{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:33:08Z","timestamp":1792175588616,"version":"4.4.0"},"reference-count":77,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,10]]},"DOI":"10.1097\/moo.0b013e32830e20db","type":"journal-article","created":{"date-parts":[[2008,9,16]],"date-time":"2008-09-16T03:15:43Z","timestamp":1221534943000},"page":"472-477","source":"Crossref","is-referenced-by-count":48,"title":["State-of-the-art mechanisms of intracochlear drug delivery"],"prefix":"10.1097","volume":"16","author":[{"given":"David A","family":"Borkholder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-14-20210206","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0030-6665(02)00023-3","article-title":"Chemical perfusion of the inner ear","volume":"35","author":"Jackson","year":"2002","journal-title":"Otolaryngol Clin North Am"},{"key":"R2-14-20210206","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1097\/01.moo.0000134438.91734.38","article-title":"Transtympanic perfusion: indications and limitations","volume":"12","author":"Light","year":"2004","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"R3-14-20210206","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1097\/01.moo.0000244190.51560.6b","article-title":"Delivery of drugs to the inner ear","volume":"14","author":"Hoffer","year":"2006","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"R4-14-20210206","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0079-6123(07)66023-3","article-title":"Drug treatments for tinnitus","volume":"166","author":"Darlington","year":"2007","journal-title":"Prog Brain Res"},{"key":"R5-14-20210206","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1097\/00129492-200211000-00026","article-title":"Analysis of gentamicin kinetics in fluids of the inner ear with round window administration","volume":"23","author":"Plontke","year":"2002","journal-title":"Otol Neurotol"},{"key":"R6-14-20210206","first-page":"564","article-title":"Intratympanic injection of dexamethasone: time course of inner ear distribution and conversion to its active form","volume":"27","author":"Hargunani","year":"2006","journal-title":"Otol Neurotol"},{"key":"R7-14-20210206","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1159\/000095284","article-title":"Simulation of application strategies for local drug delivery to the inner ear","volume":"68","author":"Plontke","year":"2006","journal-title":"ORL J Otorhinolaryngol Relat Spec"},{"key":"R8-14-20210206","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1097\/MLG.0b013e318058a06b","article-title":"Concentration gradient along the scala tympani after local application of gentamicin to the round window membrane","volume":"117","author":"Plontke","year":"2007","journal-title":"Laryngoscope"},{"key":"R9-14-20210206","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1159\/000097246","article-title":"Cochlear pharmacokinetics with local inner ear drug delivery using a three-dimensional finite-element computer model","volume":"12","author":"Plontke","year":"2007","journal-title":"Audiol Neurootol"},{"key":"R10-14-20210206","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1097\/MAO.0b013e318161aaae","article-title":"Dexamethasone concentration gradients along scala tympani after application to the round window membrane","volume":"29","author":"Plontke","year":"2008","journal-title":"Otol Neurotol"},{"key":"R11-14-20210206","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.brainresprot.2003.11.002","article-title":"A model for implanting neuronal tissue into the cochlea","volume":"12","author":"Olivius","year":"2004","journal-title":"Brain Res Brain Res Protoc"},{"key":"R12-14-20210206","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1517\/14712598.4.11.1811","article-title":"Biological therapy for the inner ear","volume":"4","author":"Patel","year":"2004","journal-title":"Expert Opin Biol Ther"},{"key":"R13-14-20210206","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.otc.2004.05.001","article-title":"Drug delivery to the inner ear using gene therapy","volume":"37","author":"Staecker","year":"2004","journal-title":"Otolaryngol Clin North Am"},{"key":"R14-14-20210206","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.2174\/1381612053507530","article-title":"Cell therapy for inner ear diseases","volume":"11","author":"Nakagawa","year":"2005","journal-title":"Curr Pharm Des"},{"key":"R15-14-20210206","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1080\/15216540600913258","article-title":"Sensorineural hearing loss: potential