{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:48:23Z","timestamp":1792687703678,"version":"4.5.0"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,1,2]],"date-time":"2009-01-02T00:00:00Z","timestamp":1230854400000},"content-version":"vor","delay-in-days":307,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objective:<\/jats:bold> To assess the feasibility of transoral laser microsurgery (TLM) in the treatment of hypopharyngeal cancer, with a special focus on piriform sinus carcinomas, and to report the oncologic and functional outcomes.<\/jats:p><jats:p><jats:bold>Study Design:<\/jats:bold> Prospective case\u2010series study at a single institute, an academic tertiary referral center.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A total of 172 patients with previously untreated squamous cell carcinoma of the hypopharynx were eligible for this study (1986\u20132003). The piriform sinus was the most common localization (n = 150). Patients with simultaneous second primaries, distant metastases, or N3 neck disease and cancers of the category pT4b were excluded. Fifteen percent of the patients had stages I and II (according to guidelines from the Union Internationale Contre le Cancer 2002\/American Joint Commission on Cancer, 2002), and 85% had stages III and IVa. The median follow\u2010up period was 45 months. All patients (n = 172) were treated by TLM, mainly by selective neck dissection (93%) and\/or postoperative radiotherapy (52%). Overall survival, recurrence\u2010free survival, organ preservation, and local control were analyzed as end points. Rate of tracheotomies, postoperative complications, and swallowing function (feeding tube dependency) were also analyzed.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Five\u2010year Kaplan\u2010Meier local control was 84% for pT1; 70% for pT2; 75% for pT3; and 57% for pT4a. Five\u2010year Kaplan\u2010Meier recurrence\u2010free survival was 73% for stages I and II, 59% for stage III, and 47% for stage IVa. The whole group of 172 hypopharyngeal cancer patients was analyzed, with an additional special focus on the homogenous group of piriform sinus carcinomas (n = 150).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Our data support the conclusion that TLM is a valid option to standard radical surgery or standard conservation treatment. Oncologic and functional results compare favorably, while morbidity and complication rates tend to be lower.<\/jats:p>","DOI":"10.1097\/mlg.0b013e31815aeda3","type":"journal-article","created":{"date-parts":[[2009,3,5]],"date-time":"2009-03-05T13:02:03Z","timestamp":1236258123000},"page":"398-402","source":"Crossref","is-referenced-by-count":124,"title":["Organ Preserving Transoral Laser Microsurgery for Cancer of the Hypopharynx"],"prefix":"10.1002","volume":"118","author":[{"given":"Alexios","family":"Martin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin C.","family":"J\u00e4ckel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Christiansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Mahmoodzada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Kron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Steiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,2]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/028418600750013465"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1976.00780170034002"},{"key":"e_1_2_7_4_2","first-page":"892","article-title":"Preservation of laryngeal function in treatment of hypopharyngeal carcinoma.","volume":"115","author":"Wang T","year":"2002","journal-title":"Chin Med J (Engl)"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.128.4.384"},{"key":"e_1_2_7_6_2","first-page":"108","article-title":"[Combination treatment of hypopharyngeal cancer using endoscopic laser surgery and radiation follow\u2010up.]","volume":"81","author":"Steiner W","year":"1987","journal-title":"Sonderb Strahlenther Onkol"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10363"},{"key":"e_1_2_7_8_2","volume-title":"Endoscopic Laser Surgery of the Upper Aerodigestive Tract","author":"Steiner W","year":"2000"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2001.111598"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200205000-00011"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199312000-00010"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20074"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199705000-00017"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200012000-00019"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200003000-00015"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.05.027"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200106000-00028"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1097%2FMLG.0b013e31815aeda3","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/MLG.0b013e31815aeda3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T09:36:30Z","timestamp":1696930590000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/MLG.0b013e31815aeda3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["10.1097\/MLG.0b013e31815aeda3"],"URL":"https:\/\/doi.org\/10.1097\/mlg.0b013e31815aeda3","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3]]}}}