{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T22:20:35Z","timestamp":1791152435433,"version":"4.1.0"},"reference-count":50,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,7]]},"DOI":"10.1097\/mnh.0b013e32818b27bf","type":"journal-article","created":{"date-parts":[[2007,6,12]],"date-time":"2007-06-12T04:03:36Z","timestamp":1181621016000},"page":"348-352","source":"Crossref","is-referenced-by-count":30,"title":["Aquaporin-2 protein dynamics within the cell"],"prefix":"10.1097","volume":"16","author":[{"given":"Sei","family":"Sasaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumi","family":"Noda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-10-20210205","doi-asserted-by":"crossref","first-page":"F177","DOI":"10.1152\/ajprenal.00056.2005","article-title":"Posttranscriptional control of aquaporin-2 abundance by vasopressin in renal collecting duct principal cells","volume":"290","author":"Hasler","year":"2006","journal-title":"Am J Physiol Renal Physiol"},{"key":"R2-10-20210205","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.bbamem.2006.06.001","article-title":"cAMP regulates vasopressin-induced AQP2 expression via protein kinase A-independent pathway","volume":"1758","author":"Umenishi","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"R3-10-20210205","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1093\/ndt\/gfh677","article-title":"Hypertonicity regulates the aquaporin-2 promoter independently of arginine vasopressin","volume":"20","author":"Kasono","year":"2005","journal-title":"Nephrol Dial Transplant"},{"key":"R4-10-20210205","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1681\/ASN.2004110930","article-title":"Dual effects of hypertonicity on aquaporin-2 expression in cultured renal collecting duct principal cells","volume":"16","author":"Hasler","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"R5-10-20210205","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1159\/000096320","article-title":"Tonicity-dependent regulation of osmoprotective genes in mammalian cells","volume":"152","author":"Ferraris","year":"2006","journal-title":"Contrib Nephrol"},{"key":"R6-10-20210205","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1073\/pnas.0308703100","article-title":"Loss of NFAT5 results in renal atrophy and lack of tonicity-responsive gene expression","volume":"101","author":"Lopez-Rodriguez","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R7-10-20210205","doi-asserted-by":"crossref","first-page":"48048","DOI":"10.1074\/jbc.M407224200","article-title":"Osmotic response element-binding protein (OREBP) is an essential regulator of the urine concentrating mechanism","volume":"279","author":"Lam","year":"2004","journal-title":"J Biol Chem"},{"key":"R8-10-20210205","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1146\/annurev.cellbio.19.110701.161425","article-title":"Transport protein trafficking in polarized cells","volume":"19","author":"Muth","year":"2003","journal-title":"Annu Rev Cell Dev Biol"},{"key":"R9-10-20210205","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1046\/j.1523-1755.2003.00049.x","article-title":"Pathogenesis of nephrogenic diabetes insipidus by aquaporin-2 C-terminus mutations","volume":"64","author":"Asai","year":"2003","journal-title":"Kidney Int"},{"key":"R10-10-20210205","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1083\/jcb.200309017","article-title":"Reversed polarized delivery of an aquaporin-2 mutant causes dominant nephrogenic diabetes insipidus","volume":"163","author":"Kamsteeg","year":"2003","journal-title":"J Cell Biol"},{"key":"R11-10-20210205","doi-asserted-by":"crossref","first-page":"14217","DOI":"10.1073\/pnas.0602331103","article-title":"Pathogenesis and treatment of autosomal-dominant nephrogenic diabetes insipidus caused by an aquaporin 2 mutation","volume":"103","author":"Sohara","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R12-10-20210205","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1172\/JCI7453","article-title":"A PDZ-interacting domain in CFTR is an apical membrane polarization signal","volume":"104","author":"Moyer","year":"1999","journal-title":"J Clin Invest"},{"key":"R13-10-20210205","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/ng1082","article-title":"Nonpolarized targeting of AE1 causes autosomal dominant distal renal tubular acidosis","volume":"33","author":"Devonald","year":"2003","journal-title":"Nat Genet"},{"key":"R14-10-20210205","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1111\/j.1523-1755.2005.00654.x","article-title":"The C-terminal tail of aquaporin-2 determines apical trafficking","volume":"68","author":"Kuwahara","year":"2005","journal-title":"Kidney Int"},{"key":"R15-10-20210205","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.febslet.2004.05.021","article-title":"Aquaporin-2 trafficking is regulated by PDZ-domain containing protein SPA-1","volume":"568","author":"Noda","year":"2004","journal-title":"FEBS Lett"},{"key":"R16-10-20210205","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1074\/mcp.M500049-MCP200","article-title":"Large scale protein identification in intracellular aquaporin-2 vesicles from renal inner medullary collecting duct","volume":"4","author":"Barile","year":"2005","journal-title":"Mol Cell