{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:34:36Z","timestamp":1791959676044,"version":"4.3.4"},"reference-count":60,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,10]]},"DOI":"10.1097\/moo.0b013e3283303472","type":"journal-article","created":{"date-parts":[[2009,9,15]],"date-time":"2009-09-15T07:15:49Z","timestamp":1252998949000},"page":"388-393","source":"Crossref","is-referenced-by-count":67,"title":["Tip links in hair cells: molecular composition and role in hearing loss"],"prefix":"10.1097","volume":"17","author":[{"given":"Hirofumi","family":"Sakaguchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Tokita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bechara","family":"Kachar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-11-20210206","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nature06091","article-title":"Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells","volume":"449","author":"Kazmierczak","year":"2007","journal-title":"Nature"},{"key":"R2-11-20210206","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/nature02483","article-title":"Cadherin 23 is a component of the tip link in hair-cell stereocilia","volume":"428","author":"Siemens","year":"2004","journal-title":"Nature"},{"key":"R3-11-20210206","doi-asserted-by":"crossref","first-page":"7022","DOI":"10.1523\/JNEUROSCI.1163-06.2006","article-title":"The tip-link antigen, a protein associated with the transduction complex of sensory hair cells, is protocadherin-15","volume":"26","author":"Ahmed","year":"2006","journal-title":"J Neurosci"},{"key":"R4-11-20210206","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s00232-005-0834-8","article-title":"Mechano-electrical transduction: new insights into old ideas","volume":"209","author":"Ricci","year":"2006","journal-title":"J Membr Biol"},{"key":"R5-11-20210206","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0378-5955(84)90041-8","article-title":"Cross-links between stereocilia in the guinea pig organ of Corti, and their possible relation to sensory transduction","volume":"15","author":"Pickles","year":"1984","journal-title":"Hear Res"},{"key":"R6-11-20210206","doi-asserted-by":"crossref","first-page":"13336","DOI":"10.1073\/pnas.97.24.13336","article-title":"High-resolution structure of hair-cell tip links","volume":"97","author":"Kachar","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R7-11-20210206","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1146\/annurev.physiol.66.032102.112842","article-title":"Myosin-1c, the hair cell's adaptation motor","volume":"66","author":"Gillespie","year":"2004","journal-title":"Annu Rev Physiol"},{"key":"R8-11-20210206","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.neuron.2005.07.024","article-title":"Fast adaptation in vestibular hair cells requires myosin-1c activity","volume":"47","author":"Stauffer","year":"2005","journal-title":"Neuron"},{"key":"R9-11-20210206","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1007\/s101620010010","article-title":"Helical structure of hair cell stereocilia tip links in the chinchilla cochlea","volume":"1","author":"Tsuprun","year":"2000","journal-title":"J Assoc Res Otolaryngol"},{"key":"R10-11-20210206","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/0896-6273(91)90343-X","article-title":"Tip-link integrity and mechanical transduction in vertebrate hair cells","volume":"7","author":"Assad","year":"1991","journal-title":"Neuron"},{"key":"R11-11-20210206","doi-asserted-by":"crossref","first-page":"4878","DOI":"10.1523\/JNEUROSCI.23-12-04878.2003","article-title":"A novel antigen sensitive to calcium chelation that is associated with the tip links and kinocilial links of sensory hair bundles","volume":"23","author":"Goodyear","year":"2003","journal-title":"J Neurosci"},{"key":"R12-11-20210206","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1038\/nature02484","article-title":"Mutations in cadherin 23 affect tip links in zebrafish sensory hair cells","volume":"428","author":"Sollner","year":"2004","journal-title":"Nature"},{"key":"R13-11-20210206","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1093\/hmg\/10.16.1709","article-title":"Mutations in the novel protocadherin PCDH15 cause Usher syndrome type 1F","volume":"10","author":"Alagramam","year":"2001","journal-title":"Hum Mol Genet"},{"key":"R14-11-20210206","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1086\/321277","article-title":"Mutations of the protocadherin gene PCDH15 cause Usher syndrome type 1F","volume":"69","author":"Ahmed","year":"2001","journal-title":"Am J Hum Genet"},{"key":"R15-11-20210206","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1086\/316954","article-title":"Usher