{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:55:15Z","timestamp":1760982915522},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,1,2]],"date-time":"2009-01-02T00:00:00Z","timestamp":1230854400000},"content-version":"vor","delay-in-days":307,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The use of earwax softeners and cerumenolytics to unblock the external auditory canal is increasing. Although reports on their effectiveness are available, data about their effect on hearing are limited.<\/jats:p><jats:p><jats:bold>Objective:<\/jats:bold> To assess the effect of ototopic triethanolamine polypeptide oleate condensate 10% (Cerumenex) on hearing.<\/jats:p><jats:p><jats:bold>Study Design:<\/jats:bold> Prospective, randomized, controlled trial in a chinchilla animal model.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Tympanostomy tubes were inserted in five chinchillas, and hearing was assessed with distortion product otoacoustic emissions (DPOAE) between 1 and 9 kHz prior to application and at days 1, 4, 30, and 100 postototopic application of Cerumenex. One ear received Cerumenex; the other ear served as control. Postmortem scanning electron microscopy was performed to assess the cochlear hair cells.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> A reduction in the mean DPOAE signal was shown in the ears treated with Cerumenex from the first day after treatment and throughout the study. Almost all tested frequencies were affected. Swelling, crusting, and fluid were observed in four of the five experimental ears. One animal also developed facial paralysis in the experimental side. Electron microscopy showed damage of the outer and inner hair cells in the Cerumenex\u2010treated ears.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> In the chinchilla, when a tympanic perforation is present, Cerumenex causes a reduction in DPOAE signal and damage to the cochlear hair cells. Caution should be observed when prescribing this agent if the status of the tympanic membrane is unknown. Furthermore, its use without medical prescription should be discouraged because of the risk of ototoxicity and severe inflammatory reaction.<\/jats:p>","DOI":"10.1097\/mlg.0b013e31815d8e41","type":"journal-article","created":{"date-parts":[[2009,2,19]],"date-time":"2009-02-19T20:51:32Z","timestamp":1235076692000},"page":"478-482","source":"Crossref","is-referenced-by-count":9,"title":["Ototoxicity of Triethanolamine Polypeptide (Cerumenex) in the Chinchilla"],"prefix":"10.1002","volume":"118","author":[{"given":"Sam Joseph","family":"Daniel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia Isabel","family":"Sahmkow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymundo","family":"Munguia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melvin","family":"Schloss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fadi","family":"Akache","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,2]]},"reference":[{"key":"e_1_2_6_2_2","unstructured":"The Purdue Frederick Company.Cerumenex eardrops (triethanolamine polypeptide oleate\u2010condensate). U.S. Food and Drug Administration Center for Drug Evaluation and Research Website November 13 2001. Available at:http:\/\/www.fda.gov\/cder\/foi\/label\/2002\/11340s16lbl.pdf. Accessed January 31 2006."},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.2002.00614.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200310000-00019"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2004.09.008"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(02)00280-0"},{"key":"e_1_2_6_7_2","first-page":"121","article-title":"Middle ear instillation of gentamicin and streptomycin in chinchillas: morphologic appraisal of selective ototoxicity.","volume":"28","author":"Chen JM","year":"1999","journal-title":"J Otolaryngol"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.2310\/7070.2001.20001"},{"key":"e_1_2_6_9_2","first-page":"541","article-title":"Cerumen removal\u2010current challenges.","volume":"77","author":"Grossan M","year":"1998","journal-title":"ENT J"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1067\/mem.2000.109166"},{"key":"e_1_2_6_11_2","first-page":"87","article-title":"Safety and efficacy of Sofenz ceruminolytic solution.","volume":"85","author":"Midani A","year":"2006","journal-title":"ENT J"},{"key":"e_1_2_6_12_2","first-page":"906","article-title":"Effectiveness of ear syringing in general practice: a randomised controlled trial and patients' experiences.","volume":"52","author":"Memel D","year":"2002","journal-title":"Br J Gen Pract"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.130.10.1175"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.157.12.1177"},{"key":"e_1_2_6_15_2","first-page":"635","article-title":"A quasi\u2010randomised controlled trial of water as a quick softening agent of persistent earwax in general practice.","volume":"51","author":"Eekhof JA","year":"2001","journal-title":"Br J Gen Pract"},{"key":"e_1_2_6_16_2","first-page":"303","article-title":"Water as a fast acting wax softening agent before ear syringing.","volume":"34","author":"Pavlidis C","year":"2005","journal-title":"Aust Fam Physician"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.12968\/bjcn.2002.7.2.9208"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.5326\/15473317-33-6-479"},{"key":"e_1_2_6_19_2","unstructured":"CampbellK MullinG.Otoacoustic emissions. eMedicine Website July 27 2002. Available at:http:\/\/www.emedicine.com\/ent\/topic372.htm. Accessed February 14 2006."},{"key":"e_1_2_6_20_2","unstructured":"KalkanisJ GlatzF.Inner ear ototoxicity. eMedicine Website August 14 2004. Available at:http:\/\/www.emedicine.com\/ent\/topic699.htm. Accessed February 7 2006."}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1097%2FMLG.0b013e31815d8e41","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/MLG.0b013e31815d8e41","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T09:38:48Z","timestamp":1696930728000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/MLG.0b013e31815d8e41"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["10.1097\/MLG.0b013e31815d8e41"],"URL":"https:\/\/doi.org\/10.1097\/mlg.0b013e31815d8e41","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3]]}}}