{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:17:42Z","timestamp":1792196262575,"version":"4.4.0"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2009,1,2]],"date-time":"2009-01-02T00:00:00Z","timestamp":1230854400000},"content-version":"vor","delay-in-days":154,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objectives\/Hypothesis:<\/jats:bold> The use of self\u2010expanding metallic airway stents has been extended in recent years in inoperable patients with malignant and benign airway diseases. The risk of granulation tissue formation in the stent is a major concern. The objective of the present study was to determine whether immunosuppression modulates granulation tissue formation in airway stents, as seen in coronary stents.<\/jats:p><jats:p><jats:bold>Study Design:<\/jats:bold> The study included 19 patients with benign airway obstructions and 11 recipients of lung transplants with anastomotic obstructions who were receiving immunosuppression therapy.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The degree of in\u2010stent granulation tissue formation was evaluated (score range, 0\u20133) every 3 months for 2 years.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Granulation tissue formation was significantly lower in the transplant recipients than in the nontransplant patients at 3 months (score 0.7 vs. 1.6, <jats:italic>P<\/jats:italic> = .031), 15 months (score 0 vs. 1.1, <jats:italic>P<\/jats:italic> = .026), and 18 months (score 0 vs. 1.8, <jats:italic>P<\/jats:italic> = .020). During the 2 years of follow\u2010up, the transplant recipients underwent significantly fewer laser resections and brachytherapy treatments for in\u2010stent granulation.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> The immunosuppression given to lung transplant recipients may have an inhibitory effect on granulation tissue formation in metallic airway stents. Further studies are needed to evaluate the effect of systemic therapy or coated stents with drugs such as sirolimus.<\/jats:p>","DOI":"10.1097\/mlg.0b013e318172d686","type":"journal-article","created":{"date-parts":[[2009,2,19]],"date-time":"2009-02-19T21:24:16Z","timestamp":1235078656000},"page":"1383-1388","source":"Crossref","is-referenced-by-count":25,"title":["Protective Effect of Immunosuppression on Granulation Tissue Formation in Metallic Airway Stents"],"prefix":"10.1002","volume":"118","author":[{"given":"Dekel","family":"Shlomi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nir","family":"Peled","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Shitrit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Bendayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anat","family":"Amital","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mordechai R.","family":"Kramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,2]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"841","article-title":"Airway stenting.","volume":"11","author":"Wood DE","year":"2001","journal-title":"Chest Surg Clin North Am"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(97)83852-0"},{"key":"e_1_2_6_4_2","first-page":"295","article-title":"Pulmonary transplantation. Early and late results. The Toronto Lung Transplant Group.","volume":"103","author":"de Hoyos AL","year":"1992","journal-title":"J Thorac Cardiovasc Surg"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(96)80418-0"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.97.10122872"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(01)00619-4"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200410-1388OC"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348940211100401"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.120.6.1894"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035071"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000156334.24955.B2"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.56.5.415"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(99)00117-5"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(03)00466-1"},{"key":"e_1_2_6_16_2","first-page":"659","article-title":"Drug\u2010eluting stents versus repeat vascular brachytherapy for patients with recurrent in\u2010stent restenosis after failed intracoronary radiation.","volume":"17","author":"Chu WW","year":"2005","journal-title":"J Invasive Cardiol"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.124.5.1993"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(03)00333-3"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.20332"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000138935.17503.35"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2004.050617"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2005.03.005"},{"key":"e_1_2_6_23_2","first-page":"484","article-title":"Different inhibitory effects of immunosuppressive drugs on human and rat aortic smooth muscle and endothelial cell proliferation stimulated by platelet\u2010derived growth factor or endothelial cell growth factor.","volume":"16","author":"Mohacsi PJ","year":"1997","journal-title":"J Heart Lung Transplant"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1A128"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(03)00309-7"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2004.07.062"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2005.07.057"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1097%2FMLG.0b013e318172d686","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/MLG.0b013e318172d686","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T09:40:18Z","timestamp":1696930818000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/MLG.0b013e318172d686"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":26,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["10.1097\/MLG.0b013e318172d686"],"URL":"https:\/\/doi.org\/10.1097\/mlg.0b013e318172d686","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8]]}}}