{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:49:37Z","timestamp":1791856177753,"version":"4.3.4"},"reference-count":54,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Opinion in Nephrology and Hypertension"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1097\/mnh.0b013e32834132bc","type":"journal-article","created":{"date-parts":[[2010,11,18]],"date-time":"2010-11-18T02:22:56Z","timestamp":1290046976000},"page":"16-22","source":"Crossref","is-referenced-by-count":34,"title":["SPAK and WNK kinases: a new target for blood pressure treatment?"],"prefix":"10.1097","volume":"20","author":[{"given":"Mark","family":"Glover","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin M","family":"O\u02bcShaughnessy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-4-20101208","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/sj.jhh.1001683","volume":"18","author":"Williams","year":"2004","journal-title":"J Hum Hypertens"},{"key":"R3-4-20101208","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nature05911","volume":"447","author":"","year":"2007","journal-title":"Nature"},{"key":"R4-4-20101208","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1146\/annurev.physiol.70.113006.100651","volume":"70","author":"Kahle","year":"2008","journal-title":"Annu Rev Physiol"},{"key":"R5-4-20101208","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00424-008-0595-1","volume":"458","author":"Bobulescu","year":"2009","journal-title":"Pflugers Arch"},{"key":"R6-4-20101208","first-page":"221","volume":"79","author":"Gitelman","year":"1966","journal-title":"Trans Assoc Am Physicians"},{"key":"R7-4-20101208","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/imj.1970.19.4.287","volume":"19","author":"Gordon","year":"1970","journal-title":"Australas Ann Med"},{"key":"R8-4-20101208","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/361467a0","volume":"361","author":"Canessa","year":"1993","journal-title":"Nature"},{"key":"R9-4-20101208","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/367463a0","volume":"367","author":"Canessa","year":"1994","journal-title":"Nature"},{"key":"R10-4-20101208","first-page":"199","volume":"76","author":"Liddle","year":"1963","journal-title":"Trans Assoc Am Physicians"},{"key":"R11-4-20101208","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1126\/science.289.5476.119","volume":"289","author":"Geller","year":"2000","journal-title":"Science"},{"key":"R12-4-20101208","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/ng0895-394","volume":"10","author":"Mune","year":"1995","journal-title":"Nat Genet"},{"key":"R13-4-20101208","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1177\/003693308603100114","volume":"31","author":"Gordon","year":"1986","journal-title":"Scott Med J"},{"key":"R14-4-20101208","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1445-5994.1986.tb01154.x","volume":"16","author":"Wayne","year":"1986","journal-title":"Aust N Z J Med"},{"key":"R15-4-20101208","first-page":"245","volume":"190","author":"Lee","year":"1979","journal-title":"Q J Med"},{"key":"R16-4-20101208","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1097\/00004872-200111000-00005","volume":"19","author":"Disse-Nicodeme","year":"2001","journal-title":"J Hypertens"},{"key":"R17-4-20101208","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1086\/303020","volume":"67","author":"Disse-Nicodeme","year":"2000","journal-title":"Am J Hum Genet"},{"key":"R18-4-20101208","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/ng0697-202","volume":"16","author":"Mansfield","year":"1997","journal-title":"Nat Genet"},{"key":"R19-4-20101208","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1007\/s00467-006-0321-1","volume":"22","author":"Riveira-Munoz","year":"2007","journal-title":"Pediatr Nephrol"},{"key":"R20-4-20101208","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1681\/ASN.2006101095","volume":"18","author":"Riveira-Munoz","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"R21-4-20101208","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.pharmthera.2004.11.010","volume":"106","author":"Cope","year":"2005","journal-title":"Pharmacol Ther"},{"key":"R22-4-20101208","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1681\/ASN.2008050542","volume":"20","author":"Glover","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"R23-4-20101208","doi-asserted-by":"crossref","first-page":"18471","DOI":"10.1074\/jbc.M109.008185","volume":"284","author":"Subramanya","year":"2009","journal-title":"J Biol Chem"},{"key":"R24-4-20101208","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1073\/pnas.242735399","volume":"100","author":"Wilson","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R25-4-20101208","doi-asserted-by":"crossref","first-page":"F1369","DOI":"10.1152\/ajprenal.00468.2005","volume":"291","author":"Golbang","year":"2006","journal-title":"Am J Physiol Renal Physiol"},{"key":"R26-4-20101208","doi-asserted-by":"crossref","first-page":"9208","DOI":"10.1128\/MCB.23.24.9208-9221.2003","volume":"23","author":"Delaloy","year":"2003","journal-title":"Mol Cell Biol"},{"key":"R27-4-20101208","doi-asserted-by":"crossref","first-page":"16777","DOI":"10.1073\/pnas.0508303102","volume":"102","author":"Rinehart","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R28-4-20101208","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2147\/TACG.S3536","volume":"1","author":"Qiao","year":"2008","journal-title":"Clin