{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T20:08:11Z","timestamp":1793045291783,"version":"4.5.0"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,1,2]],"date-time":"2009-01-02T00:00:00Z","timestamp":1230854400000},"content-version":"vor","delay-in-days":336,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:<\/jats:bold> Mucoepidermoid carcinoma (MEC) is one of the most frequent epithelial malignancies of the salivary glands. Prediction of clinical outcome of MEC is challenging.<\/jats:p><jats:p><jats:bold>Material and Methods:<\/jats:bold> We retrospectively reviewed 52 cases of MEC of major salivary gland origin diagnosed at the Department of Otolaryngology\u2013Head and Neck Surgery, Helsinki University Central Hospital, Helsinki, Finland, during a 30\u2010year period of 1976 to 2005. Criteria used for diagnosis were those of World Health Organization classifications valid at each time point, and criteria for grading were those recommended by Armed Forces Institute of Pathology fascicle (1996). Since 1993, the degree of cell proliferation was used at our institution as an adjunct tool when grading MEC. The majority of cases occurred in the parotid gland (n = 47, 90%) followed by the submandibular gland (n = 5, 10%).<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> We had 39% high\u2010grade (HG), 14% intermediate\u2010grade (IMG), and 44% low\u2010grade (LG) MECs. T categories were T1, n = 18; T2, n = 16; T3, n = 9; T4, n = 9. Forty\u2010nine (94%) patients were treated with curative intent. These patients underwent surgery, and 24 (49%) patients received postoperative radiotherapy. Follow\u2010up time varied from 6 months to 9 years. Forty\u2010five percent of HG\u2010MEC patients and 67% of IMG\u2010MEC patients developed locoregional failures or distant metastases during a 3\u2010year follow\u2010up as opposed to none of the LG\u2010MEC patients. Of MEC patients with N0 neck, two HG\u2010MEC patients and one IMG\u2010MEC (8%) patient developed regional recurrence during follow\u2010up.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Patient outcome in the different grades of MEC suggests a need for overview of the treatment protocol, especially with regard to LG\u2010MEC and IMG\u2010MEC. The apparently unusual occurrence of locoregional failures and metastases in LG\u2010MEC suggests a restrictive approach in surgical management. However, the frequent occurrence of such failures in IMG\u2010MEC warrants an aggressive approach with these tumors.<\/jats:p>","DOI":"10.1097\/mlg.0b013e31815a6b0b","type":"journal-article","created":{"date-parts":[[2009,2,19]],"date-time":"2009-02-19T21:18:10Z","timestamp":1235078290000},"page":"258-262","source":"Crossref","is-referenced-by-count":70,"title":["Management and Outcome of Patients With Mucoepidermoid Carcinoma of Major Salivary Gland Origin: A Single Institution's 30\u2010Year Experience"],"prefix":"10.1002","volume":"118","author":[{"given":"Katri","family":"Aro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilmo","family":"Leivo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antti A.","family":"M\u00e4kitie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,2]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2004.01.017"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016480510003174"},{"key":"e_1_2_6_4_2","unstructured":"Finnish Cancer Registry\u2010Institute for Statistical and Epidemiological Cancer Research. Cancer incidence in Finland 2004. Available at:http:\/\/www.cancer.fi. 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