{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T12:02:38Z","timestamp":1773835358144,"version":"3.50.1"},"reference-count":58,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2009,1,2]],"date-time":"2009-01-02T00:00:00Z","timestamp":1230854400000},"content-version":"vor","delay-in-days":62,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Introduction:<\/jats:bold>Successful wound healing represents the coordinated response of cellular, cytokine, and growth factor mechanisms involved in tissue recovery. Disruptions in transforming growth factor\u2010\u03b2 signaling, senescence\/apoptosis, keratinocyte\u2010fibroblast interactions, and other regulatory cascades can lead to the production of hypertrophic scar or keloid tissue formation. Current clinical investigations support surgical excision, meticulous closure, postoperative steroid injections, and postprocedural pressure dressings in the treatment of keloid tissue formation. Unfortunately, a universal approach in keloid therapy has yet to be identified. Here we offer a novel banding technique using suture ligature for the removal of these tissues.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold>Using a suture ligature, keloid tissues were banded along their base for a 5\u2010week period. Tissue evaluation and additional suture banding was performed on a weekly basis until complete mummification and spontaneous removal of ligated tissues. No additional pressure dressings were placed after tissue removal as treated sites had essentially undergone pressure therapy from the banding treatment.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold>Keloid tissues from multiple sites of the head and neck were effectively removed without complication using the suture banding technique. During a follow\u2010up period of 12 months, no evidence of keloid tissue recurrence was observed.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold>Keloid tissue formation remains a formidable challenge for the patient and physician alike. The application of a simple tissue banding technique holds promise in the direct and preventative treatment of keloid tissue formation whereas the end results merit further clinical and laboratory investigation.<\/jats:p>","DOI":"10.1097\/mlg.0b013e3181817b61","type":"journal-article","created":{"date-parts":[[2008,10,22]],"date-time":"2008-10-22T07:09:03Z","timestamp":1224659343000},"page":"1960-1965","source":"Crossref","is-referenced-by-count":4,"title":["Keloid Banding Using Suture Ligature: A Novel Technique and Review of Literature"],"prefix":"10.1002","volume":"118","author":[{"given":"Dhavan A.","family":"Parikh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James M.","family":"Ridgway","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norman N.","family":"Ge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,2]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S1064-7406(23)00309-7","article-title":"Wound healing in relation to scarring","volume":"6","author":"Hom DB","year":"1998","journal-title":"Facial Plast Surg North Am"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(81)70048-3"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.127.9.1140"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000195073.73580.46"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1929.02700270046011"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1078\/0344-0338-00447"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-197007000-00002"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200208000-00031"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.22327.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0007-1226(90)90047-4"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0738-081X(94)90254-2"},{"key":"e_1_2_5_13_2","doi-asserted-by":"crossref","first-page":"102","DOI":"10.2340\/0001555575102104","article-title":"Proliferating activity of dermal fibroblasts in keloids and hypertrophic scars","volume":"75","author":"Nakaoka H","year":"1995","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198911000-00021"},{"key":"e_1_2_5_15_2","first-page":"105","article-title":"Morphological and immunochemical differences between keloid and hypertrophic scar","volume":"145","author":"Ehrlich HP","year":"1994","journal-title":"Am J Pathol"},{"key":"e_1_2_5_16_2","first-page":"65","article-title":"Histological basis of keloid and hypertrophic scar differentiation: clinicopathologic correlation","volume":"82","author":"Blackburn WR","year":"1996","journal-title":"Arch Pathol"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1067-1927.2004.012209.x"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sap.0000164538.72375.93"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.2.587"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12396856"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64803-1"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2007.0591"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203656"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-123-31396"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/274052a0"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1747.2003.12572.x"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.137.11.1429"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(18)30653-3"},{"key":"e_1_2_5_29_2","first-page":"1375","article-title":"Platelet\u2010derived growth factor (BB homodimer), transforming growth factor\u2010beta 1, and basic fibroblast growth factor in dermal wound healing. 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