{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T03:41:37Z","timestamp":1789530097186,"version":"build-2803163510"},"reference-count":62,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,10]]},"DOI":"10.1097\/moo.0b013e3283303347","type":"journal-article","created":{"date-parts":[[2009,9,15]],"date-time":"2009-09-15T07:15:49Z","timestamp":1252998949000},"page":"381-387","source":"Crossref","is-referenced-by-count":32,"title":["Regulation of cell fate and patterning in the developing mammalian cochlea"],"prefix":"10.1097","volume":"17","author":[{"given":"Matthew W","family":"Kelley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth C","family":"Driver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandrakala","family":"Puligilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-10-20210206","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.jcomdis.2008.03.004","article-title":"Genetic and pharmacological intervention for treatment\/prevention of hearing loss","volume":"41","author":"Cotanche","year":"2008","journal-title":"J Commun Disord"},{"key":"R2-10-20210206","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1097\/MOO.0b013e32830f4ab5","article-title":"Recent advances in hair cell regeneration research","volume":"16","author":"Collado","year":"2008","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"R3-10-20210206","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s007950070001","article-title":"Potassium ion recycling pathway via gap junction systems in the mammalian cochlea and its interruption in hereditary nonsyndromic deafness","volume":"33","author":"Kikuchi","year":"2000","journal-title":"Med Electron Microsc"},{"key":"R4-10-20210206","doi-asserted-by":"crossref","first-page":"4119","DOI":"10.1242\/dev.01339","article-title":"From placode to polarization: new tunes in inner ear development","volume":"131","author":"Barald","year":"2004","journal-title":"Development"},{"key":"R5-10-20210206","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/nrn1987","article-title":"Regulation of cell fate in the sensory epithelia of the inner ear","volume":"7","author":"Kelley","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"R6-10-20210206","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.devcel.2008.11.010","article-title":"Hedgehog signaling in development and cancer","volume":"15","author":"Jiang","year":"2008","journal-title":"Dev Cell"},{"key":"R7-10-20210206","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1101\/gad.1013302","article-title":"Specification of the mammalian cochlea is dependent on Sonic hedgehog","volume":"16","author":"Riccomagno","year":"2002","journal-title":"Genes Dev"},{"key":"R8-10-20210206","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/ng0397-266","article-title":"GLI3 frameshift mutations cause autosomal dominant Pallister-Hall syndrome","volume":"15","author":"Kang","year":"1997","journal-title":"Nat Genet"},{"key":"R9-10-20210206","doi-asserted-by":"crossref","first-page":"7350","DOI":"10.1523\/JNEUROSCI.0312-08.2008","article-title":"Hedgehog signaling regulates sensory cell formation and auditory function in mice and humans","volume":"28","author":"Driver","year":"2008","journal-title":"J Neurosci"},{"key":"R10-10-20210206","first-page":"2442","article-title":"Mutations within Sox2\/SOX2 are associated with abnormalities in the hypothalamo-pituitary-gonadal axis in mice and humans","volume":"116","author":"Kelberman","year":"2006","journal-title":"J Clin Invest"},{"key":"R11-10-20210206","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1038\/nature03487","article-title":"Sox2 is required for sensory organ development in the mammalian inner ear","volume":"434","author":"Kiernan","year":"2005","journal-title":"Nature"},{"key":"R12-10-20210206","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.modgep.2007.05.002","article-title":"Expression of LHX3 and SOX2 during mouse inner ear development","volume":"7","author":"Hume","year":"2007","journal-title":"Gene Expr Patterns"},{"key":"R14-10-20210206","doi-asserted-by":"crossref","first-page":"18396","DOI":"10.1073\/pnas.0808175105","article-title":"Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochlea","volume":"105","author":"Dabdoub","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R15-10-20210206","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/cne.20944","article-title":"Expression of Prox1 during mouse cochlear development","volume":"496","author":"Bermingham-McDonogh","year":"2006","journal-title":"J Comp Neurol"},{"key":"R16-10-20210206","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ydbio.2008.07.004","article-title":"Prox1 