therapies and gene targets for drug development","volume":"58","author":"Tang","year":"2006","journal-title":"IUBMB Life"},{"key":"R16-14-20210206","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1159\/000095896","article-title":"Inner ear therapy for neural preservation","volume":"11","author":"Richardson","year":"2006","journal-title":"Audiol Neurootol"},{"key":"R17-14-20210206","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1097\/01.mlg.0000200791.77819.eb","article-title":"Cochlear protection by local insulin-like growth factor-1 application using biodegradable hydrogel","volume":"116","author":"Iwai","year":"2006","journal-title":"Laryngoscope"},{"key":"R18-14-20210206","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1097\/MAO.0b013e31811f40db","article-title":"Novel therapy for hearing loss: delivery of insulin-like growth factor 1 to the cochlea using gelatin hydrogel","volume":"28","author":"Lee","year":"2007","journal-title":"Otol Neurotol"},{"key":"R19-14-20210206","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1159\/000058300","article-title":"Current issues in cochlear gene transfer","volume":"7","author":"Lalwani","year":"2002","journal-title":"Audiol Neurootol"},{"key":"R20-14-20210206","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/nm1193","article-title":"Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals","volume":"11","author":"Izumikawa","year":"2005","journal-title":"Nat Med"},{"key":"R21-14-20210206","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/MAO.0b013e31802b3225","article-title":"Vestibular hair cell regeneration and restoration of balance function induced by math1 gene transfer","volume":"28","author":"Staecker","year":"2007","journal-title":"Otol Neurotol"},{"key":"R22-14-20210206","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1097\/MAO.0b013e31815aee21","article-title":"Intratympanic versus intravenous delivery of methylprednisolone to cochlear perilymph","volume":"28","author":"Bird","year":"2007","journal-title":"Otol Neurotol"},{"key":"R23-14-20210206","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1097\/01.mao.0000235310.72442.4e","article-title":"Technical note on microcatheter implantation for local inner ear drug delivery: surgical technique and safety aspects","volume":"27","author":"Plontke","year":"2006","journal-title":"Otol Neurotol"},{"key":"R24-14-20210206","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1159\/000095897","article-title":"Local perfusion of the tumor necrosis factor alpha blocker infliximab to the inner ear improves autoimmune neurosensory hearing loss","volume":"11","author":"Van Wijk","year":"2006","journal-title":"Audiol Neurootol"},{"key":"R25-14-20210206","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.otc.2004.04.005","article-title":"Sustained-release devices in inner ear medical therapy","volume":"37","author":"Hoffer","year":"2004","journal-title":"Otolaryngol Clin North Am"},{"key":"R26-14-20210206","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1097\/00005537-200108000-00007","article-title":"Transtympanic versus sustained-release administration of gentamicin: kinetics, morphology, and function","volume":"111","author":"Hoffer","year":"2001","journal-title":"Laryngoscope"},{"key":"R27-14-20210206","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1080\/00016480510026881","article-title":"Cochlear hair cell loss in single-dose versus continuous round window administration of gentamicin","volume":"125","author":"Wagner","year":"2005","journal-title":"Acta Otolaryngol"},{"key":"R28-14-20210206","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1097\/00020840-200310000-00005","article-title":"Inner ear perfusion: indications and applications","volume":"11","author":"Hoffmann","year":"2003","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"R29-14-20210206","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.heares.2007.04.005","article-title":"Gentamicin uptake in the chinchilla inner ear","volume":"230","author":"Roehm","year":"2007","journal-title":"Hear Res"},{"key":"R30-14-20210206","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1080\/00016480600794438","article-title":"Pattern of cochlear damage caused by short-term kanamycin application using the round window microcatheter method","volume":"127","author":"Hashimoto","year":"2007","journal-title":"Acta Otolaryngol"},{"key":"R31-14-20210206","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.heares.2006.05.006","article-title":"AM-111 protects against permanent hearing loss from impulse