{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T03:07:14Z","timestamp":1791083234865,"version":"4.1.0"},"reference-count":52,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1097\/mnh.0b013e328362485e","type":"journal-article","created":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T16:59:29Z","timestamp":1369846769000},"page":"471-480","source":"Crossref","is-referenced-by-count":38,"title":["Pericytes in kidney fibrosis"],"prefix":"10.1097","volume":"22","author":[{"given":"Shuyu","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy S.","family":"Duffield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-17-20210205","doi-asserted-by":"crossref","first-page":"F1078","DOI":"10.1152\/ajprenal.00017.2010","article-title":"Acute kidney injury: a springboard for progression in chronic kidney disease.","volume":"298","author":"Venkatachalam","year":"2010","journal-title":"Am J Physiol Renal Physiol"},{"key":"R2-17-20210205","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2353\/ajpath.2010.090517","article-title":"Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis.","volume":"176","author":"Humphreys","year":"2010","journal-title":"Am J Pathol"},{"key":"R3-17-20210205","doi-asserted-by":"crossref","first-page":"4040","DOI":"10.1172\/JCI43025","article-title":"Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans.","volume":"120","author":"Bielesz","year":"2010","journal-title":"J Clin Invest"},{"key":"R4-17-20210205","doi-asserted-by":"crossref","first-page":"632","DOI":"10.2353\/ajpath.2010.091012","article-title":"Tubular overexpression of transforming growth factor-beta1 induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cells.","volume":"177","author":"Koesters","year":"2010","journal-title":"Am J Pathol"},{"key":"R5-17-20210205","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1159\/000084406","article-title":"Peripheral blood mononuclear cells acquire myofibroblast characteristics in granulation tissue.","volume":"42","author":"Jabs","year":"2005","journal-title":"J Vasc Res"},{"key":"R6-17-20210205","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/nm1613","article-title":"Endothelial-to-mesenchymal transition contributes to cardiac fibrosis.","volume":"13","author":"Zeisberg","year":"2007","journal-title":"Nat Med"},{"key":"R7-17-20210205","doi-asserted-by":"crossref","first-page":"C591","DOI":"10.1152\/ajpcell.00414.2012","article-title":"Cellular mechanisms of tissue fibrosis. 3. Novel mechanisms of kidney fibrosis.","volume":"304","author":"Campanholle","year":"2013","journal-title":"Am J Physiol Cell Physiol"},{"key":"R8-17-20210205","doi-asserted-by":"crossref","first-page":"167sr1","DOI":"10.1126\/scitranslmed.3004700","article-title":"Therapy for fibrotic diseases: nearing the starting line.","volume":"5","author":"Friedman","year":"2013","journal-title":"Sci Transl Med"},{"key":"R9-17-20210205","first-page":"1178","article-title":"The elusive source of myofibroblasts: problem solved Nat M","volume":"18","author":"Duffield","year":"2012","journal-title":"ed"},{"key":"R10-17-20210205","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1146\/annurev-pathol-020712-163930","article-title":"Host responses in tissue repair and fibrosis.","volume":"8","author":"Duffield","year":"2013","journal-title":"Annu Rev Pathol"},{"key":"R11-17-20210205","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1053\/j.gastro.2010.05.005","article-title":"Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice.","volume":"139","author":"Scholten","year":"2010","journal-title":"Gastroenterology"},{"key":"R12-17-20210205","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1002\/hep.23368","article-title":"Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice.","volume":"51","author":"Taura","year":"2010","journal-title":"Hepatology"},{"key":"R13-17-20210205","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.2353\/ajpath.2008.080433","article-title":"Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney.","volume":"173","author":"Lin","year":"2008","journal-title":"Am J Pathol"},{"key":"R14-17-20210205","doi-asserted-by":"crossref","first-page":"E1475","DOI":"10.1073\/pnas.1117988108","article-title":"Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition.","volume":"108","author":"Rock","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R15-17-20210205","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1126\/science.1203165","article-title":"A pericyte origin of spinal cord scar tissue.","volume":"333","author":"Goritz","year":"2011","journal-title":"Science"},{"key":"R16-17-20210205","doi-asserted-by":"crossref","first-page":"5462","DOI":"10.1038\/sj.onc.1209536","article-title":"ADAM12 is highly expressed in carcinoma-associated stroma and is required for mouse prostate tumor progression.","volume":"25","author":"Peduto","year":"2006","journal-title":"Oncogene"},{"key":"R18-17-20210205","doi-asserted-by":"crossref","first-page":"400","DOI":"10.5414\/CN107371","article-title":"The role played by perivascular cells in kidney interstitial injury.","volume":"77","author":"Rojas","year":"2012","journal-title":"Clin