syndrome 1D and nonsyndromic autosomal recessive deafness DFNB12 are caused by allelic mutations of the novel cadherin-like gene CDH23","volume":"68","author":"Bork","year":"2001","journal-title":"Am J Hum Genet"},{"key":"R16-11-20210206","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/83667","article-title":"Mutation of CDH23, encoding a new member of the cadherin gene family, causes Usher syndrome type 1D","volume":"27","author":"Bolz","year":"2001","journal-title":"Nat Genet"},{"key":"R17-11-20210206","doi-asserted-by":"crossref","first-page":"3215","DOI":"10.1093\/hmg\/ddg358","article-title":"PCDH15 is expressed in the neurosensory epithelium of the eye and ear and mutant alleles are responsible for both USH1F and DFNB23","volume":"12","author":"Ahmed","year":"2003","journal-title":"Hum Mol Genet"},{"key":"R18-11-20210206","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/83837","article-title":"The mouse Ames waltzer hearing-loss mutant is caused by mutation of Pcdh15, a novel protocadherin gene","volume":"27","author":"Alagramam","year":"2001","journal-title":"Nat Genet"},{"key":"R19-11-20210206","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/83660","article-title":"Mutations in Cdh23, encoding a new type of cadherin, cause stereocilia disorganization in waltzer, the mouse model for Usher syndrome type 1D","volume":"27","author":"Di Palma","year":"2001","journal-title":"Nat Genet"},{"key":"R20-11-20210206","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1538\/expanim.58.1","article-title":"Characterization of the Kyoto circling (KCI) rat carrying a spontaneous nonsense mutation in the protocadherin 15 (Pcdh15) gene","volume":"58","author":"Naoi","year":"2009","journal-title":"Exp Anim"},{"key":"R21-11-20210206","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.ydbio.2005.01.014","article-title":"Cadherin 23 is a component of the transient lateral links in the developing hair bundles of cochlear sensory cells","volume":"280","author":"Michel","year":"2005","journal-title":"Dev Biol"},{"key":"R22-11-20210206","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.ydbio.2005.01.015","article-title":"Spatiotemporal pattern and isoforms of cadherin 23 in wild type and waltzer mice during inner ear hair cell development","volume":"280","author":"Lagziel","year":"2005","journal-title":"Dev Biol"},{"key":"R23-11-20210206","doi-asserted-by":"crossref","first-page":"4106","DOI":"10.1529\/biophysj.104.049031","article-title":"The structure of tip links and kinocilial links in avian sensory hair bundles","volume":"87","author":"Tsuprun","year":"2004","journal-title":"Biophys J"},{"key":"R24-11-20210206","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.neuroscience.2008.02.010","article-title":"The dimensions and structural attachments of tip links in mammalian cochlear hair cells and the effects of exposure to different levels of extracellular calcium","volume":"154","author":"Furness","year":"2008","journal-title":"Neuroscience"},{"key":"R25-11-20210206","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s10162-008-0114-2","article-title":"Three-dimensional architecture of hair-bundle linkages revealed by electron-microscopic tomography","volume":"9","author":"Auer","year":"2008","journal-title":"J Assoc Res Otolaryngol"},{"key":"R26-11-20210206","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.neuroscience.2008.10.012","article-title":"Presence of interstereocilial links in waltzer mutants suggests Cdh23 is not essential for tip link formation","volume":"158","author":"Rzadzinska","year":"2009","journal-title":"Neuroscience"},{"key":"R27-11-20210206","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.ygeno.2007.06.007","article-title":"Promoter, alternative splice forms, and genomic structure of protocadherin 15","volume":"90","author":"Alagramam","year":"2007","journal-title":"Genomics"},{"key":"R28-11-20210206","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/0896-6273(95)90010-1","article-title":"Calcium imaging of single stereocilia in hair cells: localization of transduction channels at both ends of tip links","volume":"15","author":"Denk","year":"1995","journal-title":"Neuron"},{"key":"R29-11-20210206","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nn.2295","article-title":"Localization of inner hair cell mechanotransducer channels using high-speed calcium imaging","volume":"12","author":"Beurg","year":"2009","journal-title":"Nat Neurosci"},{"key":"R30-11-20210206","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/ncb1851","article-title":"Myosin IIIa boosts elongation of stereocilia by transporting espin 1 to the plus ends of actin