{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:22:04Z","timestamp":1786119724110,"version":"build-2736575974"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1097\/moo.0b013e3283450102","type":"journal-article","created":{"date-parts":[[2011,3,3]],"date-time":"2011-03-03T02:44:23Z","timestamp":1299120263000},"page":"210-217","source":"Crossref","is-referenced-by-count":29,"title":["Role of aspirin desensitization in the management of chronic rhinosinusitis"],"prefix":"10.1097","volume":"19","author":[{"given":"Habib","family":"Rizk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-15-20210206","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.iac.2009.07.009","article-title":"When surgery, antibiotics and steroids fail to resolve chronic rhinosinusitis","volume":"29","author":"Ferguson","year":"2009","journal-title":"Immunol Allergy Clin North Am"},{"key":"R2-15-20210206","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s11882-004-0037-x","article-title":"Adverse respiratory reactions to aspirin and nonsteroidal anti-inflammatory drugs","volume":"4","author":"Simon","year":"2004","journal-title":"Curr Allergy Asthma Rep"},{"key":"R3-15-20210206","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/01.all.0000225153.45027.6a","article-title":"Aspirin desensitization in aspirin intolerance: update on current standards and recent improvements","volume":"6","author":"Pfaar","year":"2006","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"R4-15-20210206","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1097\/MAJ.0b013e3181eecfc7","article-title":"Aspirin desensitization\/challenge in 3 patients with unstable angina","volume":"340","author":"Ortega-Loayza","year":"2010","journal-title":"Am J Med Sci"},{"key":"R5-15-20210206","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s11882-009-0023-4","article-title":"Aspirin sensitivity and desensitization for asthma and sinusitis","volume":"9","author":"Stevenson","year":"2009","journal-title":"Curr Allergy Asthma Rep"},{"key":"R7-15-20210206","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1067\/mai.2003.1487","article-title":"Aspirin-induced asthma: advances in pathogenesis, diagnosis and management","volume":"11","author":"Szczeklik","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"R8-15-20210206","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/00063198-200401000-00009","article-title":"Aspirin intolerance and the cyclooxygenase-leukotriene pathways","volume":"10","author":"Szczeklik","year":"2004","journal-title":"Curr Opin Pulm Med"},{"key":"R9-15-20210206","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1097\/01.moo.0000124938.46948.c7","article-title":"Categorization of eosinophilic chronic rhinosinusitis","volume":"12","author":"Ferguson","year":"2004","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"R10-15-20210206","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/00020840-200206000-00012","article-title":"The role of aspirin sensitivity and nasal polyposis","volume":"10","author":"Cook","year":"2002","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"R11-15-20210206","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/j.1445-5994.2004.00801.x","article-title":"Aspirin-sensitive asthma","volume":"35","author":"Morwood","year":"2005","journal-title":"Int Med J"},{"key":"R12-15-20210206","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.jaci.2005.10.037","article-title":"Aspirin-sensitive rhinosinusitis is associated with reduced E-prostanoid 2 receptor expression on nasal mucosal inflammatory cells","volume":"117","author":"Ying","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"R13-15-20210206","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1056\/NEJMoa013508","article-title":"Leukotriene-receptor expression on nasal mucosal inflammatory cells in aspirin-sensitive rhinosinusitis","volume":"347","author":"Sousa","year":"2002","journal-title":"N Engl J Med"},{"key":"R14-15-20210206","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.2217\/14622416.8.9.1143","article-title":"CysLTR1 promoter polymorphism and requirement for leukotriene receptor antagonist in aspirin-intolerant asthma patients","volume":"8","author":"Kim","year":"2007","journal-title":"Pharmacogenomics"},{"key":"R15-15-20210206","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1111\/j.1398-9995.2009.01989.x","article-title":"Combined effect of IL-10 and TGF-b1 promoter polymorphisms as a risk factor for aspirin-intolerant asthma and rhinosinusitis","volume":"64","author":"Kim","year":"2009","journal-title":"Allergy"},{"key":"R16-15-20210206","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.iac.2009.07.008","article-title":"Aspirin