noise trauma","volume":"226","author":"Coleman","year":"2007","journal-title":"Hear Res"},{"key":"R32-14-20210206","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1080\/03655230601065332","article-title":"Drug delivery systems for the treatment of sensorineural hearing loss","volume":"557","author":"Nakagawa","year":"2007","journal-title":"Acta Otolaryngol Suppl"},{"key":"R33-14-20210206","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.otohns.2004.05.021","article-title":"Direct round window application of gentamicin with varying delivery vehicles: a comparison of ototoxicity","volume":"131","author":"Sheppard","year":"2004","journal-title":"Otolaryngol Head Neck Surg"},{"key":"R34-14-20210206","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1097\/MLG.0b013e31815f8e41","article-title":"A novel controlled local drug delivery system for inner ear disease","volume":"118","author":"Paulson","year":"2008","journal-title":"Laryngoscope"},{"key":"R35-14-20210206","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1097\/01.mlg.0000180174.81036.5a","article-title":"Drug delivery to the cochlea using PLGA nanoparticles","volume":"115","author":"Tamura","year":"2005","journal-title":"Laryngoscope"},{"key":"R36-14-20210206","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.otohns.2007.04.013","article-title":"Distribution of PLGA nanoparticles in chinchilla cochleae","volume":"137","author":"Ge","year":"2007","journal-title":"Otolaryngol Head Neck Surg"},{"key":"R37-14-20210206","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1080\/00016480600895102","article-title":"Transsynaptic delivery of nanoparticles to the central auditory nervous system","volume":"127","author":"Praetorius","year":"2007","journal-title":"Acta Otolaryngol"},{"key":"R39-14-20210206","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1080\/000164801300043307","article-title":"Gene expression in the mammalian cochlea: a study of multiple vector systems","volume":"121","author":"Staecker","year":"2001","journal-title":"Acta Otolaryngol"},{"key":"R40-14-20210206","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0378-5955(02)00579-8","article-title":"Gene transfer into supporting cells of the organ of Corti","volume":"173","author":"Ishimoto","year":"2002","journal-title":"Hear Res"},{"key":"R41-14-20210206","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1089\/10430349950018526","article-title":"Inner ear transgene expression after adenoviral vector inoculation in the endolymphatic sac","volume":"10","author":"Yamasoba","year":"1999","journal-title":"Hum Gene Ther"},{"key":"R42-14-20210206","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1006\/mthe.2001.0490","article-title":"The functional and structural outcome of inner ear gene transfer via the vestibular and cochlear fluids in mice","volume":"4","author":"Kawamoto","year":"2001","journal-title":"Mol Ther"},{"key":"R43-14-20210206","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1038\/sj.gt.3301180","article-title":"Effect of transgenic GDNF expression on gentamicin-induced cochlear and vestibular toxicity","volume":"7","author":"Suzuki","year":"2000","journal-title":"Gene Ther"},{"key":"R44-14-20210206","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1006\/mthe.2002.0627","article-title":"Neurotrophin-3 transduction attenuates cisplatin spiral ganglion neuron ototoxicity in the cochlea","volume":"6","author":"Bowers","year":"2002","journal-title":"Mol Ther"},{"key":"R45-14-20210206","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0165-0270(92)90050-N","article-title":"Chronic drug infusion into the scala tympani of the guinea pig cochlea","volume":"45","author":"Kingma","year":"1992","journal-title":"J Neurosci Methods"},{"key":"R46-14-20210206","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0378-5955(93)90155-T","article-title":"Osmotic pump implant for chronic infusion of drugs into the inner ear","volume":"70","author":"Brown","year":"1993","journal-title":"Hear Res"},{"key":"R47-14-20210206","first-page":"304","article-title":"Enhanced preservation of the auditory nerve following cochlear perfusion with nerve growth factors","volume":"16","author":"Schindler","year":"1995","journal-title":"Am J Otol"},{"key":"R48-14-20210206","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nm0496-463","article-title":"Protection of auditory neurons from aminoglycoside toxicity by neurotrophin-3","volume":"2","author":"Ernfors","year":"1996","journal-title":"Nat