Nephrol"},{"key":"R19-17-20210205","doi-asserted-by":"crossref","first-page":"3981","DOI":"10.1172\/JCI57301","article-title":"Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice.","volume":"121","author":"Asada","year":"2011","journal-title":"J Clin Invest"},{"key":"R21-17-20210205","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1002\/hep.23405","article-title":"Portal fibroblasts: underappreciated mediators of biliary fibrosis.","volume":"51","author":"Dranoff","year":"2010","journal-title":"Hepatology"},{"key":"R22-17-20210205","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1016\/j.ajpath.2011.01.058","article-title":"Resident tissue-specific mesenchymal progenitor cells contribute to fibrogenesis in human lung allografts.","volume":"178","author":"Walker","year":"2011","journal-title":"Am J Pathol"},{"key":"R23-17-20210205","doi-asserted-by":"crossref","first-page":"561","DOI":"10.4161\/cam.4.4.12829","article-title":"PDGF function in diverse neural crest cell populations.","volume":"4","author":"Smith","year":"2010","journal-title":"Cell Adh Migr"},{"key":"R24-17-20210205","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.ajpath.2012.09.009","article-title":"Transforming growth factor beta-1 stimulates profibrotic epithelial signaling to activate pericyte-myofibroblast transition in obstructive kidney fibrosis.","volume":"182","author":"Wu","year":"2013","journal-title":"Am J Pathol"},{"key":"R25-17-20210205","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1681\/ASN.2011080851","article-title":"Pericyte TIMP3 and ADAMTS1 modulate vascular stability after kidney injury.","volume":"23","author":"Schrimpf","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"R26-17-20210205","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1038\/ki.2011.208","article-title":"Platelet-derived growth factor receptor signaling activates pericyte-myofibroblast transition in obstructive and postischemic kidney fibrosis.","volume":"80","author":"Chen","year":"2011","journal-title":"Kidney Int"},{"key":"R27-17-20210205","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1073\/pnas.1211179110","article-title":"LRP-6 is a coreceptor for multiple fibrogenic signaling pathways in pericytes and myofibroblasts that are inhibited by DKK-1.","volume":"110","author":"Ren","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R28-17-20210205","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/ncb2015","article-title":"Muscle injury activates resident fibroadipogenic progenitors that facilitate myogenesis.","volume":"12","author":"Joe","year":"2010","journal-title":"Nat Cell Biol"},{"key":"R29-17-20210205","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/ncb2014","article-title":"Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle.","volume":"12","author":"Uezumi","year":"2010","journal-title":"Nat Cell Biol"},{"key":"R30-17-20210205","doi-asserted-by":"crossref","first-page":"3654","DOI":"10.1242\/jcs.086629","article-title":"Fibrosis and adipogenesis originate from a common mesenchymal progenitor in skeletal muscle.","volume":"124","author":"Uezumi","year":"2011","journal-title":"J Cell Sci"},{"key":"R31-17-20210205","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.2337\/db10-1181","article-title":"Transcriptome analysis of human diabetic kidney disease.","volume":"60","author":"Woroniecka","year":"2011","journal-title":"Diabetes"},{"key":"R32-17-20210205","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/ki.2011.314","article-title":"Systems biology of kidney diseases.","volume":"81","author":"He","year":"2012","journal-title":"Kidney Int"},{"key":"R33-17-20210205","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nm.2550","article-title":"Reversible cell-cycle entry in adult kidney podocytes through regulated control of telomerase and Wnt signaling.","volume":"18","author":"Shkreli","year":"2012","journal-title":"Nat Med"},{"key":"R34-17-20210205","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1038\/ki.2011.255","article-title":"Canonical Wntbeta-catenin signaling mediates transforming growth factor-beta1-driven podocyte injury and proteinuria.","volume":"80","author":"Wang","year":"2011","journal-title":"Kidney Int"},{"key":"R35-17-20210205","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/ki.1993.45","article-title":"PDGF-receptor localizes to mesangial, parietal epithelial, and interstitial cells in human and primate kidneys.","volume":"43","author":"Alpers","year":"1993","journal-title":"Kidney Int"},{"key":"R36-17-20210205","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/ki.2011.103","article-title":"CD248 stromal cells are associated with progressive chronic kidney disease.","volume":"80","author":"Smith","year":"2011","journal-title":"Kidney Int"},{"key":"R37-17-20210205","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1182\/blood-2011-01-332338","article-title":"Pericytes promote selective vessel regression to regulate vascular patterning.","volume":"120","author":"Simonavicius","year":"2012","journal-title":"Blood"},{"key":"R38-17-20210205","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1096\/fj.07-101386","article-title":"Tumor stroma marker endosialin (Tem1) is a binding partner of metastasis-related protein Mac-2BP90K.","volume":"22","author":"Becker","year":"2008","journal-title":"FASEB