{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:28:39Z","timestamp":1790141319956,"version":"4.0.1"},"reference-count":60,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1097\/mol.0b013e3283462273","type":"journal-article","created":{"date-parts":[[2011,4,14]],"date-time":"2011-04-14T07:59:14Z","timestamp":1302767954000},"page":"186-191","source":"Crossref","is-referenced-by-count":60,"title":["Role of peripheral serotonin in glucose and lipid metabolism"],"prefix":"10.1097","volume":"22","author":[{"given":"Hitoshi","family":"Watanabe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T","family":"Rose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Aso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-7-20211004","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1073\/pnas.90.6.2542","article-title":"Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization","volume":"90","author":"Ramamoorthy","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R2-7-20211004","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1126\/science.7792602","article-title":"Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA","volume":"268","author":"Cases","year":"1995","journal-title":"Science"},{"key":"R3-7-20211004","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/374542a0","article-title":"Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors","volume":"374","author":"Tecott","year":"1995","journal-title":"Nature"},{"key":"R4-7-20211004","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/30259","article-title":"Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor","volume":"393","author":"Rocha","year":"1998","journal-title":"Nature"},{"key":"R5-7-20211004","doi-asserted-by":"crossref","first-page":"10734","DOI":"10.1073\/pnas.95.18.10734","article-title":"Increased anxiety of mice lacking the serotonin1A receptor","volume":"95","author":"Parks","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R6-7-20211004","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1126\/science.283.5400.397","article-title":"Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity","volume":"283","author":"Gainetdinov","year":"1999","journal-title":"Science"},{"key":"R7-7-20211004","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1126\/science.108.2804.329","article-title":"Crystalline serotonin","volume":"108","author":"Rapport","year":"1948","journal-title":"Science"},{"key":"R8-7-20211004","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1093\/cvr\/24.11.932","article-title":"5-Hydroxytryptamine receptor profile in healthy and diseased human epicardial coronary arteries","volume":"24","author":"Chester","year":"1990","journal-title":"Cardiovasc Res"},{"key":"R9-7-20211004","first-page":"4","article-title":"Contractile responses to tryptamine analogues in isolated smooth muscle","volume":"229","author":"Hixson","year":"1977","journal-title":"Arch Int Phamacodyn Ther"},{"key":"R10-7-20211004","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3181\/00379727-151-39137","article-title":"Serotonin deficiency and prolonged bleeding in beige mice","volume":"151","author":"Holland","year":"1976","journal-title":"Proc Soc Exp Biol Med"},{"key":"R11-7-20211004","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1126\/science.1123842","article-title":"Platelet-derived serotonin mediates liver regeneration","volume":"312","author":"Lesurtel","year":"2006","journal-title":"Science"},{"key":"R12-7-20211004","doi-asserted-by":"crossref","first-page":"557","DOI":"10.4049\/jimmunol.157.2.557","article-title":"Delayed-type hypersensitivity in mast cell-deficient mice: dependence on platelets for expression of contact sensitivity","volume":"157","author":"Geba","year":"1996","journal-title":"J Immunol"},{"key":"R13-7-20211004","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1126\/science.1078197","article-title":"Synthesis of serotonin by a second tryptophan hydroxylase isoform","volume":"299","author":"Walther","year":"2003","journal-title":"Science"},{"key":"R14-7-20211004","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1016\/S0006-2952(03)00556-2","article-title":"A unique central tryptophan hydroxylase isoform","volume":"66","author":"Walther","year":"2003","journal-title":"Biochem Pharmacol"},{"key":"R15-7-20211004","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1073\/pnas.40.4.228","article-title":"A biological and pharmacological