Med"},{"key":"R49-14-20210206","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0378-5955(97)00151-2","article-title":"Green fluorescent protein as a reporter for gene transfer studies in the cochlea","volume":"114","author":"Lalwani","year":"1997","journal-title":"Hear Res"},{"key":"R50-14-20210206","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0194-5998(98)70194-9","article-title":"Brain-derived neurotrophic factor gene therapy prevents spiral ganglion degeneration after hair cell loss","volume":"119","author":"Staecker","year":"1998","journal-title":"Otolaryngol Head Neck Surg"},{"key":"R51-14-20210206","first-page":"87","article-title":"The effect of cochleostomy and intracochlear infusion on auditory brain stem response threshold in the guinea pig","volume":"20","author":"Carvalho","year":"1999","journal-title":"Am J Otol"},{"key":"R52-14-20210206","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/S0378-5955(99)00193-8","article-title":"Technical report: chronic and acute intracochlear infusion in rodents","volume":"140","author":"Prieskorn","year":"2000","journal-title":"Hear Res"},{"key":"R53-14-20210206","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/sj.gt.3301445","article-title":"A modified adenovirus can transfect cochlear hair cells in vivo without compromising cochlear function","volume":"8","author":"Luebke","year":"2001","journal-title":"Gene Ther"},{"key":"R54-14-20210206","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0306-4522(02)00004-0","article-title":"Riluzole rescues cochlear sensory cells from acoustic trauma in the guinea-pig","volume":"111","author":"Wang","year":"2002","journal-title":"Neuroscience"},{"key":"R55-14-20210206","doi-asserted-by":"crossref","first-page":"8596","DOI":"10.1523\/JNEUROSCI.23-24-08596.2003","article-title":"A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss","volume":"23","author":"Wang","year":"2003","journal-title":"J Neurosci"},{"key":"R56-14-20210206","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/S0028-3908(03)00194-1","article-title":"Local application of sodium thiosulfate prevents cisplatin-induced hearing loss in the guinea pig","volume":"45","author":"Wang","year":"2003","journal-title":"Neuropharmacology"},{"key":"R57-14-20210206","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0014-2999(03)01367-0","article-title":"Protective effect of edaravone against streptomycin-induced vestibulotoxicity in the guinea pig","volume":"464","author":"Horiike","year":"2003","journal-title":"Eur J Pharmacol"},{"key":"R58-14-20210206","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.ymthe.2003.11.020","article-title":"Antioxidant gene therapy can protect hearing and hair cells from ototoxicity","volume":"9","author":"Kawamoto","year":"2004","journal-title":"Mol Ther"},{"key":"R59-14-20210206","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ejphar.2004.01.019","article-title":"The clinical free radical scavenger, edaravone, protects cochlear hair cells from acoustic trauma","volume":"487","author":"Takemoto","year":"2004","journal-title":"Eur J Pharmacol"},{"key":"R60-14-20210206","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1097\/01.mao.0000185063.20081.50","article-title":"Exogenous BDNF rescues rat spiral ganglion neurons in vivo","volume":"26","author":"McGuinness","year":"2005","journal-title":"Otol Neurotol"},{"key":"R61-14-20210206","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jneumeth.2005.05.017","article-title":"A method for intracochlear drug delivery in the mouse","volume":"150","author":"Chen","year":"2006","journal-title":"J Neurosci Methods"},{"key":"R62-14-20210206","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1016\/j.neuropharm.2007.02.007","article-title":"A novel dual inhibitor of calpains and lipid peroxidation (BN82270) rescues the cochlea from sound trauma","volume":"52","author":"Wang","year":"2007","journal-title":"Neuropharmacology"},{"key":"R63-14-20210206","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1097\/MAO.0b013e31805778fc","article-title":"Local dexamethasone therapy conserves hearing in an animal model of electrode insertion trauma-induced hearing loss","volume":"28","author":"Eshraghi","year":"2007","journal-title":"Otol Neurotol"},{"key":"R64-14-20210206","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1002\/jnr.21320","article-title":"Delayed neurotrophin treatment following deafness rescues spiral ganglion cells from death and promotes regrowth of auditory nerve peripheral processes: effects of brain-derived neurotrophic factor and fibroblast growth