title":["Value of Sestamibi Scans in Tertiary Hyperparathyroidism"],"prefix":"10.1002","volume":"117","author":[{"given":"Kelly A.","family":"Loftus","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony L.","family":"Mulloy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Terris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,2]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2005.10.049"},{"key":"e_1_2_6_3_2","first-page":"CR86","article-title":"Primary hyperparathyroidism: a review of 177 cases.","volume":"12","author":"Hamidi S","year":"2006","journal-title":"Med Sci Monit"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.124.6.649"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.139.9.974"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197603000-00010"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-005-0279-3"},{"key":"e_1_2_6_8_2","first-page":"1100","article-title":"Parathyroid imaging using simultaneous double window recording of technetium\u201099m\u2010sestamibi and iodine\u2010123.","volume":"39","author":"Hindi\u00e9 E","year":"1998","journal-title":"J Nucl Med"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.065490"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1097%2FMLG.0b013e31813e602a","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/MLG.0b013e31813e602a","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T03:59:16Z","timestamp":1696910356000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/MLG.0b013e31813e602a"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":8,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["10.1097\/MLG.0b013e31813e602a"],"URL":"https:\/\/doi.org\/10.1097\/mlg.0b013e31813e602a","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12]]}}}