{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T14:14:13Z","timestamp":1785248053281,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,1,2]],"date-time":"2009-01-02T00:00:00Z","timestamp":1230854400000},"content-version":"vor","delay-in-days":246,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objective:<\/jats:bold> M\u00e9ni\u00e8re's disease is a common inner ear disease with an incidence of 15 to 50 per 100,000 population. Since M\u00e9ni\u00e8re's disease is thought to be triggered by an immune insult to the inner ear, we examined intraendolymphatic sac application of steroids as a new therapeutic strategy for intractable M\u00e9ni\u00e8re's disease.<\/jats:p><jats:p><jats:bold>Study Design:<\/jats:bold> Prospective randomized controlled study.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Between 1996 and 2005, we enrolled and assigned 197 intractable M\u00e9ni\u00e8re's patients to three groups in a randomized controlled trial: Group I (G\u2010I)\u2014 patients who underwent endolymphatic sac drainage and steroid\u2010instillation; Group II (G\u2010II)\u2014those who underwent endolymphatic sac drainage without steroid\u2010instillation; and Group III (G\u2010III)\u2014those who declined endolymphatic sac drainage. Definitive spells and hearing in all three groups were determined for 2 to 7 years after treatment.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> According to the 1995 American Academy of Otolaryngology\u2013Head and Neck Surgery (AAO\u2010HNS) criteria, 2\u2010year results demonstrated that vertigo was completely controlled in 88.0% of patients in G\u2010I (n = 100), 85.1% of patients in G\u2010II (n = 47), and 8.0% in G\u2010III (n = 50). Statistically, G\u2010I = G\u2010II&gt;G\u2010III. Hearing was improved in 49.0% of patients in G\u2010I, 31.9% in G\u2010II, and 6.0% in G\u2010III (G\u2010I&gt;G\u2010II&gt;G\u2010III). Results after 7 years showed that vertigo was completely controlled in 78.8% of patients in G\u2010I, 79.2% in G\u2010II, and 25.0% in G\u2010III (G\u2010I = G\u2010II&gt;G\u2010III). Hearing improved in 36.5% of patients in G\u2010I, 8.3% in G\u2010II, and 0.0% in G\u2010III (G\u2010I&gt;G\u2010II = G\u2010III).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> From non\u2010surgical observation in G\u2010III for at least 7 years after treatment, steroids instilled into endolymphatic sac in G\u2010I patients significantly improved hearing in intractable M\u00e9ni\u00e8re's patients, more so than endolymphatic sac drainage without steroids in G\u2010II patients.<\/jats:p>","DOI":"10.1097\/mlg.0b013e3181651c4a","type":"journal-article","created":{"date-parts":[[2008,4,23]],"date-time":"2008-04-23T10:56:49Z","timestamp":1208948209000},"page":"854-861","source":"Crossref","is-referenced-by-count":72,"title":["Effects of Endolymphatic Sac Drainage With Steroids for Intractable M\u00e9ni\u00e8re's Disease: A Long\u2010Term Follow\u2010Up and Randomized Controlled Study"],"prefix":"10.1002","volume":"118","author":[{"given":"Tadashi","family":"Kitahara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Kubo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin\u2010ichi","family":"Okumura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Kitahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,2]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1978.00790020041009"},{"key":"e_1_2_7_3_2","first-page":"2310","article-title":"Uber die pathologische Veranderung bei einem Meniere\u2010Kranken.","volume":"44","author":"Yamakawa K","year":"1938","journal-title":"J Otolaryngol Jpn"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100003947"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199412000-00012"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1969.00770020818006"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1986.03780050060010"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.1983.93.4.410"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198404000-00014"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199303000-00014"},{"key":"e_1_2_7_11_2","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/S0030-6665(20)30147-X","article-title":"The role of dexamethasone or streptomycin perfusion in the treatment of M\u00e9ni\u00e8re's disease.","volume":"30","author":"Shea JJ","year":"1997","journal-title":"Otolaryngol Clin North Am"},{"key":"e_1_2_7_12_2","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1067\/mhn.2001.119485","article-title":"Intratympanic dexamethasone, intratympanic gentamicin, and endolymphatic sac surgery for intractable vertigo in M\u00e9ni\u00e8re's disease.","volume":"125","author":"Sennarouglu L","year":"2001","journal-title":"Otolaryngol Head Neck Surg"},{"key":"e_1_2_7_13_2","first-page":"196","article-title":"Dexamethasone inner ear perfusion for the treatment of M\u00e9ni\u00e8re's disease: a prospective, randomized, double blind, crossover trial.","volume":"19","author":"Silverstein H","year":"1998","journal-title":"Am J Otol"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016488209130870"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949110000502"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1089\/10430349950018526"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1179\/016164103771953989"},{"key":"e_1_2_7_18_2","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0194-5998(95)70102-8","article-title":"Committee on Hearing and Equilibrium guidelines for diagnosis and evaluation of therapy in M\u00e9ni\u00e8re's disease","volume":"113","author":"Committee on Hearing and Equilibrium","year":"1995","journal-title":"Otolaryngol Head Neck Surg"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.3109\/01050398509045943"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1080\/000164800750044461"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348940111000203"},{"key":"e_1_2_7_22_2","unstructured":"KitaharaM GotoE.Sac expanding surgery for M\u00e9ni\u00e8re's disease. 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