{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T16:53:52Z","timestamp":1775148832342,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2009,1,2]],"date-time":"2009-01-02T00:00:00Z","timestamp":1230854400000},"content-version":"vor","delay-in-days":398,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objectives:<\/jats:bold> Although many bacteriology studies on tonsillar diseases have been completed, all have been confined to children and were characterized by a paucity of cases. The purpose of this study was to analyze the underlying bacterial pathogens in tonsillar disease.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A retrospective study was performed on 824 patients who underwent elective tonsillectomy with or without adenoidectomy. We analyzed the differences between the bacterial pathogens in recurrent tonsillitis and tonsillar hypertrophy with regard to age, season, and antibiotic sensitivity.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Among 824 cases, 966 bacterial strains from the tonsil core were isolated. In recurrent tonsillitis, <jats:italic>Staphylococcus aureus<\/jats:italic> was the most common pathogen (30.3%), followed by <jats:italic>Haemophilus influenzae<\/jats:italic> (15.5%) and group A \u03b2\u2010hemolytic <jats:italic>Streptococcus<\/jats:italic> (<jats:italic>Streptococcus pyogenes<\/jats:italic>, 14.4%). In patients over 14 years of age, quite differently from other age groups, <jats:italic>Klebsiella pneumoniae<\/jats:italic> was isolated at a significantly higher percentage. In tonsillar hypertrophy, <jats:italic>H. influenzae<\/jats:italic> was isolated most commonly (31.4%) regardless of age, followed by <jats:italic>S. pyogenes<\/jats:italic> (24.2%), <jats:italic>S. aureus<\/jats:italic> (22.9%), and <jats:italic>Streptococcus pneumoniae<\/jats:italic> (12.6%). Furthermore, mixed infection was common because of its high resistance to penicillin. In both groups, <jats:italic>S. pneumoniae<\/jats:italic> was more common in younger patients, whereas <jats:italic>K. pneumoniae<\/jats:italic> was relatively common in adults. We found no differences in the detection rate by season; however, <jats:italic>H. influenzae<\/jats:italic> was frequently isolated in the tonsillar hypertrophy group regardless of seasonal variations. We also found no difference in the antibiotic sensitivity between the two groups; however, strains resistant to penicillin were relatively prevalent and showed a high sensitivity to third\u2010generation cephalosporin.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> We observed some differences in the types of bacteria in the tonsillar core between the recurrent tonsillitis and tonsillar hypertrophy groups. Our study indicates that essential bacteria have been changing and, thus, we need to change our choice of antibiotics.<\/jats:p>","DOI":"10.1097\/mlg.0b013e31814543c8","type":"journal-article","created":{"date-parts":[[2009,2,19]],"date-time":"2009-02-19T21:03:21Z","timestamp":1235077401000},"page":"2146-2151","source":"Crossref","is-referenced-by-count":65,"title":["Bacteriologic Comparison of Tonsil Core in Recurrent Tonsillitis and Tonsillar Hypertrophy"],"prefix":"10.1002","volume":"117","author":[{"given":"Jin Hyeok","family":"Jeong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Wook","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ri A.","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Sup","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Hwan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Oak","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung","family":"Tae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,2]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01971304"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100084553"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198903000-00005"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949009901209"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1989.01860300075021"},{"key":"e_1_2_6_7_2","first-page":"146","article-title":"Bacteriology of tonsils in children: comparison between recurrent acute tonsillitis and tonsillar hypertrophy.","volume":"47","author":"Francois M","year":"1992","journal-title":"Adv Otorhinolaryngol"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016480310000395"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198810000-00006"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000238168"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0954-6111(06)80182-4"},{"key":"e_1_2_6_12_2","first-page":"130","article-title":"Comparative bacteriology of the surface of normal and pathological palatine tonsils in children.","volume":"523","author":"Endo LH","year":"1996","journal-title":"Acta Otolaryngol"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/45.1.41"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0954-6111(08)80074-1"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1097%2FMLG.0b013e31814543c8","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/MLG.0b013e31814543c8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T03:59:23Z","timestamp":1696910363000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/MLG.0b013e31814543c8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":13,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["10.1097\/MLG.0b013e31814543c8"],"URL":"https:\/\/doi.org\/10.1097\/mlg.0b013e31814543c8","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12]]}}}