{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:16:52Z","timestamp":1786119412637,"version":"build-2736575974"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Opinion in Hematology"],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1097\/moh.0b013e3283366be1","type":"journal-article","created":{"date-parts":[[2010,2,9]],"date-time":"2010-02-09T01:55:00Z","timestamp":1265680500000},"page":"91-96","source":"Crossref","is-referenced-by-count":13,"title":["Molecular pathogenesis of tyrosine kinase resistance in chronic myeloid leukemia"],"prefix":"10.1097","volume":"17","author":[{"given":"Paul","family":"La Ros\u00e9e","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Hochhaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-5-20100209","doi-asserted-by":"crossref","first-page":"4808","DOI":"10.1182\/blood-2008-07-077958","volume":"112","author":"Druker","year":"2008","journal-title":"Blood"},{"key":"R2-5-20100209","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1056\/NEJMoa062867","volume":"355","author":"Druker","year":"2006","journal-title":"N Engl J Med"},{"key":"R3-5-20100209","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1038\/leu.2009.38","volume":"23","author":"Hochhaus","year":"2009","journal-title":"Leukemia"},{"key":"R4-5-20100209","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1182\/blood-2007-07-103523","volume":"111","author":"Hochhaus","year":"2008","journal-title":"Blood"},{"key":"R5-5-20100209","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1182\/blood-2004-04-1335","volume":"104","author":"Cortes","year":"2004","journal-title":"Blood"},{"key":"R7-5-20100209","doi-asserted-by":"crossref","first-page":"6041","DOI":"10.1200\/JCO.2009.25.0779","volume":"27","author":"Baccarani","year":"2009","journal-title":"J Clin Oncol"},{"key":"R8-5-20100209","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/S1470-2045(07)70342-X","volume":"8","author":"Apperley","year":"2007","journal-title":"Lancet Oncol"},{"key":"R9-5-20100209","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1182\/blood-2007-03-066936","volume":"110","author":"O\u02bcHare","year":"2007","journal-title":"Blood"},{"key":"R10-5-20100209","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1182\/blood-2009-01-197186","volume":"114","author":"Soverini","year":"2009","journal-title":"Blood"},{"key":"R11-5-20100209","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1126\/science.289.5486.1938","volume":"289","author":"Schindler","year":"2000","journal-title":"Science"},{"key":"R12-5-20100209","first-page":"4236","volume":"62","author":"Nagar","year":"2002","journal-title":"Cancer Res"},{"key":"R13-5-20100209","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1038\/nsmb.1486","volume":"15","author":"Azam","year":"2008","journal-title":"Nat Struct Mol Biol"},{"key":"R14-5-20100209","doi-asserted-by":"crossref","first-page":"5271","DOI":"10.1182\/blood-2009-04-219410","volume":"114","author":"Nicolini","year":"2009","journal-title":"Blood"},{"key":"R15-5-20100209","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/leu.2008.3","volume":"22","author":"Liu","year":"2008","journal-title":"Leukemia"},{"key":"R17-5-20100209","doi-asserted-by":"crossref","first-page":"e6124","DOI":"10.1371\/journal.pone.0006124","volume":"4","author":"Aceves-Luquero","year":"2009","journal-title":"PLoS One"},{"key":"R18-5-20100209","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1158\/0008-5472.CAN-07-6858","volume":"68","author":"Stoklosa","year":"2008","journal-title":"Cancer Res"},{"key":"R19-5-20100209","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1038\/leu.2008.78","volume":"22","author":"Koptyra","year":"2008","journal-title":"Leukemia"},{"key":"R20-5-20100209","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1182\/blood-2008-07-172148","volume":"114","author":"Fernandes","year":"2009","journal-title":"Blood"},{"key":"R21-5-20100209","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1182\/blood-2003-04-1271","volume":"103","author":"Chu","year":"2004","journal-title":"Blood"},{"key":"R22-5-20100209","doi-asserted-by":"crossref","first-page":"4532","DOI":"10.1182\/blood-2005-07-2947","volume":"107","author":"Copland","year":"2006","journal-title":"Blood"},{"key":"R23-5-20100209","doi-asserted-by":"crossref","first-page":"9624","DOI":"10.1158\/0008-5472.CAN-08-1131","volume":"68","author":"Konig","year":"2008","journal-title":"Cancer Res"},{"key":"R24-5-20100209","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1182\/blood-2007-05-092056","volume":"111","author":"Konig","year":"2008","journal-title":"Blood"},{"key":"R25-5-20100209","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/sj.leu.2405086","volume":"22","author":"Konig","year":"2008","journal-title":"Leukemia"},{"key":"R26-5-20100209","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1182\/blood-2004-03-1114","volume":"105","author":"Chu","year":"2005","journal-title":"Blood"},{"key":"R27-5-20100209","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1038\/sj.leu.2404609","volume":"21","author":"Jiang","year":"2007","journal-title":"Leukemia"},{"key":"R28-5-20100209","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.ccr.2009.07.030","volume":"16","author":"Klemm","year":"2009","journal-title":"Cancer