{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:23:18Z","timestamp":1790734998124,"version":"4.1.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","funder":[{"name":"Clinical Medical Science and Technology High-end Platform and Transformation Base Construction Project of Soochow University (Characteristic Discipline)\u00e2\u20ac\u201dNuclear Medicine"},{"name":"Changzhou Clinical Medical Center","award":["CZZX202204"],"award-info":[{"award-number":["CZZX202204"]}]},{"name":"Outstanding Talent of Changzhou The 14th Five-Year Plan High-Level Health Talents Training Project","award":["2022-260"],"award-info":[{"award-number":["2022-260"]}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,9]]},"abstract":"\n Objectives<\/jats:title>\n This study investigated the relationship between cardiac fibroblast activation and clinical parameters, electrophysiological findings, serum fibrosis markers, and hepatic fibroblast activation in patients with chronic liver disease.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In this prospective study conducted from December 2021 to April 2022, 46 patients with chronic liver disease underwent fluorine-18 (\n 18<\/jats:sup>\n F)\u2013labeled fibroblast activation protein inhibitor (FAPI) PET\/computed tomography (CT) imaging and 12-lead electrocardiogram (ECG). Abnormal cardiac\n 18<\/jats:sup>\n F-FAPI uptake was defined as uptake greater than that of the blood pool.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among 46 patients with chronic liver disease analyzed, 14 showed positive myocardial FAPI uptake and 32 were negative. Significant differences were observed between positive and negative myocardial\n 18<\/jats:sup>\n F-FAPI PET\/CT imaging groups in terms of age (\n P<\/jats:italic>\n \u2009=\u20090.006), epicardial fat volume (EFV) (\n P<\/jats:italic>\n \u2009=\u20090.004), Cornell voltage QRS amplitude (\n P<\/jats:italic>\n \u2009=\u20090.022), and QRS duration (\n P<\/jats:italic>\n \u2009=\u20090.032). The multivariable logistic regression analysis demonstrated a significant association between EFV [odds ratio (OR)\u2009=\u20091.019;\n P<\/jats:italic>\n \u2009=\u20090.024] and age (OR\u2009=\u20091.162;\n P<\/jats:italic>\n \u2009=\u20090.019) and positive myocardial FAPI uptake. Myocardial maximum target-to-background ratio (TBR\n max<\/jats:sub>\n ) was positively correlated with hepatic TBR\n max<\/jats:sub>\n (\n r<\/jats:italic>\n \u2009=\u20090.405;\n P<\/jats:italic>\n \u2009=\u20090.005) and hepatic TBR\n mean<\/jats:sub>\n (\n r<\/jats:italic>\n \u2009=\u20090.412,\n P<\/jats:italic>\n \u2009=\u20090.004). Moreover, myocardial maximum standardized uptake value was positively correlated with serum laminin levels (\n r<\/jats:italic>\n \u2009=\u20090.367;\n P<\/jats:italic>\n \u2009=\u20090.042).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In patients with chronic liver disease, FAPI PET\/CT imaging observed cardiac fibroblast activation, which was associated with electrophysiological parameters, hepatic FAPI uptake, and serum liver fibrosis markers. These findings suggest that\n 18<\/jats:sup>\n F-FAPI PET\/CT imaging may offer a noninvasive approach for identifying early myocardial changes in chronic liver disease.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1097\/mnm.0000000000002002","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T04:00:08Z","timestamp":1749096008000},"page":"824-834","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["18F-FAPI PET\/CT in chronic liver disease: myocardial fibroblast activation and its correlates"],"prefix":"10.1097","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1720-6657","authenticated-orcid":false,"given":"Yangyang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu Province"},{"name":"PET Center, Department of Nuclear 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