{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:10:42Z","timestamp":1792656642479,"version":"4.5.0"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1097\/moo.0b013e32834a9852","type":"journal-article","created":{"date-parts":[[2011,8,6]],"date-time":"2011-08-06T05:32:43Z","timestamp":1312608763000},"page":"397-402","source":"Crossref","is-referenced-by-count":31,"title":["Genetic disorders of the vestibular system"],"prefix":"10.1097","volume":"19","author":[{"given":"Robert W.","family":"Eppsteiner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.H.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-15-20210206","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1532-5415.1989.tb05867.x","article-title":"Dizziness in a community elderly population.","volume":"37","author":"Sloane","year":"1989","journal-title":"J Am Geriatr Soc"},{"key":"R2-15-20210206","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1212\/01.wnl.0000175987.59991.3d","article-title":"Epidemiology of vestibular vertigo: a neurotologic survey of the general population.","volume":"65","author":"Neuhauser","year":"2005","journal-title":"Neurology"},{"key":"R3-15-20210206","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1001\/archinte.168.19.2118","article-title":"Burden of dizziness and vertigo in the community.","volume":"168","author":"Neuhauser","year":"2008","journal-title":"Arch Intern Med"},{"key":"R4-15-20210206","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1111\/j.1553-2712.2008.00189.x","article-title":"Dizziness presentations in U.S. emergency departments, 1995-2004.","volume":"15","author":"Kerber","year":"2008","journal-title":"Acad Emerg Med"},{"key":"R5-15-20210206","first-page":"197","article-title":"Vestibular function, falls and hip fracture in elderly: a relationship study in Hebrew.","volume":"143","author":"Zur","year":"2004","journal-title":"Harefuah"},{"key":"R6-15-20210206","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/WCO.0b013e3282f41ca0","article-title":"Recent advances in the genetics of recurrent vertigo and vestibulopathy.","volume":"21","author":"Jen","year":"2008","journal-title":"Curr Opin Neurol"},{"key":"R7-15-20210206","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1017\/S0022215100130567","article-title":"Anticipation in Menieres disease.","volume":"109","author":"Morrison","year":"1995","journal-title":"J Laryngol Otol"},{"key":"R8-15-20210206","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1001\/archotol.133.1.73","article-title":"Inheritance of Menieres disease in the Finnish population.","volume":"133","author":"Klockars","year":"2007","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"R9-15-20210206","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0030-6665(02)00018-X","article-title":"Genetics (molecular biology) and Menieres disease.","volume":"35","author":"Morrison","year":"2002","journal-title":"Otolaryngol Clin North Am"},{"key":"R10-15-20210206","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1177\/014556131008900309","article-title":"HLA-B27-associated bilateral Meniere disease.","volume":"89","author":"Rawal","year":"2010","journal-title":"Ear Nose Throat J"},{"key":"R11-15-20210206","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2310\/7070.2002.19261","article-title":"Genetic basis of familial Menieres disease.","volume":"31","author":"Fung","year":"2002","journal-title":"J Otolaryngol"},{"key":"R12-15-20210206","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-2350-12-2","article-title":"Polymorphisms of CD16A and CD32 Fcgamma receptors and circulating immune complexes in Menieres disease: a case-control study.","volume":"12","author":"Lopez-Escamez","year":"2011","journal-title":"BMC Med Genet"},{"key":"R13-15-20210206","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1159\/000322346","article-title":"Molecular analysis of aquaporin genes 1 to 4 in patients with Menieres disease.","volume":"26","author":"Candreia","year":"2010","journal-title":"Cell Physiol Biochem"},{"key":"R14-15-20210206","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1111\/j.1365-2826.2010.02060.x","article-title":"Expression and translocation of aquaporin-2 in the endolymphatic sac in patients with Menieres disease.","volume":"22","author":"Maekawa","year":"2010","journal-title":"J Neuroendocrinol"},{"key":"R15-15-20210206","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1159\/000089410","article-title":"Menieres disease is associated with single nucleotide polymorphisms in the human potassium channel genes, KCNE1 and KCNE3.","volume":"67","author":"Doi","year":"2005","journal-title":"ORL J Otorhinolaryngol Relat Spec"},{"key":"R16-15-20210206","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/ajmg.a.33114","article-title":"Polymorphisms in KCNE1 or KCNE3 are not associated with Meniere disease in the Caucasian population.","volume":"152A","author":"Campbell","year":"2010","journal-title":"Am J Med Genet A"},{"key":"R17-15-20210206","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1080\/00016480801901675","article-title":"Polymorphic analysis of the heat-shock protein 70 gene (HSPA1A) in Menieres disease.","volume":"128","author":"Kawaguchi","year":"2008","journal-title":"Acta Otolaryngol"},{"key":"R18-15-20210206","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1097\/MAO.0b013e318180a4b1","article-title":"Gly460Trp alpha-adducin mutation as a possible mechanism leading to endolymphatic hydrops in Menieres syndrome.","volume":"29","author":"Teggi","year":"2008","journal-title":"Otol