{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:27:26Z","timestamp":1787315246859,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,1,2]],"date-time":"2009-01-02T00:00:00Z","timestamp":1230854400000},"content-version":"vor","delay-in-days":185,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objectives\/Hypothesis:<\/jats:bold>\n                    To describe the utility of a large transnasal craniotomy and its reconstruction in the surgical management of patients with craniopharyngioma.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Study Design:<\/jats:bold>\n                    Observational retrospective cohort study.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Retrospective review of patients treated in an academic neurosurgery\/rhinology practice between 2000 and 2007. Patient characteristics (age, sex, follow\u2010up), tumor factors (size, position extension, previous surgery), type of repair (pedicled mucosal flaps, free mucosal grafts), and outcomes (visual, endocrine, and surgical morbidity) were defined and sought in patients who had an entirely endoscopic resection of extensive craniopharyngioma (defined as requiring removal of the planum sphenoidale in addition to sella exposure in the approach).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Seven patients had an entirely endoscopic resection of extensive craniopharyngioma during the study period. Mean age was 23.4 years (standard deviation \u00b1 16.3). Mean tumor size was 3.2 cm (standard deviation \u00b1 2.0). The majority of these pathologies had extensive suprasellar disease, and two (28.6%) had ventricular disease. Cerebrospinal fluid leak rate was 29% (2 of 7). These leaks occurred only in reconstructions with free mucosal grafts. There were no cerebrospinal fluid leaks in patients who had vascularized pedicled septal flap repairs.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    The endoscopic management of large craniopharyngioma emphasizes recent advancements in endoscopic skull base surgery. The ability to provide exposure through a large (4 cm+) transnasal craniotomy, near\u2010field assessment of neurovascular structures, and the successful reconstruction of a large skull defect have significantly advanced the field in the past decade. The use of a two\u2010surgeon approach and bilateral pedicled septal mucosal flaps have greatly enhanced the reliability of this approach.\n                  <\/jats:p>","DOI":"10.1097\/mlg.0b013e318170b5dc","type":"journal-article","created":{"date-parts":[[2009,2,19]],"date-time":"2009-02-19T16:28:17Z","timestamp":1235060897000},"page":"1142-1148","source":"Crossref","is-referenced-by-count":63,"title":["Endoscopic Transnasal Craniotomy and the Resection of Craniopharyngioma"],"prefix":"10.1002","volume":"118","author":[{"given":"Aldo C.","family":"Stamm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Vellutini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard John","family":"Harvey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Jo\u00e3o Fl\u00e1vio","family":"Nogeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego R.","family":"Herman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,2]]},"reference":[{"key":"e_1_2_6_2_2","volume-title":"Principles and Practice of Neuropathology","author":"Nelson JS","year":"1993"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000150681.68355.85"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/194589240501900212"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2005.02231.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000091570"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000134287.19377.A2"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2004.100.3.0445"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2006.104.3.419"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1990.73.1.0003"},{"key":"e_1_2_6_11_2","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1177\/00034894061150S908","article-title":"Transnasal endoscopy\u2010assisted skull base surgery.","volume":"196","author":"Stamm AC","year":"2006","journal-title":"Ann Otol Rhinol Laryngol Suppl"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/019459989310900108"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2006.01.011"},{"key":"e_1_2_6_14_2","first-page":"E7","article-title":"Endoneurosurgical hemostasis techniques: lessons learned from 400 cases.","volume":"19","author":"Kassam A","year":"2005","journal-title":"Neurosurg"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000219897.98238.A3"},{"issue":"1","key":"e_1_2_6_16_2","first-page":"447","article-title":"A multimodality approach to the treatment of craniopharyngiomas avoiding hypothalamic morbidity: a UK perspective.","volume":"19","author":"Spoudeas HA","year":"2006","journal-title":"J Pediatr Endocrinol"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000219914.17221.55"},{"issue":"1","key":"e_1_2_6_18_2","first-page":"3","article-title":"Pediatric craniopharyngiomas: classification and treatment according to the degree of hypothalamic involvement. [see comment].","volume":"106","author":"Puget S","year":"2007","journal-title":"J Neurosurg"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000234933.37779.e4"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2004.tb00476.x"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000249211.89096.25"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2007.106.3.400"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000219897.98238.A3"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2005.09.014"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-830185"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1997.87.1.0044"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-36197"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2003.98.2.0350"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2005.102.4.0650"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2005.102.5.0832"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2005.102.5.0825"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1097%2FMLG.0b013e318170b5dc","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/MLG.0b013e318170b5dc","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T05:48:05Z","timestamp":1696830485000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/MLG.0b013e318170b5dc"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7]]},"references-count":30,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["10.1097\/MLG.0b013e318170b5dc"],"URL":"https:\/\/doi.org\/10.1097\/mlg.0b013e318170b5dc","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7]]}}}