{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T10:26:28Z","timestamp":1756463188652},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,1,2]],"date-time":"2009-01-02T00:00:00Z","timestamp":1230854400000},"content-version":"vor","delay-in-days":215,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objectives:<\/jats:bold> There are many studies that have examined functional outcomes following Gamma Knife treatment; however, few have reported long\u2010term audiometric data. This study analyzed the long\u2010term hearing results of Gamma Knife radiosurgery in the treatment of acoustic neuromas.<\/jats:p><jats:p><jats:bold>Study Design:<\/jats:bold> Retrospective cohort study.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Seventeen patients were selected from our acoustic neuroma Gamma Knife registry of 113 patients treated from 1991 to 2005. Pretreatment audiograms were analyzed for pure\u2010tone average and word recognition scores and assigned a Gardner\u2010Robertson classification score (GRC). Either a current audiogram was obtained or the most recent audiogram (if the patient was lost to follow\u2010up) was reviewed from clinic charts and these were compared with the preoperative results. Audiometric data of the pre\u2010 and posttreatment normal ear were obtained and used as the patient's own control.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The tumor size ranged from 0.5 to 2.8 cm (mean, 1.33 cm) and patients received a range of 12.5\u201316 Gy (mean, 13.82 Gy) to 50% isodose line. Patient follow\u2010up ranged from 3 to 82 months with a mean of 33.6 months. Pretreatment pure\u2010tone average for the involved side group was 30.6 dB HL with a word recognition score of 74%. Pretreatment mean GRC was 1.76. posttreatment pure\u2010tone average for the group was 59.7 dB HL with a word recognition score of 37%. posttreatment mean GRC was 3.29. Comparing pre\u2010 versus post\u2010Gamma Knife radiosurgery results on the treatment ear, means were statistically significantly different for both pure\u2010tone average and word recognition scores, based on a paired\u2010samples <jats:italic>t<\/jats:italic> test (<jats:italic>P<\/jats:italic> &lt; .001 for both). The group \u201cnormal\u201d ear pure\u2010tone average was 14 dB HL and 17.75 dB HL pre\u2010 and posttreat\u2010ment, respectively. Normal ear pre\u2010 and posttreatment word recognition score and GRC were 93% and 98%, and 1.13 and 1.31, respectively.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Gamma Knife radiosurgery remains a noninvasive treatment option for patients with acoustic neuromas; however, they may experience a delayed hearing loss. Of those patients with useful audition pretreatment, 42% maintained useful hearing posttreatment.<\/jats:p>","DOI":"10.1097\/mlg.0b013e31816b8cc7","type":"journal-article","created":{"date-parts":[[2008,5,28]],"date-time":"2008-05-28T13:51:02Z","timestamp":1211982662000},"page":"1019-1022","source":"Crossref","is-referenced-by-count":15,"title":["Long\u2010Term Hearing Results in Gamma Knife Radiosurgery for Acoustic Neuromas"],"prefix":"10.1002","volume":"118","author":[{"given":"Matthew L.","family":"Bush","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer B.","family":"Shinn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A Byron","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raleigh O.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,2]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"316","article-title":"Stereotactic method of radiotherapy for brain.","volume":"201","author":"Leksell L","year":"1951","journal-title":"Acta Chir Scand"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000056409"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000166542.00512.84"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2005.102.s_supplement.0204"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199811123392003"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000073416.22608.B3"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348948809700110"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200409000-00018"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200011000-00016"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1995.00540250077016"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-8140(93)90127-T"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.01.001"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1097%2FMLG.0b013e31816b8cc7","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/MLG.0b013e31816b8cc7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T13:38:57Z","timestamp":1700055537000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/MLG.0b013e31816b8cc7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["10.1097\/MLG.0b013e31816b8cc7"],"URL":"https:\/\/doi.org\/10.1097\/mlg.0b013e31816b8cc7","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6]]}}}