{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T19:03:56Z","timestamp":1774119836156,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,1,2]],"date-time":"2009-01-02T00:00:00Z","timestamp":1230854400000},"content-version":"vor","delay-in-days":185,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objectives\/Hypothesis:<\/jats:bold> Aspirin\u2010sensitivity, asthma, and nasal polyposis (NP) comprise the clinical entity of Samter's triad. The aim of this study is to report the sinonasal outcomes of endoscopic sinus surgery (ESS) in treating NP in asthmatic patients, comparing aspirin\u2010induced asthmatic (AIA) patients with aspirin\u2010tolerant asthmatics (ATA).<\/jats:p><jats:p><jats:bold>Study Design:<\/jats:bold> Retrospective chart review.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The records of 66 patients with NP and asthma were retrospectively reviewed. Forty\u2010one AIA patients were compared with 25 ATA patients. For each patient, a Lund\u2010Mackay computed tomography (CT) score of the preoperative scans and the available postoperative CT scans in a period of 18 months were calculated and used as primary endpoint. Sinonasal improvement assessed by patients and reported with a symptoms scale was used as the secondary endpoint for the comparison immediately before surgery and 6 months and 12 months following ESS.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Preoperative CT scores in AIA patients compared with ATA patients were significantly higher 19 (standard deviation, 4.82) vs. 14 (standard deviation, 6.8), respectively (<jats:italic>P<\/jats:italic> = .006). This difference was sustained for the available postoperative CT scans (<jats:italic>P<\/jats:italic> &lt; .0001). During the period of 18 months follow\u2010up, 63.4% of AIA patients vs. 96% of ATA patients had CT improvement with a statistically significant difference between the two groups (<jats:italic>P<\/jats:italic> = .003). At 6 months following ESS, 63.4% of AIA patients vs. 56% of ATA patients had symptomatic improvement. At 12 months, 68.3% of AIA patients vs. 60% of ATA patients had symptomatic improvement, with no significant difference between the two groups.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> AIA patients had more extensive sinonasal disease than ATA patients. Both groups showed statistically significant improvement in sinonasal outcomes after ESS. The difference between the two groups was statistically significant for patients' CT improvement with worse CT scores being seen in AIA patients.<\/jats:p>","DOI":"10.1097\/mlg.0b013e318170af1e","type":"journal-article","created":{"date-parts":[[2009,2,19]],"date-time":"2009-02-19T21:32:47Z","timestamp":1235079167000},"page":"1282-1286","source":"Crossref","is-referenced-by-count":61,"title":["Sinonasal Outcomes After Endoscopic Sinus Surgery in Asthmatic Patients With Nasal Polyps: A Difference Between Aspirin\u2010Tolerant and Aspirin\u2010Induced Asthma?"],"prefix":"10.1002","volume":"118","author":[{"given":"Osama G.","family":"Awad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John H.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Beth","family":"Fasano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott M.","family":"Graham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,2]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1258\/0022215021910492"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-198708090-00017"},{"key":"e_1_2_6_4_2","first-page":"297","article-title":"First complete description of the aspirin idiosyncrasy\u2010asthma\u2010nasal polyposis syndromes.","volume":"24","author":"Widal F","year":"1987","journal-title":"J Asthma"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-68-5-975"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(79)90059-9"},{"key":"e_1_2_6_7_2","first-page":"283","volume-title":"Biochemistry of Lipids, Lipoproteins, and Membranes","author":"Smith WL","year":"1991"},{"key":"e_1_2_6_8_2","doi-asserted-by":"crossref","unstructured":"AwadOG FasanoMB LeeJH GrahamSM.Asthma outcomes after endoscopic sinus surgery in aspirin\u2010tolerant versus aspirin\u2010induced asthmatics. 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