{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:09:25Z","timestamp":1786118965333,"version":"build-2736575974"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,8]]},"DOI":"10.1097\/moo.0b013e328304b445","type":"journal-article","created":{"date-parts":[[2008,7,14]],"date-time":"2008-07-14T03:06:05Z","timestamp":1216004765000},"page":"325-330","source":"Crossref","is-referenced-by-count":14,"title":["Bisphosphonate-induced necrosis of the jaws: a reconstructive nightmare"],"prefix":"10.1097","volume":"16","author":[{"given":"Artur","family":"Gevorgyan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny J","family":"Enepekides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-5-20210206","first-page":"1361","article-title":"Bisphosphonates: mechanisms of action","author":"Fleisch","year":"2002"},{"key":"R2-5-20210206","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1093\/annonc\/mdg401","article-title":"The antineoplastic role of bisphosphonates: from basic research to clinical evidence","volume":"14","author":"Santini","year":"2003","journal-title":"Ann Oncol"},{"key":"R3-5-20210206","doi-asserted-by":"crossref","first-page":"753","DOI":"10.7326\/0003-4819-144-10-200605160-00009","article-title":"Narrative [corrected] review: bisphosphonates and osteonecrosis of the jaws","volume":"144","author":"Woo","year":"2006","journal-title":"Ann Intern Med"},{"key":"R4-5-20210206","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1056\/NEJMp068157","article-title":"Osteonecrosis of the jaw: do bisphosphonates pose a risk?","volume":"355","author":"Bilezikian","year":"2006","journal-title":"N Engl J Med"},{"key":"R5-5-20210206","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1056\/NEJMoa023110","article-title":"Bisphosphonate-induced osteopetrosis","volume":"349","author":"Whyte","year":"2003","journal-title":"N Engl J Med"},{"key":"R6-5-20210206","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0278-2391(03)00720-1","article-title":"Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic","volume":"61","author":"Marx","year":"2003","journal-title":"J Oral Maxillofac Surg"},{"key":"R7-5-20210206","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1359\/jbmr.0707onj","article-title":"Bisphosphonate-associated osteonecrosis of the jaw: report of a task force of the American Society for Bone and Mineral Research","volume":"22","author":"Khosla","year":"2007","journal-title":"J Bone Miner Res"},{"key":"R8-5-20210206","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.3174\/ajnr.A0518","article-title":"Imaging findings of bisphosphonate-associated osteonecrosis of the jaws","volume":"28","author":"Phal","year":"2007","journal-title":"AJNR Am J Neuroradiol"},{"key":"R9-5-20210206","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s00277-007-0263-0","article-title":"Sestamibi and FDG-PET scans to support diagnosis of jaw osteonecrosis","volume":"86","author":"Catalano","year":"2007","journal-title":"Ann Hematol"},{"key":"R10-5-20210206","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.tripleo.2007.01.040","article-title":"Computerized tomographic findings in bisphosphonate-associated osteonecrosis of the jaw in patients with cancer","volume":"104","author":"Bianchi","year":"2007","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"R11-5-20210206","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/j.joms.2005.07.010","article-title":"Bisphosphonate-induced exposed bone (osteonecrosis\/osteopetrosis) of the jaws: risk factors, recognition, prevention, and treatment","volume":"63","author":"Marx","year":"2005","journal-title":"J Oral Maxillofac Surg"},{"key":"R12-5-20210206","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0278-2391(83)90294-X","article-title":"Osteoradionecrosis: a new concept of its pathophysiology","volume":"41","author":"Marx","year":"1983","journal-title":"J Oral Maxillofac Surg"},{"key":"R13-5-20210206","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1054\/ijom.2002.0332","article-title":"Osteoradionecrosis of the jaws as a side effect of radiotherapy of head and neck tumour patients: a report of a thirty year retrospective review","volume":"32","author":"Reuther","year":"2003","journal-title":"Int J Oral Maxillofac Surg"},{"key":"R14-5-20210206","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.joms.2004.02.004","article-title":"Osteonecrosis of the jaws associated with the use of bisphosphonates: a review of 63 cases","volume":"62","author":"Ruggiero","year":"2004","journal-title":"J Oral Maxillofac Surg"},{"key":"R15-5-20210206","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/ajh.20481","article-title":"Osteonecrosis of the jaw associated with pamidronate therapy","volume":"81","author":"Zarychanski","year":"2006","journal-title":"Am J Hematol"},{"key":"R16-5-20210206","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.ijom.2006.02.022","article-title":"Bisphosphonate-induced avascular osteonecrosis of the jaws: a clinical report of 11 cases","volume":"35","author":"Dimitrakopoulos","year":"2006","journal-title":"Int J Oral Maxillofac Surg"},{"key":"R17-5-20210206","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s00508-006-0644-8","article-title":"Osteonecrosis of the jaws and bisphosphonate treatment in cancer patients","volume":"118","author":"Wutzl","year":"2006","journal-title":"Wien Klin Wochenschr"},{"key":"R18-5-20210206","first-page":"109","article-title":"Bone necrosis of the jaws associated with bisphosphonate treatment: a report of twenty-nine cases","volume":"77","author":"Merigo","year":"2006","journal-title":"Acta Biomed"},{"key":"R19-5-20210206","first-page":"504","article-title":"Clinical experiences with bisphosphonate induced osteochemonecrosis of the jaws","volume":"136","author":"Dannemann","year":"2006","journal-title":"Swiss Med Wkly"},{"key":"R20-5-20210206","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1097\/01.scs.0000249350.59096.d0","article-title":"New therapeutic protocol in the treatment of avascular necrosis of the jaws","volume":"17","author":"Agrillo","year":"2006","journal-title":"J Craniofac Surg"},{"key":"R21-5-20210206","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1532\/IJH97.06110","article-title":"Hyperbaric