interacts with Atoh1 and Gfi1, and regulates cellular differentiation in the inner ear sensory epithelia","volume":"322","author":"Kirjavainen","year":"2008","journal-title":"Dev Biol"},{"key":"R17-10-20210206","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0896-6273(02)00824-3","article-title":"FGFR1 is required for the development of the auditory sensory epithelium","volume":"35","author":"Pirvola","year":"2002","journal-title":"Neuron"},{"key":"R18-10-20210206","doi-asserted-by":"crossref","first-page":"5991","DOI":"10.1523\/JNEUROSCI.1690-08.2008","article-title":"Fgf20 is required for sensory epithelial specification in the developing cochlea","volume":"28","author":"Hayashi","year":"2008","journal-title":"J Neurosci"},{"key":"R19-10-20210206","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s101620010023","article-title":"Expression of Math1 and HES5 in the cochleae of wildtype and Jag2 mutant mice","volume":"1","author":"Lanford","year":"2000","journal-title":"J Assoc Res Otolaryngol"},{"key":"R20-10-20210206","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1126\/science.284.5421.1837","article-title":"Math1: an essential gene for the generation of inner ear hair cells","volume":"284","author":"Bermingham","year":"1999","journal-title":"Science"},{"key":"R21-10-20210206","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/nm1193","article-title":"Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals","volume":"11","author":"Izumikawa","year":"2005","journal-title":"Nat Med"},{"key":"R22-10-20210206","doi-asserted-by":"crossref","first-page":"4395","DOI":"10.1523\/JNEUROSCI.23-11-04395.2003","article-title":"Math1 gene transfer generates new cochlear hair cells in mature guinea pigs in vivo","volume":"23","author":"Kawamoto","year":"2003","journal-title":"J Neurosci"},{"key":"R23-10-20210206","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1038\/nn1349","article-title":"Math1 regulates development of the sensory epithelium in the mammalian cochlea","volume":"7","author":"Woods","year":"2004","journal-title":"Nat Neurosci"},{"key":"R24-10-20210206","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/75753","article-title":"Overexpression of Math1 induces robust production of extra hair cells in postnatal rat inner ears","volume":"3","author":"Zheng","year":"2000","journal-title":"Nat Neurosci"},{"key":"R25-10-20210206","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/MAO.0b013e31802b3225","article-title":"Vestibular hair cell regeneration and restoration of balance function induced by math1 gene transfer","volume":"28","author":"Staecker","year":"2007","journal-title":"Otol Neurotol"},{"key":"R26-10-20210206","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/nature07265","article-title":"Functional auditory hair cells produced in the mammalian cochlea by in utero gene transfer","volume":"455","author":"Gubbels","year":"2008","journal-title":"Nature"},{"key":"R27-10-20210206","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1242\/dev.02284","article-title":"Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear","volume":"133","author":"Brooker","year":"2006","journal-title":"Development"},{"key":"R28-10-20210206","doi-asserted-by":"crossref","first-page":"4353","DOI":"10.1242\/dev.02002","article-title":"The notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear","volume":"132","author":"Kiernan","year":"2005","journal-title":"Development"},{"key":"R29-10-20210206","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/6804","article-title":"Notch signalling pathway mediates hair cell development in mammalian cochlea","volume":"21","author":"Lanford","year":"1999","journal-title":"Nat Genet"},{"key":"R30-10-20210206","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.devcel.2008.11.008","article-title":"Hey2 regulation by FGF provides a notch-independent mechanism for maintaining pillar cell fate in the organ of Corti","volume":"16","author":"Doetzlhofer","year":"2009","journal-title":"Dev Cell"},{"key":"R31-10-20210206","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1471-213X-8-20","article-title":"Hey2 functions in parallel with Hes1 and Hes5 for mammalian auditory sensory organ development","volume":"8","author":"Li","year":"2008","journal-title":"BMC Dev Biol"},{"key":"R32-10-20210206","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ydbio.2008.01.006","article-title":"Hesr1 and Hesr2 may act as early effectors of notch signaling in the developing cochlea","volume":"316","author":"Hayashi","year":"2008","journal-title":"Dev Biol"},{"key":"R33-10-20210206","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1006\/dbio.1993.1040","article-title":"Unique