Genet"},{"key":"R29-4-20101208","doi-asserted-by":"crossref","first-page":"28755","DOI":"10.1074\/jbc.M603773200","volume":"281","author":"Pacheco-Alvarez","year":"2006","journal-title":"J Biol Chem"},{"key":"R30-4-20101208","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1210\/jc.2004-1905","volume":"90","author":"Lin","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"R31-4-20101208","doi-asserted-by":"crossref","first-page":"C134","DOI":"10.1152\/ajpcell.00037.2005","volume":"290","author":"Gagnon","year":"2006","journal-title":"Am J Physiol Cell Physiol"},{"key":"R32-4-20101208","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1161\/01.HYP.0000174326.96918.d6","volume":"46","author":"Golbang","year":"2005","journal-title":"Hypertension"},{"key":"R33-4-20101208","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1128\/MCB.26.2.689-698.2006","volume":"26","author":"Gagnon","year":"2006","journal-title":"Mol Cell Biol"},{"key":"R34-4-20101208","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.1242\/jcs.029223","volume":"121","author":"Richardson","year":"2008","journal-title":"J Cell Sci"},{"key":"R35-4-20101208","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1042\/BJ20071324","volume":"409","author":"Delpire","year":"2008","journal-title":"Biochem J"},{"key":"R36-4-20101208","doi-asserted-by":"crossref","first-page":"4290","DOI":"10.1038\/sj.onc.1203784","volume":"19","author":"Johnston","year":"2000","journal-title":"Oncogene"},{"key":"R37-4-20101208","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1242\/jcs.025312","volume":"121","author":"Richardson","year":"2008","journal-title":"J Cell Sci"},{"key":"R38-4-20101208","doi-asserted-by":"crossref","first-page":"27347","DOI":"10.1074\/jbc.M301899200","volume":"278","author":"Dowd","year":"2003","journal-title":"J Biol Chem"},{"key":"R39-4-20101208","doi-asserted-by":"crossref","first-page":"52848","DOI":"10.1074\/jbc.M309436200","volume":"278","author":"Piechotta","year":"2003","journal-title":"J Biol Chem"},{"key":"R40-4-20101208","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1126\/science.1075762","volume":"298","author":"Manning","year":"2002","journal-title":"Science"},{"key":"R41-4-20101208","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1042\/BJ20060220","volume":"397","author":"Vitari","year":"2006","journal-title":"Biochem J"},{"key":"R42-4-20101208","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1042\/BJ20051180","volume":"391","author":"Vitari","year":"2005","journal-title":"Biochem J"},{"key":"R43-4-20101208","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1152\/physiolgenomics.00173.2006","volume":"28","author":"Delpire","year":"2007","journal-title":"Physiol Genomics"},{"key":"R44-4-20101208","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/sj.embor.7401048","volume":"8","author":"Villa","year":"2007","journal-title":"EMBO Rep"},{"key":"R45-4-20101208","doi-asserted-by":"crossref","first-page":"42685","DOI":"10.1074\/jbc.M510042200","volume":"280","author":"Moriguchi","year":"2005","journal-title":"J Biol Chem"},{"key":"R46-4-20101208","doi-asserted-by":"crossref","first-page":"C1809","DOI":"10.1152\/ajpcell.00580.2006","volume":"292","author":"Gagnon","year":"2007","journal-title":"Am J Physiol Cell Physiol"},{"key":"R47-4-20101208","doi-asserted-by":"crossref","first-page":"8458","DOI":"10.1073\/pnas.0802966105","volume":"105","author":"Ponce-Coria","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R48-4-20101208","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1073\/pnas.0808358106","volume":"106","author":"Wang","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R49-4-20101208","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1001\/jama.288.23.2981","volume":"288","author":"","year":"2002","journal-title":"JAMA"},{"key":"R50-4-20101208","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1038\/bjp.2008.343","volume":"155","author":"El-Sheikh","year":"2008","journal-title":"Br J Pharmacol"},{"key":"R51-4-20101208","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/emmm.200900058","volume":"2","author":"Rafiqi","year":"2010","journal-title":"EMBO Mol Med"},{"key":"R52-4-20101208","doi-asserted-by":"crossref","first-page":"14109","DOI":"10.1073\/pnas.2336103100","volume":"100","author":"Zabrowicz","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R53-4-20101208","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1038\/ki.2008.451","volume":"74","author":"Chiga","year":"2008","journal-title":"Kidney Int"},{"key":"R54-4-20101208","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1073\/pnas.0808358106","volume":"106","author":"Wang","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R55-4-20101208","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/ng.118","volume":"40","author":"Ji","year":"2008","journal-title":"Nat Genet"}],"container-title":["Current Opinion in Nephrology and Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/MNH.0b013e32834132bc","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:49:56Z","timestamp":1786042196000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00041552-201101000-00004"}},"subtitle":[""],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":54,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1097\/mnh.0b013e32834132bc","relation":{},"ISSN":["1062-4821"],"issn-type":[{"value":"1062-4821","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1]]}}}