oxygen in addition to antibiotic therapy is effective for bisphosphonate-induced osteonecrosis of the jaw in a patient with multiple myeloma","volume":"84","author":"Shimura","year":"2006","journal-title":"Int J Hematol"},{"key":"R22-5-20210206","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1080\/10428190600977690","article-title":"Bisphosphonate-associated osteonecrosis of the jaw: a review of 35 cases and an evaluation of its frequency in multiple myeloma patients","volume":"48","author":"Pozzi","year":"2007","journal-title":"Leuk Lymphoma"},{"key":"R23-5-20210206","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.ctrv.2006.09.003","article-title":"Bisphosphonate-related jaw necrosis: severe complication in maxillofacial surgery","volume":"33","author":"Eckert","year":"2007","journal-title":"Cancer Treat Rev"},{"key":"R24-5-20210206","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.joms.2006.10.061","article-title":"Nature and frequency of bisphosphonate-associated osteonecrosis of the jaws in Australia","volume":"65","author":"Mavrokokki","year":"2007","journal-title":"J Oral Maxillofac Surg"},{"key":"R25-5-20210206","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.amjoto.2006.08.004","article-title":"Osteonecrosis of the jaws due to bisphosphonate use. A review of 60 cases and treatment proposals","volume":"28","author":"Magopoulos","year":"2007","journal-title":"Am J Otolaryngol"},{"key":"R26-5-20210206","first-page":"E267","article-title":"Osteonecrosis of the jaws and bisphosphonates. Report of fifteen cases. Therapeutic recommendations","volume":"12","author":"Heras Rincon","year":"2007","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"R27-5-20210206","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1097\/scs.0b013e3180f611ef","article-title":"Surgical therapy for osteonecrotic lesions of the jaws in patients in therapy with bisphosphonates","volume":"18","author":"Longobardi","year":"2007","journal-title":"J Craniofac Surg"},{"key":"R28-5-20210206","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1007\/s00198-007-0384-2","article-title":"Osteonecrosis of the jaw induced by orally administered bisphosphonates: incidence, clinical features, predisposing factors and treatment outcome","volume":"18","author":"Yarom","year":"2007","journal-title":"Osteoporos Int"},{"key":"R29-5-20210206","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jbspin.2007.05.003","article-title":"Thirteen cases of jaw osteonecrosis in patients on bisphosphonate therapy","volume":"75","author":"Vieillard","year":"2008","journal-title":"Joint Bone Spine"},{"key":"R30-5-20210206","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1159\/000097876","article-title":"Bisphosphonate-associated osteonecrosis of the jaw in patients with multiple myeloma and breast cancer","volume":"117","author":"Nastro","year":"2007","journal-title":"Acta Haematol"},{"key":"R31-5-20210206","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jcms.2007.06.008","article-title":"\u2018Bis-phossy jaws\u2019 \u2013 high and low risk factors for bisphosphonate-induced osteonecrosis of the jaw","volume":"36","author":"Abu-Id","year":"2008","journal-title":"J Craniomaxillofac Surg"},{"key":"R32-5-20210206","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1016\/j.joms.2007.08.003","article-title":"Oral bisphosphonate-induced osteonecrosis: risk factors, prediction of risk using serum CTX testing, prevention, and treatment","volume":"65","author":"Marx","year":"2007","journal-title":"J Oral Maxillofac Surg"},{"key":"R33-5-20210206","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/j.joms.2007.03.019","article-title":"Hyperbaric oxygen treatment and bisphosphonate-induced osteonecrosis of the jaw: a case series","volume":"65","author":"Freiberger","year":"2007","journal-title":"J Oral Maxillofac Surg"},{"key":"R34-5-20210206","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.tripleo.2007.01.008","article-title":"Bisphosphonate-associated osteonecrosis can be controlled by nonsurgical management","volume":"104","author":"Montebugnoli","year":"2007","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"R35-5-20210206","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.bjoms.2007.03.016","article-title":"Nd:YAG laser biostimulation of bisphosphonate-associated necrosis of the jawbone with and without surgical treatment","volume":"45","author":"Vescovi","year":"2007","journal-title":"Br J Oral Maxillofac Surg"},{"key":"R36-5-20210206","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1089\/pho.2007.2181","article-title":"Nd:YAG laser biostimulation in the treatment of bisphosphonate-associated osteonecrosis of the jaw: clinical experience in 28 cases","volume":"26","author":"Vescovi","year":"2008","journal-title":"Photomed Laser Surg"},{"key":"R37-5-20210206","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1097\/scs.0b013e31857261f","article-title":"Ozone therapy in the treatment of avascular bisphosphonate-related jaw osteonecrosis","volume":"18","author":"Agrillo","year":"2007","journal-title":"J Craniofac Surg"},{"key":"R38-5-20210206","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.joms.2006.11.003","article-title":"Paper on bisphosphonate-related osteonecrosis of the jaws.","volume":"65","year":"2007","journal-title":"J Oral Maxillofac Surg"},{"key":"R39-5-20210206","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.14219\/jada.archive.2006.0355","article-title":"Dental management of patients receiving oral bisphosphonate therapy: expert panel recommendations.","volume":"137","year":"2006","journal-title":"J Am Dent Assoc"}],"container-title":["Current Opinion in Otolaryngology &amp; Head &amp; Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/MOO.0b013e328304b445","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T17:10:34Z","timestamp":1786036234000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00020840-200808000-00005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.1097\/moo.0b013e328304b445","relation":{},"ISSN":["1068-9508"],"issn-type":[{"value":"1068-9508","type":"print"}],"subject":[],"published":{"date-parts":[[2008,8]]}}}