Cell"},{"key":"R29-5-20100209","doi-asserted-by":"crossref","first-page":"4204","DOI":"10.1200\/JCO.2009.21.8230","volume":"27","author":"Hughes","year":"2009","journal-title":"J Clin Oncol"},{"key":"R30-5-20100209","doi-asserted-by":"crossref","first-page":"4944","DOI":"10.1182\/blood-2009-04-214221","volume":"114","author":"Muller","year":"2009","journal-title":"Blood"},{"key":"R32-5-20100209","doi-asserted-by":"crossref","first-page":"3428","DOI":"10.1182\/blood-2007-08-103499","volume":"113","author":"Castagnetti","year":"2009","journal-title":"Blood"},{"key":"R33-5-20100209","doi-asserted-by":"crossref","first-page":"4933","DOI":"10.1182\/blood-2009-07-232595","volume":"114","author":"Rosti","year":"2009","journal-title":"Blood"},{"key":"R34-5-20100209","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1038\/sj.leu.2402555","volume":"16","author":"La Ros\u00e9e","year":"2002","journal-title":"Leukemia"},{"key":"R35-5-20100209","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.ccr.2009.09.028","volume":"16","author":"O\u02bcHare","year":"2009","journal-title":"Cancer Cell"},{"key":"R36-5-20100209","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1182\/blood-2006-05-025049","volume":"109","author":"Giles","year":"2007","journal-title":"Blood"},{"key":"R37-5-20100209","first-page":"459","volume":"90","author":"Crossman","year":"2005","journal-title":"Haematologica"},{"key":"R38-5-20100209","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1073\/pnas.0510423103","volume":"103","author":"Radich","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R40-5-20100209","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1056\/NEJMoa040258","volume":"351","author":"Jamieson","year":"2004","journal-title":"N Engl J Med"},{"key":"R41-5-20100209","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1158\/1535-7163.MCT-07-2331","volume":"7","author":"Weisberg","year":"2008","journal-title":"Mol Cancer Ther"},{"key":"R42-5-20100209","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1182\/blood.V99.1.319","volume":"99","author":"Graham","year":"2002","journal-title":"Blood"},{"key":"R43-5-20100209","doi-asserted-by":"crossref","first-page":"5191","DOI":"10.1182\/blood-2008-08-176016","volume":"114","author":"Lemoli","year":"2009","journal-title":"Blood"},{"key":"R44-5-20100209","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/nature07815","volume":"458","author":"Essers","year":"2009","journal-title":"Nature"},{"key":"R45-5-20100209","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1182\/blood-2003-12-4369","volume":"105","author":"Koschmieder","year":"2005","journal-title":"Blood"},{"key":"R46-5-20100209","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1182\/blood-2008-03-147744","volume":"112","author":"Dulucq","year":"2008","journal-title":"Blood"},{"key":"R47-5-20100209","doi-asserted-by":"crossref","first-page":"5401","DOI":"10.1182\/blood-2008-12-196543","volume":"113","author":"Noens","year":"2009","journal-title":"Blood"},{"key":"R48-5-20100209","doi-asserted-by":"crossref","first-page":"4022","DOI":"10.1182\/blood-2007-10-116475","volume":"111","author":"Larson","year":"2008","journal-title":"Blood"},{"key":"R49-5-20100209","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1056\/NEJMoa055229","volume":"354","author":"Talpaz","year":"2006","journal-title":"N Engl J Med"},{"key":"R50-5-20100209","doi-asserted-by":"crossref","first-page":"3204","DOI":"10.1200\/JCO.2007.14.9260","volume":"26","author":"Shah","year":"2008","journal-title":"J Clin Oncol"},{"key":"R51-5-20100209","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.ccr.2008.11.001","volume":"14","author":"Shah","year":"2008","journal-title":"Cancer Cell"},{"key":"R52-5-20100209","doi-asserted-by":"crossref","first-page":"3459","DOI":"10.1182\/blood-2007-10-113969","volume":"114","author":"Snead","year":"2009","journal-title":"Blood"},{"key":"R53-5-20100209","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/leu.2009.45","volume":"23","author":"Hiwase","year":"2009","journal-title":"Leukemia"}],"container-title":["Current Opinion in Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/MOH.0b013e3283366be1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:10:51Z","timestamp":1786039851000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00062752-201003000-00005"}},"subtitle":[""],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":49,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1097\/moh.0b013e3283366be1","relation":{},"ISSN":["1065-6251"],"issn-type":[{"value":"1065-6251","type":"print"}],"subject":[],"published":{"date-parts":[[2010,3]]}}}