factor","volume":"85","author":"Miller","year":"2007","journal-title":"J Neurosci Res"},{"key":"R65-14-20210206","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S0378-5955(02)00517-8","article-title":"A multichannel scala tympani electrode array incorporating a drug delivery system for chronic intracochlear infusion","volume":"172","author":"Shepherd","year":"2002","journal-title":"Hear Res"},{"key":"R66-14-20210206","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jneumeth.2007.05.013","article-title":"Design and fabrication of multichannel cochlear implants for animal research","volume":"166","author":"Rebscher","year":"2007","journal-title":"J Neurosci Methods"},{"key":"R67-14-20210206","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.heares.2005.10.013","article-title":"Substance distribution in a cochlea model using different pump rates for cochlear implant drug delivery electrode prototypes","volume":"212","author":"Paasche","year":"2006","journal-title":"Hear Res"},{"key":"R68-14-20210206","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1179\/cim.2007.8.1.38","article-title":"Development of a drug delivery device: using the femtosecond laser to modify cochlear implant electrodes","volume":"8","author":"St\u00f6ver","year":"2007","journal-title":"Cochlear Implants Int"},{"key":"R69-14-20210206","first-page":"37","article-title":"Gene-based therapy for inner ear disease","volume":"3","author":"Kawamoto","year":"2001","journal-title":"Noise Health"},{"key":"R70-14-20210206","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1159\/000077264","article-title":"Adenovirus-mediated expression of brain-derived neurotrophic factor protects spiral ganglion neurons from ototoxic damage","volume":"9","author":"Nakaizumi","year":"2004","journal-title":"Audiol Neurootol"},{"key":"R71-14-20210206","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/sj.mt.6300379","article-title":"Protection against aminoglycoside-induced ototoxicity by regulated AAV vector-mediated GDNF gene transfer into the cochlea","volume":"16","author":"Liu","year":"2008","journal-title":"Mol Ther"},{"key":"R72-14-20210206","doi-asserted-by":"crossref","first-page":"4395","DOI":"10.1523\/JNEUROSCI.23-11-04395.2003","article-title":"Math1 gene transfer generates new cochlear hair cells in mature guinea pigs in vivo","volume":"23","author":"Kawamoto","year":"2003","journal-title":"J Neurosci"},{"key":"R73-14-20210206","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.heares.2006.07.002","article-title":"Pharmacodynamics of adenovector distribution within the inner ear tissues of the mouse","volume":"227","author":"Praetorius","year":"2007","journal-title":"Hearing Res"},{"key":"R74-14-20210206","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.ymthe.2005.03.021","article-title":"Specific and efficient transduction of Cochlear inner hair cells with recombinant adeno-associated virus type 3 vector","volume":"12","author":"Liu","year":"2005","journal-title":"Mol Ther"},{"key":"R75-14-20210206","first-page":"277","article-title":"Pharmacokinetics of drug entry into cochlear fluids","volume":"105","author":"Salt","year":"2005","journal-title":"Volta Rev"},{"key":"R76-14-20210206","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1097\/01.aud.0000233864.32183.81","article-title":"Perilymph\/modiolar communication routes in the human cochlea","volume":"27","author":"Rask-Andersen","year":"2006","journal-title":"Ear Hear"},{"key":"R77-14-20210206","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/sj.gt.3301108","article-title":"Transduction of the contralateral ear after adenovirus-mediated cochlear gene transfer","volume":"7","author":"St\u00f6ver","year":"2000","journal-title":"Gene Ther"},{"key":"R78-14-20210206","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2005.09.003","article-title":"Inner ear drug delivery via a reciprocating perfusion system in the guinea pig","volume":"110","author":"Chen","year":"2005","journal-title":"J Control Release"}],"container-title":["Current Opinion in Otolaryngology &amp; Head &amp; Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/MOO.0b013e32830e20db","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T00:18:58Z","timestamp":1620951538000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00020840-200810000-00014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":77,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.1097\/moo.0b013e32830e20db","relation":{},"ISSN":["1068-9508"],"issn-type":[{"value":"1068-9508","type":"print"}],"subject":[],"published":{"date-parts":[[2008,10]]}}}