expression pattern of the FGF receptor 3 gene during mouse organogenesis","volume":"155","author":"Peters","year":"1993","journal-title":"Dev Biol"},{"key":"R34-10-20210206","doi-asserted-by":"crossref","first-page":"9269","DOI":"10.1073\/pnas.92.20.9269","article-title":"The site of action of neuronal acidic fibroblast growth factor is the organ of Corti of the rat cochlea","volume":"92","author":"Pirvola","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R35-10-20210206","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1242\/dev.02874","article-title":"Fgf8 induces pillar cell fate and regulates cellular patterning in the mammalian cochlea","volume":"134","author":"Jacques","year":"2007","journal-title":"Development"},{"key":"R36-10-20210206","doi-asserted-by":"crossref","first-page":"9368","DOI":"10.1523\/JNEUROSCI.22-21-09368.2002","article-title":"Fibroblast growth factor signaling regulates pillar cell development in the organ of Corti","volume":"22","author":"Mueller","year":"2002","journal-title":"J Neurosci"},{"key":"R37-10-20210206","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/ng0496-390","article-title":"Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3","volume":"12","author":"Colvin","year":"1996","journal-title":"Nat Genet"},{"key":"R38-10-20210206","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1002\/dvdy.21192","article-title":"Disruption of fibroblast growth factor receptor 3 signaling results in defects in cellular differentiation, neuronal patterning, and hearing impairment","volume":"236","author":"Puligilla","year":"2007","journal-title":"Dev Dyn"},{"key":"R39-10-20210206","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/dvdy.21026","article-title":"Loss of Fgfr3 leads to excess hair cell development in the mouse organ of Corti","volume":"236","author":"Hayashi","year":"2007","journal-title":"Dev Dyn"},{"key":"R40-10-20210206","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/S0140-6736(98)24012-8","article-title":"Deafness due to Pro250Arg mutation of FGFR3","volume":"351","author":"Hollway","year":"1998","journal-title":"Lancet"},{"key":"R41-10-20210206","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/hmg\/ddn311","article-title":"Hearing loss in a mouse model of Muenke syndrome","volume":"18","author":"Mansour","year":"2009","journal-title":"Hum Mol Genet"},{"key":"R42-10-20210206","first-page":"555","article-title":"A unique point mutation in the fibroblast growth factor receptor 3 gene (FGFR3) defines a new craniosynostosis syndrome","volume":"60","author":"Muenke","year":"1997","journal-title":"Am J Hum Genet"},{"key":"R43-10-20210206","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.bbadis.2008.11.010","article-title":"Activating Fgfr3 Y367C mutation causes hearing loss and inner ear defect in a mouse model of chondrodysplasia","volume":"1792","author":"Pannier","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"R44-10-20210206","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1086\/508433","article-title":"A novel mutation in FGFR3 causes camptodactyly, tall stature, and hearing loss (CATSHL) syndrome","volume":"79","author":"Toydemir","year":"2006","journal-title":"Am J Hum Genet"},{"key":"R45-10-20210206","doi-asserted-by":"crossref","first-page":"6633","DOI":"10.1523\/JNEUROSCI.1280-08.2008","article-title":"Jxc1\/Sobp, encoding a nuclear zinc finger protein, is critical for cochlear growth, cell fate, and patterning of the organ of Corti","volume":"28","author":"Chen","year":"2008","journal-title":"J Neurosci"},{"key":"R46-10-20210206","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/nature01618","article-title":"Identification of Vangl2 and Scrb1 as planar polarity genes in mammals","volume":"423","author":"Montcouquiol","year":"2003","journal-title":"Nature"},{"key":"R47-10-20210206","doi-asserted-by":"crossref","first-page":"e1000259","DOI":"10.1371\/journal.pgen.1000259","article-title":"Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development","volume":"4","author":"Etheridge","year":"2008","journal-title":"PLoS Genet"},{"key":"R48-10-20210206","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1242\/dev.02347","article-title":"Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation","volume":"133","author":"Wang","year":"2006","journal-title":"Development"},{"key":"R49-10-20210206","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/ng.2007.54","article-title":"Ciliary proteins link basal body polarization to planar cell polarity regulation","volume":"40","author":"Jones","year":"2008","journal-title":"Nat