Proteomics"},{"key":"R17-10-20210205","doi-asserted-by":"crossref","first-page":"C757","DOI":"10.1152\/ajpcell.1993.265.3.C757","article-title":"Vasopressin depolymerizes apical F-actin in rat inner medullary collecting duct","volume":"265","author":"Simon","year":"1993","journal-title":"Am J Physiol"},{"key":"R18-10-20210205","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1242\/jcs.113.11.1985","article-title":"The phosphatase inhibitor okadaic acid induces AQP2 translocation independently from AQP2 phosphorylation in renal collecting duct cells","volume":"113","author":"Valenti","year":"2000","journal-title":"J Cell Sci"},{"key":"R19-10-20210205","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1242\/jcs.00355","article-title":"Valenti G. cAMP-induced AQP2 translocation is associated with RhoA inhibition through RhoA phosphorylation and interaction with RhoGDI","volume":"116","author":"Tamma","year":"2003","journal-title":"J Cell Sci"},{"key":"R20-10-20210205","doi-asserted-by":"crossref","first-page":"3623","DOI":"10.1242\/jcs.02495","article-title":"Actin remodeling requires ERM function to facilitate AQP2 apical targeting","volume":"118","author":"Tamma","year":"2006","journal-title":"J Cell Sci"},{"key":"R21-10-20210205","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.bbrc.2004.07.195","article-title":"Water channel aquaporin-2 directly binds to actin","volume":"322","author":"Noda","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"R22-10-20210205","doi-asserted-by":"crossref","first-page":"6952","DOI":"10.1073\/pnas.0602087103","article-title":"Congenital progressive hydronephrosis (cph) is caused by an S256L mutation in aquaporin-2 that affects its phosphorylation and apical membrane accumulation","volume":"103","author":"McDill","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R23-10-20210205","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.1681\/ASN.2005010104","article-title":"Lack of arginine vasopressin-induced phosphorylation of aquaporin-2 mutant AQP2-R254L explains dominant nephrogenic diabetes insipidus","volume":"16","author":"de Mattia","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"R24-10-20210205","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1152\/physrev.00021.2003","article-title":"Localized effects of cAMP mediated by distinct routes of protein kinase A","volume":"84","author":"Tasken","year":"2004","journal-title":"Physiol Rev"},{"key":"R25-10-20210205","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1042\/BST0331316","article-title":"Compartmentalized cAMP signalling regulates vasopressin-mediated water reabsorption by controlling aquaporin-2","volume":"33","author":"Henn","year":"2005","journal-title":"Biochem Soc Trans"},{"key":"R26-10-20210205","doi-asserted-by":"crossref","first-page":"26654","DOI":"10.1074\/jbc.M312835200","article-title":"Identification of a novel A-kinase anchoring protein 18 isoform and evidence for its role in the vasopressin-induced aquaporin-2 shuttle in renal principal cells","volume":"279","author":"Henn","year":"2004","journal-title":"J Biol Chem"},{"key":"R27-10-20210205","first-page":"F1103","article-title":"Stimulation of AQP2 membrane insertion in renal epithelial cells in vitro and in vivo by the cGMP phosphodiesterase inhibitor sildenafil citrate (Viagra)","volume":"288","author":"Bouley","year":"2005","journal-title":"Am J Physiol"},{"key":"R28-10-20210205","doi-asserted-by":"crossref","first-page":"7159","DOI":"10.1073\/pnas.0600895103","article-title":"Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites","volume":"103","author":"Hoffert","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R29-10-20210205","doi-asserted-by":"crossref","first-page":"36839","DOI":"10.1074\/jbc.M005552200","article-title":"Regulation of aquaporin-2 trafficking by vasopressin in the renal collecting duct: roles of ryanodine-sensitive Ca2+ stores and calmodulin","volume":"275","author":"Chou","year":"2000","journal-title":"J Biol Chem"},{"key":"R30-10-20210205","doi-asserted-by":"crossref","first-page":"F882","DOI":"10.1152\/ajprenal.00411.2005","article-title":"Epac-mediated Ca(2+) mobilization and exocytosis in inner medullary collecting duct","volume":"291","author":"Yip","year":"2006","journal-title":"Am J Physiol Renal Physiol"},{"key":"R31-10-20210205","doi-asserted-by":"crossref","first-page":"3667","DOI":"10.1242\/jcs.00053","article-title":"Functional involvement of VAMP\/synaptobrevin-2 in cAMP-stimulated aquaporin 2 translocation in renal collecting duct cells","volume":"115","author":"Gouraud","year":"2002","journal-title":"J Cell Sci"},{"key":"R32-10-20210205","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.bbamem.2006.03.004","article-title":"Regulation of aquaporin-2 trafficking and its binding protein complex","volume":"1758","author":"Noda","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"R33-10-20210205","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.molmed.2004.06.004","article-title":"Rap1 and SPA-1 in hematologic malignancy","volume":"10","author":"Kometani","year":"2004","journal-title":"Trends Mol Med"},{"key":"R34-10-20210205","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0896-6273(01)00355-5","article-title":"Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP","volume":"31","author":"Pak","year":"2001","journal-title":"Neuron"},{"key":"R35-10-20210205","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.imlet.2004.01.004","article-title":"Specific