suggestion about certain mental disorders","volume":"40","author":"Woolley","year":"1954","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R16-7-20211004","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF01323461","article-title":"Studies on blood\u2013brain barrier permeability after microwave-radiation","volume":"15","author":"Merritt","year":"1978","journal-title":"Radiat Environ Biophys"},{"key":"R17-7-20211004","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0091-3057(01)00746-8","article-title":"Molecular, pharmacological and functional diversity of 5-HT receptors","volume":"71","author":"Hoyer","year":"2002","journal-title":"Pharmacol Biochem Behav"},{"key":"R18-7-20211004","doi-asserted-by":"crossref","first-page":"4776","DOI":"10.1210\/en.2009-1349","article-title":"Peripheral serotonin enhances lipid metabolism by accelerating bile acid turnover","volume":"151","author":"Watanabe","year":"2010","journal-title":"Endocrinology"},{"key":"R19-7-20211004","doi-asserted-by":"crossref","first-page":"14","DOI":"10.2337\/diabetes.53.1.14","article-title":"Portal infusion and glucose disposal in conscious dogs","volume":"53","author":"Moore","year":"2004","journal-title":"Diabetes"},{"key":"R20-7-20211004","doi-asserted-by":"crossref","first-page":"13563","DOI":"10.1074\/jbc.274.19.13563","article-title":"Serotonin (5-hydroxytryptamine), a novel regulator of glucose transport in rat skeletal muscle","volume":"274","author":"Hajduch","year":"1999","journal-title":"J Biol Chem"},{"key":"R21-7-20211004","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1210\/me.2010-0054","article-title":"Regulation of adipocyte differentiation by activation of serotonin (5-HT) receptors 5-HT2AR and 5-HT2CR and involvement of microRNA-448-mediated repression of KLF5","volume":"24","author":"Kinoshita","year":"2010","journal-title":"Mol Endocrinol"},{"key":"R22-7-20211004","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.cmet.2008.04.012","article-title":"Serotonin regulates C. elegans fat and feeding through independent molecular mechanisms","volume":"7","author":"Srinivasan","year":"2008","journal-title":"Cell Metab"},{"key":"R23-7-20211004","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1016\/0024-3205(89)90547-X","article-title":"Serotonin-induced hypoglycemia and increased serum insulin levels in mice","volume":"45","author":"Yamada","year":"1989","journal-title":"Life Sci"},{"key":"R24-7-20211004","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1254\/jjp.54.93","article-title":"Effects of serotonin on blood glucose and insulin levels of glucose- and streptozotocin-treated mice","volume":"54","author":"Sugimoto","year":"1990","journal-title":"Jpn J Pharmacol"},{"key":"R25-7-20211004","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1385\/ENDO:23:1:11","article-title":"Effects of prior 5-hydroxytryptamine exposure on rat islet insulin secretory and phospholipase C responses","volume":"23","author":"Zawalich","year":"2004","journal-title":"Endocrine"},{"key":"R26-7-20211004","doi-asserted-by":"crossref","first-page":"e1000229","DOI":"10.1371\/journal.pbio.1000229","article-title":"Intracellular serotonin modulates insulin secretion from pancreatic beta-cells by protein serotonylation","volume":"7","author":"Paulmann","year":"2009","journal-title":"PLoS Biol"},{"key":"R27-7-20211004","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S1534-5807(04)00022-X","article-title":"Serotonin regulates mammary gland development via an autocrine\u2013paracrine loop","volume":"6","author":"Matsuda","year":"2004","journal-title":"Dev Cell"},{"key":"R28-7-20211004","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/nm.2173","article-title":"Serotonin regulates pancreatic beta cell mass during pregnancy","volume":"16","author":"Kim","year":"2010","journal-title":"Nat Med"},{"key":"R29-7-20211004","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0014-2999(90)90205-K","article-title":"Ganglionic transmission is a prerequisite for the adrenaline-releasing and hyperglycemic effects of 8-OH-DPAT","volume":"185","author":"Chaouloff","year":"1990","journal-title":"Eur J Pharmacol"},{"key":"R30-7-20211004","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0021-5198(19)32437-0","article-title":"The effects of the serotonin1A receptor agonist buspirone on the blood glucose and pancreatic hormones in rats","volume":"60","author":"Sugimoto","year":"1992","journal-title":"Jpn