Genet"},{"key":"R50-10-20210206","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0070-2153(08)00808-9","article-title":"Primary cilia in planar cell polarity regulation of the inner ear","volume":"85","author":"Jones","year":"2008","journal-title":"Curr Top Dev Biol"},{"key":"R51-10-20210206","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1146\/annurev.genet.42.110807.091432","article-title":"Planar cell polarity signaling: from fly development to human disease","volume":"42","author":"Simons","year":"2008","journal-title":"Annu Rev Genet"},{"key":"R52-10-20210206","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.neuron.2008.09.003","article-title":"The plane facts of PCP in the CNS","volume":"60","author":"Goodrich","year":"2008","journal-title":"Neuron"},{"key":"R53-10-20210206","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.cub.2005.03.040","article-title":"Planar cell polarity genes regulate polarized extracellular matrix deposition during frog gastrulation","volume":"15","author":"Goto","year":"2005","journal-title":"Curr Biol"},{"key":"R54-10-20210206","doi-asserted-by":"crossref","first-page":"4037","DOI":"10.1242\/dev.00567","article-title":"Prickle 1 regulates cell movements during gastrulation and neuronal migration in zebrafish","volume":"130","author":"Carreira-Barbosa","year":"2003","journal-title":"Development"},{"key":"R55-10-20210206","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1242\/dev.026542","article-title":"Flamingo regulates epiboly and convergence\/extension movements through cell cohesive and signalling functions during zebrafish gastrulation","volume":"136","author":"Carreira-Barbosa","year":"2009","journal-title":"Development"},{"key":"R56-10-20210206","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/dvdy.10500","article-title":"Cellular growth and rearrangement during the development of the mammalian organ of Corti","volume":"229","author":"McKenzie","year":"2004","journal-title":"Dev Dyn"},{"key":"R57-10-20210206","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1242\/dev.129.10.2495","article-title":"The role of Math1 in inner ear development: Uncoupling the establishment of the sensory primordium from hair cell fate determination","volume":"129","author":"Chen","year":"2002","journal-title":"Development"},{"key":"R58-10-20210206","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/nature02590","article-title":"Myosin-dependent junction remodelling controls planar cell intercalation and axis elongation","volume":"429","author":"Bertet","year":"2004","journal-title":"Nature"},{"key":"R59-10-20210206","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1086\/383285","article-title":"Nonmuscle myosin heavy-chain gene MYH14 is expressed in cochlea and mutated in patients affected by autosomal dominant hearing impairment (DFNA4)","volume":"74","author":"Donaudy","year":"2004","journal-title":"Am J Hum Genet"},{"key":"R60-10-20210206","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1086\/324267","article-title":"Nonmuscle myosin heavy chain II A mutations define a spectrum of autosomal dominant macrothrombocytopenias: May-Hegglin anomaly and Fechtner, Sebastian, Epstein, and Alport-like syndromes","volume":"69","author":"Heath","year":"2001","journal-title":"Am J Hum Genet"},{"key":"R61-10-20210206","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1086\/321212","article-title":"Human nonsyndromic hereditary deafness DFNA17 is due to a mutation in nonmuscle myosin MYH9","volume":"67","author":"Lalwani","year":"2000","journal-title":"Am J Hum Genet"},{"key":"R62-10-20210206","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/ajmg.a.30989","article-title":"Genetic heterogeneity of deafness phenotypes linked to DFNA4","volume":"139","author":"Yang","year":"2005","journal-title":"Am J Med Genet A"},{"key":"R63-10-20210206","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1242\/dev.030718","article-title":"Myosin II regulates extension, growth and patterning in the mammalian cochlear duct","volume":"136","author":"Yamamoto","year":"2009","journal-title":"Development"}],"container-title":["Current Opinion in Otolaryngology & Head & Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/MOO.0b013e3283303347","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T18:51:58Z","timestamp":1633891918000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00020840-200910000-00010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":62,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1097\/moo.0b013e3283303347","relation":{},"ISSN":["1068-9508"],"issn-type":[{"value":"1068-9508","type":"print"}],"subject":[],"published":{"date-parts":[[2009,10]]}}}