intolerance: does desensitization alter the course of the disease?","volume":"29","author":"Klimek","year":"2009","journal-title":"Immunol Allergy Clin North Am"},{"key":"R17-15-20210206","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/S1734-1140(10)70309-1","article-title":"Aspirin-induced asthma: a tribute to John Vane as a source of inspiration","volume":"62","author":"Szczeklik","year":"2010","journal-title":"Pharmacol Rep"},{"key":"R18-15-20210206","doi-asserted-by":"crossref","first-page":"744","DOI":"10.3349\/ymj.2009.50.6.744","article-title":"Update on recent advances in the management of aspirin exacerbated respiratory disease","volume":"50","author":"Palikhe","year":"2009","journal-title":"Yonsei Med J"},{"key":"R19-15-20210206","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.jaci.2007.03.020","article-title":"The relationship between historical aspirin-induced asthma and severity of asthma induced during oral aspirin challenges","volume":"120","author":"Williams","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"R20-15-20210206","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.jaci.2008.09.048","article-title":"Rational approach to aspirin dosing during oral challenges and desensitization of patients with aspirin-exacerbated respiratory disease","volume":"123","author":"Hope","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"R21-15-20210206","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/0091-6749(80)90143-8","article-title":"Aspirin-sensitive asthma: tolerance to aspirin after positive oral aspirin challenges","volume":"66","author":"Stevenson","year":"1980","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"R22-15-20210206","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0091-6749(90)90222-P","article-title":"Long term effects of aspirin desensitization treatment for aspirin-sensitive rhinosinusitis asthma","volume":"85","author":"Sweet","year":"1990","journal-title":"J Allergy Clin Immunol"},{"key":"R23-15-20210206","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.iac.2009.04.012","article-title":"Rapid desensitization for hypersensitivity reactions to medications","volume":"29","author":"Castells","year":"2009","journal-title":"Immunol Allergy Clin North Am"},{"key":"R24-15-20210206","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1385\/CRIAI:24:2:189","article-title":"Prevention and treatment of reactions to NSAIDs","volume":"24","author":"Simon","year":"2003","journal-title":"Clin Rev Allergy Immunol"},{"key":"R25-15-20210206","doi-asserted-by":"crossref","first-page":"573","DOI":"10.2500\/ajr.2006.20.2913","article-title":"Medical and surgical considerations in patients with Samter's triad","volume":"20","author":"McCains","year":"2006","journal-title":"Am J Rhinol"},{"key":"R26-15-20210206","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1067\/mai.2003.7","article-title":"Long term treatment with aspirin desensitization in asthmatic patients with aspirin exacerbated respiratory disease","volume":"111","author":"Berges-Simeno","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"R27-15-20210206","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1034\/j.1399-3003.2000.016003432.x","article-title":"Natural history of aspirin-induced asthma","volume":"16","author":"Szczeklik","year":"2000","journal-title":"Eur Respir J"},{"key":"R28-15-20210206","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jaci.2006.09.011","article-title":"Selection of aspirin dosages for aspirin desensitization treatment in patients with aspirin-exacerbated respiratory disease","volume":"119","author":"Lee","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"R29-15-20210206","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/S1081-1206(10)61803-0","article-title":"Early effects of aspirin desensitization treatment in asthmatic patients with aspirin-exacerbated respiratory disease","volume":"90","author":"Berges-Gimeno","year":"2003","journal-title":"Ann Allergy Asthma Immunol"},{"key":"R30-15-20210206","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.anai.2010.05.020","article-title":"Use of intranasal ketorolac and modified oral aspirin challenge for desensitization of aspirin-exacerbated respiratory disease","volume":"105","author":"Lee","year":"2010","journal-title":"Ann Allergy Asthma Immunol"},{"key":"R31-15-20210206","doi-asserted-by":"crossref","first-page":"175","DOI":"10.2500\/108854192778817202","article-title":"Management of aspirin-sensitive rhinosinusitis-asthma syndrome: what role for aspirin