{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:19:52Z","timestamp":1790986792580,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,1,2]],"date-time":"2009-01-02T00:00:00Z","timestamp":1230854400000},"content-version":"vor","delay-in-days":215,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objective:<\/jats:bold> Determine staging and comparative survival for nonsquamous cell carcinoma (SCC) of the larynx.<\/jats:p><jats:p><jats:bold>Study Design:<\/jats:bold> Cross\u2010sectional population analysis.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Cases of non\u2010SCC supraglottic, glottic, and subglottic cancers were extracted from the Surveillance, Epidemiology and End Results database (1988\u20132003) and the staging distribution computed. For each site, Kaplan\u2010Meier survivals were compared according to histology, T\u2010stage, and N\u2010stage. Survival for non\u2010SCC cancers for each site were compared among histologies, T\u2010stage, and N\u2010stage as well as with age\/sex\/stage\u2010matched SCC cancers to determine differences in survival.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> One hundred forty supraglottic non\u2010SCC cases were identified (67% male, mean age 62.0 yr) consisting of 25 neuroendocrine, 25 small cell, and 22 lymphomas (among others), with mean survivals of 44.8, 52.1, and 80.5 months, respectively. Survival was not significantly different according to histology (log\u2010rank, <jats:italic>P<\/jats:italic> = .440) but was significantly different according to T\u2010stage (<jats:italic>P<\/jats:italic> = .029) and N\u2010stage (<jats:italic>P<\/jats:italic> &lt; .001). Seventy\u2010eight glottic non\u2010SCC cases were identified (83% male, mean age 66.1 yr) consisting of 32 spindle cell, 13 sarcoma, and 10 small cell (among others), with mean survivals of 114.6, 89.8, and 39.2 months, respectively. Survival was not significantly different according to histology (<jats:italic>P<\/jats:italic> = .056) but was significantly different according to T\u2010stage (<jats:italic>P<\/jats:italic> = .002) and N\u2010stage (<jats:italic>P<\/jats:italic> = .022). Small numbers (26) precluded subglottic analysis. For both supraglottic and glottic sites including all histologies, survival was similar for matched non\u2010SCC and SCC cases (<jats:italic>P<\/jats:italic> = .510 and <jats:italic>P<\/jats:italic> = .930, respectively).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Non\u2010SCCs are more common in the supraglottic larynx. T\u2010stage and N\u2010stage influence survival more than histology alone for these cancers.<\/jats:p>","DOI":"10.1097\/mlg.0b013e3181671b3d","type":"journal-article","created":{"date-parts":[[2008,5,28]],"date-time":"2008-05-28T13:51:02Z","timestamp":1211982662000},"page":"1003-1013","source":"Crossref","is-referenced-by-count":58,"title":["Staging and Survival Analysis for Nonsquamous Cell Carcinomas of the Larynx"],"prefix":"10.1002","volume":"118","author":[{"given":"Harrison W.","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Bhattacharyya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,2]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.55.2.74"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2006.07.002"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348940611500806"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e318033c800"},{"key":"e_1_2_6_6_2","unstructured":"Surveillance Epidemiology and End Results (SEER) Program(www.seer.cancer.gov). SEER*Stat Database: Incidence SEER 17 Regs Public\u2010Use Nov 2005 Sub (1973\u20102003 varying). National Cancer Institute DCCPS Surveillance Research Program Cancer Statistics Branch. Released April 2006 based on the November 2005 submission. 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