{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:10:02Z","timestamp":1785413402169,"version":"3.56.0"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2009,1,2]],"date-time":"2009-01-02T00:00:00Z","timestamp":1230854400000},"content-version":"vor","delay-in-days":398,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objectives:<\/jats:bold> The intratympanic application of a low dosage of gentamicin is increasingly favored as treatment for M\u00e9ni\u00e8re's disease. While posttreatment observations have confirmed a long\u2010term success of the therapy of vertigo attacks, clear differences in the posttreatment recovery interval can be observed. In addition to differences in central\u2010vestibular compensation, the degree of peripheral vestibular damage, i.e., to the saccule, utricle, and semicircular canal ampullae, varies among patients. This study provides comprehensive pre\u2010 and posttreatment results from unilateral functional tests of the individual vestibular receptors and of the cochlea in patients with M\u00e9ni\u00e8re's disease.<\/jats:p><jats:p><jats:bold>Study Design:<\/jats:bold> Prospective clinical study.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Nineteen patients with unilateral M\u00e9ni\u00e8re's disease were treated by intratympanic application of gentamicin by injection of 0.3 mL (12 mg) through the tympanic membrane under local anesthesia. Tests were performed immediately previous to treatment and subsequently in the periods 4 to 8 weeks and 12 to 16 weeks after treatment. Unilateral saccular function was tested by means of acoustic\u2010click, vestibular\u2010evoked myogenic potentials (VEMP), and unilateral utricular function by subjective visual vertical (SVV) during unilateral centrifugation. Bithermal caloric testing was performed to assess unilateral semicircular canal function.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Prior to gentamicin treatment, the caloric response from the diseased ear was normal in 3 patients, below normal in 14 patients, and in 2 cases almost completely absent. VEMP responses could be recorded bilaterally in 13 patients; while in 6, no VEMPs could be measured from the diseased ear. Utricular function measured by SVV estimation was found to be normal in 11 patients and marginally abnormal in 2 patients. In six cases, the SVV was clearly underestimated during centrifugation of the diseased side. The posttreatment findings demonstrate that VEMPs were absent in all treated patients, and the caloric response was abnormally low in all but one case. In contrast, only 12 of 19 patients produced abnormal SVV responses.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The results demonstrate that incremental, intratympanic application of gentamicin effectively eliminates semicircular canal and saccular function. In contrast, utricular function appears to be maintained in 30 to 40% of cases.<\/jats:p>","DOI":"10.1097\/mlg.0b013e3181453a3c","type":"journal-article","created":{"date-parts":[[2009,2,19]],"date-time":"2009-02-19T20:59:10Z","timestamp":1235077150000},"page":"2244-2250","source":"Crossref","is-referenced-by-count":54,"title":["Treatment of M\u00e9ni\u00e8re's Disease by Low\u2010Dosage Intratympanic Gentamicin Application: Effect on Otolith Function"],"prefix":"10.1002","volume":"117","author":[{"given":"Kai","family":"Helling","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Sch\u00f6nfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew H.","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,2]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200401000-00018"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000149439.43478.24"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1987.01860100036017"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(82)80042-2"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348948809700602"},{"key":"e_1_2_6_7_2","first-page":"75","article-title":"Subjective visual horizontal determination during otolith stimulation by eccentric rotation in conservatively treated M\u00e9ni\u00e8re's disease.","volume":"4","author":"Odkvist LM","year":"1998","journal-title":"Int Tinnitus J"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb09202.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.9.1442"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200411000-00020"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016480510033667"},{"key":"e_1_2_6_12_2","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3233\/VES-2005-15106","article-title":"Vestibular function at the end of intratympanic gentamicin treatment of patients with M\u00e9ni\u00e8re's disease.","volume":"15","author":"Perez N","year":"2005","journal-title":"J Vestib Res"},{"key":"e_1_2_6_13_2","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3233\/VES-2005-15304","article-title":"VEMPs and dynamic posturography after intratympanic gentamycin in M\u00e9ni\u00e8re's disease.","volume":"15","author":"Picciotti PM","year":"2005","journal-title":"J Vestib Res"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000161876.20552.AA"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0094-5765(90)90070-2"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/000164801750388180"},{"key":"e_1_2_6_17_2","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3233\/VES-2003-134-606","article-title":"Unilateral examination of utricle and saccule function.","volume":"13","author":"Clarke AH","year":"2003","journal-title":"J Vest Res"},{"key":"e_1_2_6_18_2","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0194-5998(95)70102-8","volume":"113","author":"Committee on Hearing and Equilibrium guidelines for the diagnosis and evaluation of therapy in M\u00e9ni\u00e8re's disease. American Academy of Otolaryngology\u2010Head Neck Surgery","year":"1995","journal-title":"Otolarngol Head Neck Surg"},{"key":"e_1_2_6_19_2","first-page":"168","article-title":"Provoked vestibular nystagmus and caloric reactions after sudden loss of vestibular function.","volume":"27","author":"Scherer H","year":"1981","journal-title":"Adv Otorhinolaryngol"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s101620010053"},{"key":"e_1_2_6_21_2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3233\/VES-2006-161-207","article-title":"Recovery of subjective visual horizontal after unilateral vestibular deafferentation by intratympanic instillation of gentamicin.","volume":"16","author":"Takai Y","year":"2006","journal-title":"J Vestib Res"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200407000-00023"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(94)00175-P"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200108000-00007"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(85)80013-2"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1097%2FMLG.0b013e3181453a3c","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/MLG.0b013e3181453a3c","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T03:59:04Z","timestamp":1696910344000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/MLG.0b013e3181453a3c"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":24,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["10.1097\/MLG.0b013e3181453a3c"],"URL":"https:\/\/doi.org\/10.1097\/mlg.0b013e3181453a3c","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12]]}}}