desensitization?","volume":"13","author":"Kowalski","year":"1992","journal-title":"Allergy Proc"},{"key":"R32-15-20210206","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.jaci.2006.06.019","article-title":"Selection of patients for aspirin desensitization treatment","volume":"118","author":"Stevenson","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"R33-15-20210206","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.jaci.2010.08.037","article-title":"Does suppression of Il-4 synthesis by aspirin explain the therapeutic benefit of aspirin desensitization treatment?","volume":"126","author":"White","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"R34-15-20210206","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1080\/00016480701724896","article-title":"Characteristics of recurrent chronic rhinosinusitis after previous surgical therapy","volume":"128","author":"Gosepath","year":"2008","journal-title":"Acta Otolaryngol"},{"key":"R35-15-20210206","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1001\/archotol.127.3.316","article-title":"Individual monitoring of aspirin desensitization","volume":"127","author":"Gosepath","year":"2001","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"R36-15-20210206","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.otc.2010.02.013","article-title":"Systemic therapies in managing sinonasal inflammation","volume":"43","author":"DeMarcantonio","year":"2010","journal-title":"Otolaryngol Clin North Am"},{"key":"R37-15-20210206","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1111\/j.1398-9995.2008.01658.x","article-title":"Long term treatment with aspirin desensitization: a prospective clinical trial comparing 100 and 300 mg aspirin daily","volume":"63","author":"Rozsasi","year":"2008","journal-title":"Allergy"},{"key":"R38-15-20210206","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1016\/0140-6736(91)93185-C","article-title":"Prevention of relapse in nasal polyposis","volume":"337","author":"Patriarca","year":"1991","journal-title":"Lancet"},{"key":"R39-15-20210206","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1097\/01.MLG.0000166702.38850.1B","article-title":"Intranasal lysine-aspirin in aspirin-sensitive nasal polyposis: a controlled trial","volume":"115","author":"Parikh","year":"2005","journal-title":"Laryngoscope"},{"issue":"Suppl 12","key":"R40-15-20210206","first-page":"5","article-title":"Eicosanoids, aspirin-intolerance and the upper airways: current standards and recent improvements of the desensitization therapy.","volume":"57","author":"Pfaar","year":"2006","journal-title":"J Phys Pharmacol"},{"key":"R41-15-20210206","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/00130832-200102000-00006","article-title":"Aspirin-induced rhinitis and asthma","volume":"1","author":"Szczeklik","year":"2001","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"R42-15-20210206","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.jaci.2009.07.031","article-title":"Modulation by aspirin of nuclear phospho-signal transducer and activator of transcription 6 expression: possible role in therapeutic benefit associated with aspirin desensitization","volume":"124","author":"Steinke","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"R43-15-20210206","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.jaci.2010.06.036","article-title":"The effect of aspirin desensitization on novel biomarkers in aspirin-exacerbated respiratory diseases","volume":"126","author":"Katial","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"R44-15-20210206","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s11882-008-0041-7","article-title":"The clinical effectiveness of aspirin desensitization in chronic rhinosinusitis","volume":"8","author":"Williams","year":"2008","journal-title":"Curr Allergy Asthma Rep"},{"key":"R45-15-20210206","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s11882-006-0032-5","article-title":"Does it make sense to \u2018desens\u2019? Aspirin desensitization in the treatment of chronic rhinosinusitis","volume":"6","author":"Lee","year":"2006","journal-title":"Curr Allergy Asthma Rep"}],"container-title":["Current Opinion in Otolaryngology & Head & Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/MOO.0b013e3283450102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:56:02Z","timestamp":1786042562000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00020840-201106000-00015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1097\/moo.0b013e3283450102","relation":{},"ISSN":["1068-9508"],"issn-type":[{"value":"1068-9508","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]}}}