filaments","volume":"11","author":"Salles","year":"2009","journal-title":"Nat Cell Biol"},{"key":"R31-11-20210206","doi-asserted-by":"crossref","first-page":"6478","DOI":"10.1523\/JNEUROSCI.0342-07.2007","article-title":"Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning","volume":"27","author":"Michalski","year":"2007","journal-title":"J Neurosci"},{"key":"R32-11-20210206","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1083\/jcb.200310055","article-title":"An actin molecular treadmill and myosins maintain stereocilia functional architecture and self-renewal","volume":"164","author":"Rzadzinska","year":"2004","journal-title":"J Cell Biol"},{"key":"R33-11-20210206","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.str.2005.03.001","article-title":"In search of the hair-cell gating spring elastic properties of ankyrin and cadherin repeats","volume":"13","author":"Sotomayor","year":"2005","journal-title":"Structure"},{"key":"R34-11-20210206","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/cne.20513","article-title":"Development and properties of stereociliary link types in hair cells of the mouse cochlea","volume":"485","author":"Goodyear","year":"2005","journal-title":"J Comp Neurol"},{"key":"R36-11-20210206","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/79171","article-title":"A defect in harmonin, a PDZ domain-containing protein expressed in the inner ear sensory hair cells, underlies Usher syndrome type 1C","volume":"26","author":"Verpy","year":"2000","journal-title":"Nat Genet"},{"key":"R37-11-20210206","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1093\/hmg\/ddg042","article-title":"Mutations in a new scaffold protein Sans cause deafness in Jackson shaker mice","volume":"12","author":"Kikkawa","year":"2003","journal-title":"Hum Mol Genet"},{"key":"R38-11-20210206","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1093\/hmg\/ddg051","article-title":"Usher syndrome type I G (USH1G) is caused by mutations in the gene encoding SANS, a protein that associates with the USH1C protein, harmonin","volume":"12","author":"Weil","year":"2003","journal-title":"Hum Mol Genet"},{"key":"R39-11-20210206","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/374060a0","article-title":"Defective myosin VIIA gene responsible for Usher syndrome type 1B","volume":"374","author":"Weil","year":"1995","journal-title":"Nature"},{"key":"R40-11-20210206","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/374062a0","article-title":"A type VII myosin encoded by the mouse deafness gene shaker-1","volume":"374","author":"Gibson","year":"1995","journal-title":"Nature"},{"key":"R41-11-20210206","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0378-1119(01)00761-2","article-title":"Genomic structure, alternative splice forms and normal and mutant alleles of cadherin 23 (Cdh23)","volume":"281","author":"Di Palma","year":"2001","journal-title":"Gene"},{"key":"R42-11-20210206","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/hmg\/ddi031","article-title":"Interactions in the network of Usher syndrome type 1 proteins","volume":"14","author":"Adato","year":"2005","journal-title":"Hum Mol Genet"},{"key":"R43-11-20210206","doi-asserted-by":"crossref","first-page":"14946","DOI":"10.1073\/pnas.232579599","article-title":"The Usher syndrome proteins cadherin 23 and harmonin form a complex by means of PDZ-domain interactions","volume":"99","author":"Siemens","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R44-11-20210206","doi-asserted-by":"crossref","first-page":"6689","DOI":"10.1093\/emboj\/cdf689","article-title":"Myosin VIIa, harmonin and cadherin 23, three Usher I gene products that cooperate to shape the sensory hair cell bundle","volume":"21","author":"Boeda","year":"2002","journal-title":"EMBO J"},{"key":"R45-11-20210206","doi-asserted-by":"crossref","first-page":"5575","DOI":"10.1073\/pnas.0901819106","article-title":"Assembling stable hair cell tip link complex via multidentate interactions between harmonin and cadherin 23","volume":"106","author":"Pan","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R46-11-20210206","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.heares.2005.05.008","article-title":"Sustained cadherin 23 expression in young and adult cochlea of normal and hearing-impaired mice","volume":"208","author":"Rzadzinska","year":"2005","journal-title":"Hear Res"},{"key":"R47-11-20210206","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1242\/dev.012922","article-title":"A core cochlear phenotype in USH1 mouse mutants implicates fibrous links of the hair bundle in its cohesion, orientation and differential