Neurotol"},{"key":"R19-15-20210206","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/ajmg.b.30347","article-title":"A Menieres disease gene linked to chromosome 12p12.3.","volume":"141B","author":"Klar","year":"2006","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"R20-15-20210206","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/jhg.2010.122","article-title":"Familiar Menieres disease restricted to 1.48Mb on chromosome 12p12.3 by allelic and haplotype association.","volume":"55","author":"Gabrikova","year":"2010","journal-title":"J Hum Genet"},{"key":"R21-15-20210206","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1093\/hmg\/5.7.1047","article-title":"A gene for nonsyndromic autosomal dominant progressive postlingual sensorineural hearing loss maps to chromosome 14q12-13.","volume":"5","author":"Manolis","year":"1996","journal-title":"Hum Mol Genet"},{"key":"R22-15-20210206","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/sj.ejhg.5201043","article-title":"Mutations in the COCH gene are a frequent cause of autosomal dominant progressive cochleo-vestibular dysfunction, but not of Menieres disease.","volume":"11","author":"Usami","year":"2003","journal-title":"Eur J Hum Genet"},{"key":"R23-15-20210206","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/sj.ejhg.5201065","article-title":"Absence of COCH mutations in patients with Meniere disease.","volume":"12","author":"Sanchez","year":"2004","journal-title":"Eur J Hum Genet"},{"key":"R24-15-20210206","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1093\/hmg\/8.8.1425","article-title":"High prevalence of symptoms of Menieres disease in three families with a mutation in the COCH gene.","volume":"8","author":"Fransen","year":"1999","journal-title":"Hum Mol Genet"},{"key":"R25-15-20210206","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.otc.2010.05.010","article-title":"Genetic investigations of Menieres disease.","volume":"43","author":"Vrabec","year":"2010","journal-title":"Otolaryngol Clin North Am"},{"key":"R27-15-20210206","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/jhg.2010.29","article-title":"Genetics and pathological mechanisms of Usher syndrome.","volume":"55","author":"Yan","year":"2010","journal-title":"J Hum Genet"},{"key":"R28-15-20210206","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/ajmg.1320500107","article-title":"Clinical diagnosis of the Usher syndromes: Usher syndrome consortium.","volume":"50","author":"Smith","year":"1994","journal-title":"Am J Med Genet"},{"key":"R30-15-20210206","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1086\/302026","article-title":"Mutations in the myosin VIIA gene cause a wide phenotypic spectrum, including atypical Usher syndrome.","volume":"63","author":"Liu","year":"1998","journal-title":"Am J Hum Genet"},{"key":"R31-15-20210206","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1399-0004.2008.01038.x","article-title":"USH1H, a novel locus for type I Usher syndrome, maps to chromosome 15q22-23.","volume":"75","author":"Ahmed","year":"2009","journal-title":"Clin Genet"},{"key":"R32-15-20210206","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1086\/341558","article-title":"CDH23 mutation and phenotype heterogeneity: a profile of 107 diverse families with Usher syndrome and nonsyndromic deafness.","volume":"71","author":"Astuto","year":"2002","journal-title":"Am J Hum Genet"},{"key":"R33-15-20210206","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1080\/14992020500060610","article-title":"Audiological and vestibular features in affected subjects with USH3: a genotypephenotype correlation.","volume":"44","author":"Sadeghi","year":"2005","journal-title":"Int J Audiol"},{"key":"R34-15-20210206","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1016\/j.ophtha.2010.10.047","article-title":"CLRN1 mutations cause nonsyndromic retinitis pigmentosa.","volume":"118","author":"Khan","year":"2011","journal-title":"Ophthalmology"},{"key":"R35-15-20210206","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/ejhg.2010.140","article-title":"Alternative splice variants of the USH3A gene Clarin 1 (CLRN1).","volume":"19","author":"Vastinsalo","year":"2011","journal-title":"Eur J Hum Genet"},{"key":"R36-15-20210206","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1172\/JCI39715","article-title":"PDZD7 is a modifier of retinal disease and a contributor to digenic Usher syndrome.","volume":"120","author":"Ebermann","year":"2010","journal-title":"J Clin Invest"},{"key":"R37-15-20210206","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1002\/ajmg.a.33828","article-title":"Vestibular dysfunction in DFNB1 deafness.","volume":"155","author":"Dodson","year":"2011","journal-title":"Am J Med Genet A"},{"key":"R38-15-20210206","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1080\/00016480310002500","article-title":"Familial early-onset progressive vestibulopathy without hearing impairment.","volume":"123","author":"Brantberg","year":"2003","journal-title":"Acta Otolaryngol"}],"container-title":["Current Opinion in Otolaryngology & Head & Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/MOO.0b013e32834a9852","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T20:13:46Z","timestamp":1786047226000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00020840-201110000-00015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1097\/moo.0b013e32834a9852","relation":{},"ISSN":["1068-9508"],"issn-type":[{"value":"1068-9508","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]}}}