recruitment of SPA-1 to the immunological synapse: involvement of actin-bundling protein actinin","volume":"92","author":"Harazaki","year":"2004","journal-title":"Immunol Lett"},{"key":"R36-10-20210205","doi-asserted-by":"crossref","first-page":"F1113","DOI":"10.1152\/ajprenal.00195.2006","article-title":"Interaction of epithelial ion channels with the actin-based cytoskeleton","volume":"291","author":"Mazzochi","year":"2006","journal-title":"Am J Physiol Renal Physiol"},{"key":"R37-10-20210205","doi-asserted-by":"crossref","first-page":"6528","DOI":"10.1074\/jbc.M509386200","article-title":"The carboxyl terminus of the alpha-subunit of the amiloride-sensitive epithelial sodium channel binds to F-actin","volume":"281","author":"Mazzochi","year":"2006","journal-title":"J Biol Chem"},{"key":"R38-10-20210205","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.bbrc.2005.03.079","article-title":"Identification of a multiprotein \u2018motor\u2019 complex binding to water channel aquaporin-2","volume":"330","author":"Noda","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"R39-10-20210205","first-page":"F233","article-title":"Inhibition of endocytosis causes phosphorylation (S256)-independent plasma membrane accumulation of AQP2","volume":"286","author":"Lu","year":"2004","journal-title":"Am J Physiol"},{"key":"R40-10-20210205","doi-asserted-by":"crossref","first-page":"F246","DOI":"10.1152\/ajprenal.00437.2005","article-title":"Methyl-beta-cyclodextrin induces vasopressin-independent apical accumulation of aquaporin-2 in the isolated, perfused rat kidney","volume":"291","author":"Russo","year":"2006","journal-title":"Am J Physiol Renal Physiol"},{"key":"R41-10-20210205","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1042\/BC20040054","article-title":"Aquaporin 2 (AQP2) and vasopressin type 2 receptor (V2R) endocytosis in kidney epithelial cells: AQP2 is located in \u2018endocytosis-resistant\u2019 membrane domains after vasopressin treatment","volume":"98","author":"Bouley","year":"2006","journal-title":"Biol Cell"},{"key":"R42-10-20210205","doi-asserted-by":"crossref","first-page":"F930","DOI":"10.1152\/ajprenal.00291.2004","article-title":"Bidirectional regulation of AQP2 trafficking and recycling: involvement of AQP2-S256 phosphorylation","volume":"288","author":"Nejsum","year":"2005","journal-title":"Am J Physiol Renal Physiol"},{"key":"R43-10-20210205","doi-asserted-by":"crossref","first-page":"4375","DOI":"10.1210\/en.2004-0073","article-title":"Aquaporin-2 is retrieved to the apical storage compartment via early endosomes and phosphatidylinositol 3-kinase-dependent pathway","volume":"145","author":"Tajika","year":"2004","journal-title":"Endocrinology"},{"key":"R44-10-20210205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00418-005-0010-3","article-title":"Differential regulation of AQP2 trafficking in endosomes by microtubules and actin filaments","volume":"124","author":"Tajika","year":"2005","journal-title":"Histochem Cell Biol"},{"key":"R45-10-20210205","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1126\/science.1127085","article-title":"Proteasome-independent functions of ubiquitin in endocytosis and signaling","volume":"315","author":"Mukhopadhyay","year":"2007","journal-title":"Science"},{"key":"R46-10-20210205","doi-asserted-by":"crossref","first-page":"18344","DOI":"10.1073\/pnas.0604073103","article-title":"Short-chain ubiquitination mediates the regulated endocytosis of the aquaporin-2 water channel","volume":"103","author":"Kamsteeg","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R47-10-20210205","doi-asserted-by":"crossref","first-page":"13368","DOI":"10.1073\/pnas.0403453101","article-title":"Identification and proteomic profiling of exosomes in human urine","volume":"101","author":"Pisitkun","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R48-10-20210205","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/nri855","article-title":"Exosomes: composition, biogenesis and function","volume":"2","author":"Thery","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"R49-10-20210205","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1056\/NEJM199506083322303","article-title":"Urinary excretion of aquaporin-2 in patients with diabetes insipidus","volume":"332","author":"Kanno","year":"1995","journal-title":"N Engl J Med"},{"key":"R50-10-20210205","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1111\/j.1523-1755.2004.00902.x","article-title":"Urinary excretion of aquaporin-2 water channel exaggerated dependent upon vasopressin in congestive heart failure","volume":"66","author":"Funayama","year":"2004","journal-title":"Kidney Int"}],"container-title":["Current Opinion in Nephrology &amp; Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/MNH.0b013e32818b27bf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T16:43:07Z","timestamp":1786034587000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00041552-200707000-00010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007]]}},"URL":"https:\/\/doi.org\/10.1097\/mnh.0b013e32818b27bf","relation":{},"ISSN":["1062-4821"],"issn-type":[{"value":"1062-4821","type":"print"}],"subject":[],"published":{"date-parts":[[2007,7]]}}}