growth","volume":"135","author":"Lefevre","year":"2008","journal-title":"Development"},{"key":"R48-11-20210206","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.neuron.2009.04.006","article-title":"Harmonin mutations cause mechanotransduction defects in cochlear hair cells","volume":"62","author":"Grillet","year":"2009","journal-title":"Neuron"},{"key":"R49-11-20210206","doi-asserted-by":"crossref","first-page":"9815","DOI":"10.1073\/pnas.92.21.9815","article-title":"Expression in cochlea and retina of myosin VIIa, the gene product defective in Usher syndrome type 1B","volume":"92","author":"Hasson","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R50-11-20210206","doi-asserted-by":"crossref","first-page":"8637","DOI":"10.1523\/JNEUROSCI.18-21-08637.1998","article-title":"Localization of myosin-Ibeta near both ends of tip links in frog saccular hair cells","volume":"18","author":"Garcia","year":"1998","journal-title":"J Neurosci"},{"key":"R51-11-20210206","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1523\/JNEUROSCI.4251-05.2006","article-title":"Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells","volume":"26","author":"Senften","year":"2006","journal-title":"J Neurosci"},{"key":"R52-11-20210206","doi-asserted-by":"crossref","first-page":"10777","DOI":"10.1523\/JNEUROSCI.1847-06.2006","article-title":"Stereociliary myosin-1c receptors are sensitive to calcium chelation and absent from cadherin 23 mutant mice","volume":"26","author":"Phillips","year":"2006","journal-title":"J Neurosci"},{"key":"R53-11-20210206","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1086\/341558","article-title":"CDH23 mutation and phenotype heterogeneity: a profile of 107 diverse families with Usher syndrome and nonsyndromic deafness","volume":"71","author":"Astuto","year":"2002","journal-title":"Am J Hum Genet"},{"key":"R54-11-20210206","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1097\/00129492-200409000-00009","article-title":"Variable clinical features in patients with CDH23 mutations (USH1D-DFNB12)","volume":"25","author":"Pennings","year":"2004","journal-title":"Otol Neurotol"},{"key":"R55-11-20210206","doi-asserted-by":"crossref","first-page":"5252","DOI":"10.1073\/pnas.0900691106","article-title":"A mouse model for nonsyndromic deafness (DFNB12) links hearing loss to defects in tip links of mechanosensory hair cells","volume":"106","author":"Schwander","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R56-11-20210206","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1146\/annurev.bioeng.8.061505.095753","article-title":"Mechanism and dynamics of cadherin adhesion","volume":"8","author":"Leckband","year":"2006","journal-title":"Annu Rev Biomed Eng"},{"key":"R57-11-20210206","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/ng1226","article-title":"Association of cadherin 23 with polygenic inheritance and genetic modification of sensorineural hearing loss","volume":"35","author":"Noben-Trauth","year":"2003","journal-title":"Nat Genet"},{"key":"R58-11-20210206","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/ajhb.20744","article-title":"Single nucleotide polymorphisms in the cadherin 23 (CDH23) gene in Polish workers exposed to industrial noise","volume":"20","author":"Sliwinska-Kowalska","year":"2008","journal-title":"Am J Hum Biol"},{"key":"R59-11-20210206","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1074\/jbc.M806177200","article-title":"Calcium-dependent binding of HCN1 channel protein to hair cell stereociliary tip link protein protocadherin 15 CD3","volume":"284","author":"Ramakrishnan","year":"2009","journal-title":"J Biol Chem"},{"key":"R60-11-20210206","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1113\/jphysiol.2008.163444","article-title":"In vitro characterization of HCN channel kinetics and frequency dependence in myocytes predicts biological pacemaker functionality","volume":"587","author":"Zhao","year":"2009","journal-title":"J Physiol"},{"key":"R61-11-20210206","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0006-3495(79)85267-4","article-title":"Response latency of vertebrate hair cells","volume":"26","author":"Corey","year":"1979","journal-title":"Biophys J"}],"container-title":["Current Opinion in Otolaryngology &amp; Head &amp; Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/MOO.0b013e3283303472","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T04:20:02Z","timestamp":1620966002000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00020840-200910000-00011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":60,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1097\/moo.0b013e3283303472","relation":{},"ISSN":["1068-9508"],"issn-type":[{"value":"1068-9508","type":"print"}],"subject":[],"published":{"date-parts":[[2009,10]]}}}