{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T13:51:26Z","timestamp":1764078686382},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2009,1,2]],"date-time":"2009-01-02T00:00:00Z","timestamp":1230854400000},"content-version":"vor","delay-in-days":32,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Hypothesis:<\/jats:bold> To define the role of surgical staging in limited (T1\u20102, N0\u20101) oropharyngeal squamous cell cancers.<\/jats:p><jats:p><jats:bold>Study Design:<\/jats:bold> Retrospective.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Forty\u2010nine limited oropharyngeal squamous cell cancers of the tonsil, tongue base, or posterior pharyngeal wall\u2010treated surgically were identified.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Thirty\u2010five percent were cT1 and 65% were cT2 tumors although 58% were cN0 and 42% were cN1. Forty\u2010six patients underwent neck dissections. Surgical staging altered T\u2010stage in 26% (13\/49), nodal status in 23% (11\/46), and clinical staging in 40% (20\/49) of patients. Among 35 disease\u2010free patients, 28% (4\/20) of stage I\/II patients received postoperative radiation and chemotherapy was avoided in 80% (12\/15) of stage III patients. T1 tumors seemed to have better outcomes (<jats:italic>P<\/jats:italic> = .06). The 3 year disease\u2010free survival and 5 year overall survival was 85% and 83%, respectively.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Surgical staging identifies patients in whom intensification of treatment with chemotherapy can be most appropriately applied, and enables de\u2010intensification of therapy in pathology confirmed stage I\/II disease.<\/jats:p>","DOI":"10.1097\/mlg.0b013e3181857950","type":"journal-article","created":{"date-parts":[[2008,11,19]],"date-time":"2008-11-19T08:10:55Z","timestamp":1227082255000},"page":"2129-2134","source":"Crossref","is-referenced-by-count":65,"title":["Role of Surgery in Limited (T1\u20102, N0\u20101) Cancers of the Oropharynx"],"prefix":"10.1002","volume":"118","author":[{"given":"Rohan R.","family":"Walvekar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan J.","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William E.","family":"Gooding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael K.","family":"Gibson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dwight","family":"Heron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas T.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert L.","family":"Ferris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,2]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.14.1713"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22963"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2004.09.027"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20998"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.2002.00618.x"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016480500504259"},{"key":"e_1_2_7_8_2","unstructured":"National Comprehensive Cancer Network. 2007 NCCN Clinical Practice Guidelines in Oncology Head and Neck Cancers. 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