J Pharmacol"},{"key":"R31-7-20211004","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/0024-3205(95)02010-G","article-title":"The involvement of the peripheral 5-HT2A receptor in peripherally administered serotonin-induced hyperglycemia in rats","volume":"57","author":"Yamada","year":"1995","journal-title":"Life Sci"},{"key":"R32-7-20211004","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1007\/s00125-007-0696-y","article-title":"Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs","volume":"50","author":"Hampson","year":"2007","journal-title":"Diabetologia"},{"key":"R33-7-20211004","doi-asserted-by":"crossref","first-page":"E225","DOI":"10.1152\/ajpendo.00614.2004","article-title":"Portal 5-hydroxytryptophan infusion enhances glucose disposal in conscious dogs","volume":"289","author":"Moore","year":"2005","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"R34-7-20211004","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0195-6663(86)80051-4","article-title":"Serotonin manipulations and the structure of feeding behavior","volume":"7","author":"Blundell","year":"1986","journal-title":"Appetite"},{"key":"R35-7-20211004","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.1749-6632.1990.tb16907.x","article-title":"Serotonin and appetite.","volume":"600","author":"Curzon","year":"1990","journal-title":"Ann N Y Acad Sci"},{"issue":"Suppl. 1","key":"R36-7-20211004","first-page":"S51","article-title":"Hypothalamic serotonin: pharmacological, biochemical, and behavioral analyses of its feeding-suppressive action","volume":"11","author":"Leibowitz","year":"1988","journal-title":"Clin Neuropharmacol"},{"key":"R37-7-20211004","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0166-4328(96)00066-6","article-title":"Serotonergic control of the organization of feeding and satiety","volume":"73","author":"Simansky","year":"1996","journal-title":"Behav Brain Res"},{"key":"R38-7-20211004","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S0006-3223(98)00186-3","article-title":"Hypothalamic serotonin in control of eating behavior, meal size, and body weight","volume":"44","author":"Leibowitz","year":"1998","journal-title":"Biol Psychiatry"},{"key":"R39-7-20211004","doi-asserted-by":"crossref","first-page":"3395","DOI":"10.1038\/emboj.2010.197","article-title":"The nuclear receptor PPAR\u03b3 individually responds to serotonin- and fatty acid-metabolites","volume":"29","author":"Waku","year":"2010","journal-title":"EMBO J"},{"key":"R40-7-20211004","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1021\/pr100892r","article-title":"Metabolomic analysis of livers and serum from high-fat diet induced obese mice","volume":"10","author":"Kim","year":"2011","journal-title":"J Proteome Res"},{"key":"R41-7-20211004","doi-asserted-by":"crossref","first-page":"G260","DOI":"10.1152\/ajpgi.00056.2008","article-title":"Luminal regulation of normal and neoplastic human EC cell serotonin release is mediated by bile salts, amines tastants, and olfactants","volume":"295","author":"Kidd","year":"2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"Suppl 2","key":"R42-7-20211004","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1046\/j.1365-2036.1999.00002.x-i2","article-title":"Review article: serotonin roles played by 5-hydroxytryptamine in the physiology of the bowel","volume":"13","author":"Gershon","year":"1999","journal-title":"Aliment Pharmacol Ther"},{"key":"R43-7-20211004","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/sj.bjp.0702615","article-title":"Involvement of serotonin and calcium channels in the intestinal fluid secretion evoked by bile salt and cholera toxin","volume":"127","author":"Peregrin","year":"1999","journal-title":"Br J Pharmacol"},{"key":"R44-7-20211004","first-page":"83","article-title":"Regulation of 5-HT release from enterochromaffin cells Behav","volume":"73","author":"Racke","year":"1996","journal-title":"Brain Res"},{"key":"R45-7-20211004","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1469-7793.2001.0431k.x","article-title":"Intestinal serotonin acts as a paracrine substance to mediate vagal signal transmission evoked by luminal factors in the rat","volume":"530","author":"Zhu","year":"2001","journal-title":"J Physiol"},{"key":"R46-7-20211004","doi-asserted-by":"crossref","first-page":"29971","DOI":"10.1074\/jbc.M501931200","article-title":"The farnesoid X receptor modulates hepatic carbohydrate metabolism