{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T01:45:45Z","timestamp":1715996745166},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2009,1,2]],"date-time":"2009-01-02T00:00:00Z","timestamp":1230854400000},"content-version":"vor","delay-in-days":32,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objectives\/Hypothesis:<\/jats:bold> In previous studies, we have demonstrated that the T\u2010allele of a specific single nucleotide polymorphism (SNP) in the G\u03b1s gene (T393C) correlates with increased G\u03b1s expression and hence apoptosis. The T\u2010allele was associated with a favorable outcome in a variety of human cancers, for example, carcinoma of the urinary bladder, kidney, colorectal, oro\u2010 and hypopharynx.<\/jats:p><jats:p><jats:bold>Study Design:<\/jats:bold> The prognostic value of the T393C SNP was retrospectively evaluated in an unselected series of patients treated with curative intent for laryngeal squamous cell carcinomas including all tumor stages with different therapeutic regimens.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> DNA analysis was performed using DNA from paraffin\u2010embedded tissue samples from 157 patients (142 men, 15 women) with a median follow\u2010up of 68 (3\u2013143) months. The various genotypes were correlated with the overall survival.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Survival was significantly dependent on the T393C genotype in advanced American Joint Committee on Cancer (AJCC) stages (III\u2013IV) with an apparent gene\u2010dose effect (<jats:italic>P<\/jats:italic> = .0437). Five\u2010year survival rates were 76% for TT, 49% for TC, and 43.5% for CC. In multivariate analysis including age at diagnosis, AJCC stage, grade, gender, and T393C genotypes, patients with CC genotype displayed a higher risk for death with a hazard ratio of 2.59 (95% confidence interval: 1.01\u20136.64, <jats:italic>P<\/jats:italic> = .047) compared with the reference group consisting of T393 homozygous individuals.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> The T393C SNP is a prognostic marker that could help to identify high risk patients suffering from head and neck cancer.<\/jats:p>","DOI":"10.1097\/mlg.0b013e318185793ds","type":"journal-article","created":{"date-parts":[[2008,11,19]],"date-time":"2008-11-19T08:10:55Z","timestamp":1227082255000},"page":"2172-2176","source":"Crossref","is-referenced-by-count":15,"title":["The <i>GNAS1<\/i> T393C Polymorphism Predicts Survival in Patients With Advanced Squamous Cell Carcinoma of the Larynx"],"prefix":"10.1002","volume":"118","author":[{"given":"Goetz F.","family":"Lehnerdt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Franz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Winterhoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnes","family":"Bankfalvi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Grehl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Lang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt W.","family":"Schmid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Winfried","family":"Siffert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Jahnke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich 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