J"},{"key":"R39-17-20210205","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1083\/jcb.111.2.757","article-title":"Characterization of the activation of latent TGF-beta by co-cultures of endothelial cells and pericytes or smooth muscle cells: a self-regulating system.","volume":"111","author":"Sato","year":"1990","journal-title":"J Cell Biol"},{"key":"R40-17-20210205","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/j.ajpath.2011.12.039","article-title":"Hedgehog-Gli pathway activation during kidney fibrosis.","volume":"180","author":"Fabian","year":"2012","journal-title":"Am J Pathol"},{"key":"R41-17-20210205","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1681\/ASN.2011060614","article-title":"Sonic hedgehog signaling mediates epithelial-mesenchymal communication and promotes renal fibrosis.","volume":"23","author":"Ding","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"R42-17-20210205","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.cell.2005.10.034","article-title":"Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assembly.","volume":"124","author":"Foo","year":"2006","journal-title":"Cell"},{"key":"R43-17-20210205","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1182\/blood-2008-12-192294","article-title":"EphrinB reverse signaling contributes to endothelial and mural cell assembly into vascular structures.","volume":"114","author":"Salvucci","year":"2009","journal-title":"Blood"},{"key":"R44-17-20210205","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1681\/ASN.2012080871","article-title":"Defective ephrinB2 reverse signaling promotes capillary rarefaction and fibrosis after kidney injury.","volume":"24","author":"Kida","year":"2013","journal-title":"J Am Soc Nephrol"},{"key":"R45-17-20210205","doi-asserted-by":"crossref","first-page":"F928","DOI":"10.1152\/ajprenal.00596.2007","article-title":"Renal ischemia reperfusion inhibits VEGF expression and induces ADAMTS-1, a novel VEGF inhibitor.","volume":"294","author":"Basile","year":"2008","journal-title":"Am J Physiol Renal Physiol"},{"key":"R46-17-20210205","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1161\/01.ATV.0000150045.27127.37","article-title":"Role of ADAMTS-1 in atherosclerosis: remodeling of carotid artery, immunohistochemistry, and proteolysis of versican.","volume":"25","author":"Jonsson-Rylander","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"R47-17-20210205","doi-asserted-by":"crossref","first-page":"121ra18","DOI":"10.1126\/scitranslmed.3003205","article-title":"MicroRNA-21 promotes fibrosis of the kidney by silencing metabolic pathways.","volume":"4","author":"Chau","year":"2012","journal-title":"Sci Transl Med"},{"key":"R48-17-20210205","doi-asserted-by":"crossref","first-page":"14339","DOI":"10.1073\/pnas.0912701107","article-title":"Identification of a microRNA signature of renal ischemia reperfusion injury.","volume":"107","author":"Godwin","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R49-17-20210205","doi-asserted-by":"crossref","first-page":"F793","DOI":"10.1152\/ajprenal.00273.2011","article-title":"Identification of a microRNA signature in renal fibrosis: role of miR-21.","volume":"301","author":"Zarjou","year":"2011","journal-title":"Am J Physiol Renal Physiol"},{"key":"R50-17-20210205","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s00125-012-2804-x","article-title":"Lan HY. miR-21 is a key therapeutic target for renal injury in a mouse model of type 2 diabetes.","volume":"56","author":"Zhong","year":"2013","journal-title":"Diabetologia"},{"key":"R51-17-20210205","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1038\/ki.2012.305","article-title":"Modulation of apoptosis by ischemic preconditioning: an emerging role for miR-21.","volume":"82","author":"El-Achkar","year":"2012","journal-title":"Kidney Int"},{"key":"R52-17-20210205","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.ajpath.2011.04.021","article-title":"miR-21 and miR-214 are consistently modulated during renal injury in rodent models.","volume":"179","author":"Denby","year":"2011","journal-title":"Am J Pathol"},{"key":"R53-17-20210205","doi-asserted-by":"crossref","first-page":"25586","DOI":"10.1074\/jbc.M110.208066","article-title":"MicroRNA-21 orchestrates high glucose-induced signals to TOR complex 1, resulting in renal cell pathology in diabetes.","volume":"286","author":"Dey","year":"2011","journal-title":"J Biol Chem"},{"key":"R54-17-20210205","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1358\/dnp.2010.23.5.1444206","article-title":"PRM-151 (recombinant human serum amyloid Ppentraxin 2) for the treatment of fibrosis.","volume":"23","author":"Duffield","year":"2010","journal-title":"Drug News Perspect"}],"container-title":["Current Opinion in Nephrology & Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/MNH.0b013e328362485e","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T03:29:54Z","timestamp":1620962994000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00041552-201307000-00017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1097\/mnh.0b013e328362485e","relation":{},"ISSN":["1062-4821"],"issn-type":[{"value":"1062-4821","type":"print"}],"subject":[],"published":{"date-parts":[[2013,7]]}}}