during the fasting-refeeding transition","volume":"280","author":"Duran-Sandoval","year":"2005","journal-title":"J Biol Chem"},{"key":"R47-7-20211004","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1073\/pnas.0506982103","article-title":"Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice","volume":"103","author":"Zhang","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R48-7-20211004","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1172\/JCI21025","article-title":"Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c","volume":"113","author":"Watanabe","year":"2004","journal-title":"J Clin Invest"},{"key":"R49-7-20211004","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nature04330","article-title":"Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation","volume":"439","author":"Watanabe","year":"2006","journal-title":"Nature"},{"key":"R50-7-20211004","first-page":"283","article-title":"The effect of serotonin on bile secretion in dugs","volume":"62","author":"Bogach","year":"1976","journal-title":"Fiziol Zh SSSR Im I M Sechenova"},{"key":"R51-7-20211004","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1152\/ajplegacy.1928.86.3.599","article-title":"A hormone mechanism of gallbladder contraction and evacuation","volume":"86","author":"Ivy","year":"1928","journal-title":"Am J Physiol"},{"key":"R52-7-20211004","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1046\/j.1365-2982.1997.d01-62.x","article-title":"5-HT receptor types in the rat ileum longitudinal muscle: focus on 5-HT2 receptors mediating contraction","volume":"9","author":"Briejer","year":"1997","journal-title":"Neurogastroenterol Motil"},{"key":"R53-7-20211004","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1038\/nm1501","article-title":"Identification of a hormonal basis for gallbladder filling","volume":"12","author":"Choi","year":"2006","journal-title":"Nat Med"},{"key":"R54-7-20211004","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1146\/annurev.biochem.72.121801.161712","article-title":"The enzymes, regulation, and genetics of bile acid synthesis","volume":"72","author":"Russell","year":"2003","journal-title":"Annu Rev Biochem"},{"key":"R55-7-20211004","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.cmet.2005.09.001","article-title":"Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis","volume":"2","author":"Inagaki","year":"2005","journal-title":"Cell Metab"},{"key":"R56-7-20211004","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1172\/JCI119355","article-title":"Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2)","volume":"99","author":"Oelkers","year":"1997","journal-title":"J Clin Invest"},{"key":"R57-7-20211004","doi-asserted-by":"crossref","first-page":"33920","DOI":"10.1074\/jbc.M306370200","article-title":"Targeted deletion of the ileal bile acid transporter eliminates enterohepatic cycling of bile acids in mice","volume":"278","author":"Dawson","year":"2003","journal-title":"J Biol Chem"},{"key":"R58-7-20211004","doi-asserted-by":"crossref","first-page":"G996","DOI":"10.1152\/ajpgi.90343.2008","article-title":"Beta-Klotho and FGF-15\/19 inhibit the apical sodium-dependent bile acid transporter in enterocytes and cholangiocytes","volume":"295","author":"Sinha","year":"2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"R59-7-20211004","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/hep.20295","article-title":"Bile acid-induced negative feedback regulation of the human ileal bile acid transporter","volume":"40","author":"Neimark","year":"2004","journal-title":"Hepatology"},{"key":"R60-7-20211004","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1194\/jlr.M700351-JLR200","article-title":"FXR agonists and FGF15 reduce fecal bile acid excretion in a mouse model of bile acid malabsorption","volume":"48","author":"Jung","year":"2007","journal-title":"J Lipid Res"}],"container-title":["Current Opinion in Lipidology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/00041433-201106000-00007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T08:56:02Z","timestamp":1686041762000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00041433-201106000-00007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":60,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1097\/mol.0b013e3283462273","relation":{},"ISSN":["0957-9672"],"issn-type":[{"value":"0957-9672","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]}}}